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Iron enzymes play critical roles in biological oxidation reactions by utilizing highly reactive high-valent iron intermediates, such as FeIV=O, FeV(O)(OH), and FeIV=NR species, for catalytic reactions. These intermediates exhibit remarkable catalytic behavior with high reactivities and high regio- and stereospecificity in various biochemical reactions. Understanding these metal intermediates is cr
Acute and chronic lung diseases are a major cause of global mortality. While pharmacological approaches exist, no therapies are curative. The only option at end-stage disease is lung transplantation which is hampered by a chronic shortage of donor organs. Therefore, there is a high interest to develop alternative approaches to use regenerative medicine approaches to generate new lung tissue in the
BACKGROUND: Chronic low-grade inflammation may play a role in the pathophysiology of depression, at least in a subset of patients. High-sensitivity C-reactive protein (hs-CRP) has been used to define an inflamed subgroup of depression with specific clinical characteristics and symptoms. In this study we investigated biochemical and clinical characteristics in patients with difficult-to-treat depre
Objectives: Artificial intelligence (AI) is increasingly tested and integrated into breast cancer screening. Still, there are unresolved issues regarding its possible ethical, social and legal impacts. Furthermore, the perspectives of different actors are lacking. This study investigates the views of breast radiologists on AI-supported mammography screening, with a focus on attitudes, perceived be
BackgroundPathogenic germline variants (PGVs) in certain genes are linked to higher lifetime risk of developing breast cancer and can influence preventive surgery decisions and therapy choices. Public health programs offer genetic screening based on criteria designed to assess personal risk and identify individuals more likely to carry PGVs, dividing patients into screened and non-screened groups.
Lung cancer is primarily a disease of the elderly, with a median age at diagnosis around 70 years. In our study we sought to address the question of whether and how clinical characteristics, molecular alterations and molecular phenotypes differ between patient populations with early-stage lung adenocarcinoma (AC) with respect to age at diagnosis. Patients were stratified based on age at diagnosis
The quantum many-body interactions in one-dimensional spin- 1/2 systems are subject to Tomonaga-Luttinger liquid (TLL) physics, which predict an array of multiparticle excitations that form continua in momentum-energy space. Here we use inelastic neutron spectroscopy to study the TLL spin dynamics in SrCo2V2O8 , a compound which contains weakly coupled spin-1/2 chains of Co atoms, at 0.05 K and in
Objective: The purpose of this paper is to identify the largest cognitive challenges faced by novices, developing software in teams, using distributed cognition as an observational filter.Paradigm: Design science Epistemology: Pragmatist Methodology: Case studyMethod: Using grounded theory, ethnography and multi method data collection, we conducted an observational study for two months following f
The chapter maps out the elite of the early Danish temperance movement and shows how distinct moral elites within the movement interpreted the cause according to their respective value frames while integrating the emerging disease frame of alcoholism. Theoretically, it argues for introducing the thus far estranged perspectives of elite studies and framing approaches to each other. The concept of m
This contribution aims to elucidate some problematic aspects of the financial tools (such as the Conditionality Regulation, Recovery and Resilience Facility and other measures), used by the EU to ensure compliance with the rule of law. It draws attention to certain legal conundrums which challenge the functional effectiveness of these tools both within the Union (the internal dimension) and in the
The maintenance of protein homeostasis, also referred to as proteostasis, is essential for preserving the structural and functional stability of the proteome in living organisms. This involves the precise control of protein synthesis, folding, and degradation. As proteostasis disruption can cause growth and survival deficiencies in bacteria, the investigation of proteostasis has rapidly emerged as
The brain is the key organ that orchestrates the stress response which translates to the retina. The retina is an extension of the brain and retinal symptoms in subjects with neurodegenerative diseases substantiated the eye as a window to the brain. The retina is used in this study to determine whether chronic stress reflects neurodegenerative signs indicative of neurodegenerative conditions. A 3-
Denna rapport är en sammanställning och analys av kunskapsläget när det gäller ekosystembaserade metoder för att minska utsläpp och öka upptag av koldioxid hos brukade marker i Skåne. Med fokus på markanvändning och skötselstrategier inom jordbruk och skogsbruk, samt användning av biokol, analyseras och bedöms potentialen för att inom Skånes gränser öka upptag respektive minska utsläpp av kol från
