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Rapid global ocean-atmosphere response to Southern Ocean freshening during the last glacial

Contrasting Greenland and Antarctic temperatures during the last glacial period (115,000 to 11,650 years ago) are thought to have been driven by imbalances in the rates of formation of North Atlantic and Antarctic Deep Water (the 'bipolar seesaw'). Here we exploit a bidecadally resolved 14C data set obtained from New Zealand kauri (Agathis australis) to undertake high-precision alignment of key cl

Thermodynamic assessment and binary nucleation modeling of Sn-seeded InGaAs nanowires

We have performed a thermodynamic assessment of the As-Ga-In-Sn system based on the CALculation of PHAse Diagram (CALPHAD) method. This system is part of a comprehensive thermodynamic database that we are developing for nanowire materials. Specifically, the As-Ga-In-Sn can be used in modeling the growth of GaAs, InAs, and InxGa1−xAs nanowires assisted by Sn liquid seeds. In this work, the As-Sn bi

Extraction of soluble arabinoxylan from enzymatically pretreated wheat bran and production of short xylo-oligosaccharides and arabinoxylo-oligosaccharides from arabinoxylan by glycoside hydrolase family 10 and 11 endoxylanases

The enzymatic, ecofriendly pretreatment of wheat bran with α-amylase from Bacillus amyloliquifaciens or B. licheniformis at 90 °C for 1.5 h followed by Neutrase at 50 °C for 4 h, aqueous liquefaction at 121 °C for 15 h and ethanol precipitation enabled the production of soluble arabinoxylan (AX) with purity of 70.9% and 68.4% (w/w) respectively. Process alternatives tried, to simplify the process

Health Among Schoolchildren From the School Nurse’s Perspective

The aim of the study was to investigate Swedish school nurses’ perceptions of schoolchildren’s health. The study is based on two national surveys in which school nurses responded to questions about schoolchildren’s health in 2015 (n = 181) and 2005 (n = 129). A statistical comparison showed that physical and mental health of schoolchildren in high-risk areas was perceived as worse than that of chi

Distinct DC subsets regulate adaptive Th1 and 2 responses during Trichuris muris infection

Low- and high-dose infections with the murine large intestinal nematode Trichuris muris are associated with induction of adaptive Th1 and Th2 responses, respectively, in mesenteric lymph nodes (MLN). Classical dendritic cells (cDC) accumulate in the large intestinal mucosa and MLN upon T. muris infection, yet their role in driving adaptive responses to infection remains largely unknown. We perform

Palaeocene faulting in SE Sweden from U–Pb dating of slickenfibre calcite

Estimating the timing of faulting is crucial to modelling tectonics, palaeoseismicity, landscape evolution and fault mechanics. Four slickenfibre calcite samples from a conjugate strike-slip fault set in a platformal limestone, SE Sweden, were dated using U–Pb. Three of the samples yielded an average age of 64.8 ± 6.5 Ma, while the fourth yielded a marginally younger age of 54.7 ± 5.5 Ma. Precipit

Variation in Results Due to User Effects in a Simulation with FDS

The results from a round-robin study in which practicing fire safety engineers simulated the same scenario are presented in this paper. The simulation task included the simulation of an 800 mm heptane pool in a three-room apartment. The participants, representing eight Swedish consultancy firms, simulated the well-specified scenario with FDS 5. The participants received information about the build

Cu/Zn Superoxide Dismutase Forms Amyloid Fibrils under Near-Physiological Quiescent Conditions : The Roles of Disulfide Bonds and Effects of Denaturant

Cu/Zn superoxide dismutase (SOD1) forms intracellular aggregates that are pathological indicators of amyotrophic lateral sclerosis. A large body of research indicates that the entry point to aggregate formation is a monomeric, metal-ion free (apo), and disulfide-reduced species. Fibril formation by SOD1 in vitro has typically been reported only for harsh solvent conditions or mechanical agitation.

Process measures or patient reported experience measures (PREMs) for comparing performance across providers? : A study of measures related to access and continuity in Swedish primary care

Aim: To study (a) the covariation between patient reported experience measures (PREMs) and registered process measures of access and continuity when ranking providers in a primary care setting, and (b) whether registered process measures or PREMs provided more or less information about potential linkages between levels of access and continuity and explaining variables. Background: Access and conti

Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization

Retinoid X receptors (RXRs) play key roles in many physiological processes in both the periphery and central nervous system. In addition, RXRs form heterodimers with other nuclear receptors to exert their physiological effects. The nuclear receptor related 1 protein (NURR1) is particularly interesting because of its role in promoting differentiation and survival of dopamine neurons. However, only

On Reciprocal Causation in the Evolutionary Process

Recent calls for a revision of standard evolutionary theory (SET) are based partly on arguments about the reciprocal causation. Reciprocal causation means that cause–effect relationships are bi-directional, as a cause could later become an effect and vice versa. Such dynamic cause-effect relationships raise questions about the distinction between proximate and ultimate causes, as originally formul

On the Semiclassical Analysis of the Ground State Energy of the Dirichlet Pauli Operator in Non-Simply Connected Domains

We consider the Dirichlet Pauli operator in bounded connected domains in the plane, with a semiclassical parameter. We show that the ground state energy of the Pauli operator is exponentially small as the semiclassical parameter tends to zero and estimate the decay rate. This extends our recent results discussing a recent paper by Ekholm–Kovařík–Portmann, including non-simply connected domains.

Exploring sources of biogenic secondary organic aerosol compounds using chemical analysis and the FLEXPART model

Molecular tracers in secondary organic aerosols (SOAs) can provide information on origin of SOA, as well as regional scale processes involved in their formation. In this study 9 carboxylic acids, 11 organosulfates (OSs) and 2 nitrooxy organosulfates (NOSs) were determined in daily aerosol particle filter samples from Vavihill measurement station in southern Sweden during June and July 2012. Severa

Nyttoanalys av spisvakt och portabelt sprinklersystem vid bostadsbränder

A cost benefit analysis has been performed on the installation of stove guards or portable sprinkler systems as a means for reducing injuries in the case of a residential fire. The installations are analyzed separately and the benefit ratio is below 1.0 in most cases, indicating a low benefit in relation to the installation and maintenance costs. However, the benefit ratio is well above 1.0 for ce

Club cell protein (CC16) in plasma, bronchial brushes, BAL and urine following an inhaled allergen challenge in allergic asthmatics

Background: Club cell protein (CC16) is a pneumoprotein secreted by epithelial club cells. CC16 possesses anti-inflammatory properties and is a potential biomarker for airway epithelial damage. We studied the effect of inhaled allergen on pulmonary and systemic CC16 levels. Methods: Thirty-four subjects with allergic asthma underwent an inhaled allergen challenge. Bronchoscopy with bronchoalveolar

Age-Dependent Alpha-Synuclein Accumulation and Phosphorylation in the Enteric Nervous System in a Transgenic Mouse Model of Parkinson’s Disease

The enteric nervous system (ENS) controls the function of the gastrointestinal tract and has been implicated in various diseases, including Parkinson’s disease (PD). PD is a neurodegenerative disease with Lewy bodies (LBs) and Lewy neurites (LNs) as the main pathological features. In addition to the typical motor symptoms in PD, attention has been drawn to non-motor symptoms, such as constipation,

The Inherent Complexity of Agglomeration : Essays on the self-organization of urban economies

Den här avhandlingen kombinerar vetenskapen om komplexa adaptiva system med ekonomiska geografi för att beskriva och undersöka självorganiserande principer och drag i täta urbana ekonomier, särskilt med avseende på flöden av information och kunskap mellan människor som ger upphov till produktivitetsrelaterade externaliteter. Avhandlingen består av en kappa som presenterar det övergripande ramverkeThis doctoral thesis combines complexity science and economic geography in order to explore bottom-up, self-organizing principles within urban economies, in particular in relation to the flow of information and knowledge between people. The thesis consists of a kappa that covers the general theoretical framework and four papers. The papers cover urban scaling and intra-urban scaling analysis, loca

Legal Facts in Argumentation-Based Litigation Games

This paper analyzes legal fact-argumentation in the framework of the argumentation-based litigation game (ALG) by Xiong (Leg Sci 370(9):16–19, 2012). Rather than as an ontological one, an ALG treats a legal fact as a fact-qua-claim whose acceptability depends on the reasons supporting it. In constructing their facts-qua-claims, parties to an ALG must interact to maintain a game-theoretic equilibri

Modelling past, present and future peatland carbon accumulation across the pan-Arctic region

Most northern peatlands developed during the Holocene, sequestering large amounts of carbon in terrestrial ecosystems. However, recent syntheses have highlighted the gaps in our understanding of peatland carbon accumulation. Assessments of the long-Term carbon accumulation rate and possible warming-driven changes in these accumulation rates can therefore benefit from process-based modelling studie