Objective: To report the efficacy of different anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs) on headache frequency, intensity, and duration. Background: Blockade of CGRP receptors or neuropeptide with anti-CGRP mAbs have been successfully used for several years for the prevention of chronic and episodic migraine. The response is usually assessed by improvement seen in th

Context.Gaia Data Release 3 (DR3) contains the first release of magnitudes estimated from the integration of Radial Velocity Spectrometer (RVS) spectra for a sample of about 32.2 million stars brighter than GRVS∼ 14 mag (or G ∼ 15 mag). Aims. In this paper, we describe the data used and the approach adopted to derive and validate the GRVS magnitudes published in DR3. We also provide estimates of t

IASPIS är Konstnärsnämndens internationella program inom bild- och formområdet. Det riktar sig till dig som är yrkesverksam konstnär inom bild- och formområdet och har en konstnärlig praktik inom exempelvis bildkonst, fotografi, formgivning, konsthantverk, design, illustration, textilkonst eller arkitektur.

Halide perovskites solar cells are now approaching commercialisation. In this transition from academic research towards industrialisation, standardized testing protocols and reliable dissemination of performance metrics are crucial. In this study, we analyze data from over 16,000 publications in the Perovskite Database to investigate the assumed equality between the integrated external quantum eff

A stressor-related disorder wherein traumatic experience precipitates protracted disruptions to mood and cognition, post-traumatic stress disorder (PTSD) is associated with wide-ranging abnormalities across the body. While various methods have investigated these deviations, only proton magnetic resonance spectroscopy (1H MRS) enables noninvasive measurement of small-molecule metabolites in the liv

Food, hygiene, and safety are critical in healthcare institutions, especially those in which patients are vulnerable against diseases triggered by food prepared under improper conditions. In the United Kingdom, almost 400 healthcare institutions were found to need significant improvements to their food preparation standards (ITV News, 2016). Such institutions still rely on traditional pen and pape

Alzheimer’s disease (AD) is the leading cause of dementia and most common neurodegenerative disease worldwide, but there currently exists no effective treatment that can stop nor slow the progression of the disease. The current dogma in the field postulates that the appearance of extracellular amyloid-beta (Aβ) plaques, a histopathological hallmark of the disease, is the trigger for downstream, de

Seaweed is depicted as a future food in Western cultures, yet its introduction and expansion to new markets come with several challenges, including food neophobia and limited knowledge about its usability. To address these challenges, this study characterizes sensory perceptions, nutritional content, and physicochemical properties of four common northern European seaweed species, Saccharina latiss

The regional development studies community increasingly focuses on the significance of agency when investigating why some regions or cities develop better or worse than others. Undoubtedly, this line of research increases our understanding of the relations and interplay between human actions and socially produced structures. The articles in this special issue follow this research agenda by focusin

Background Neighborhood deprivation has been found associated with both type 2 diabetes and lung cancer. The aim of this study was to examine the potential association between neighborhood deprivation and lung cancer incidence or mortality in individuals diagnosed with type 2 diabetes. The results may identify a new risk or prognostic factor for lung cancer in this important subgroup and help deve

In Parkinson’s disease, there is an accumulation of α-synuclein (SYN) aggregates in neurons, which is promoted by neuroinflammation. In neural cells, cytokine-induced SYN aggregation is modulated by heparan sulfate (HS) derived from glypican-1 (GPC1) by amyloid precursor protein (APP) and nitric oxide (NO)-dependent cleavage. We have explored possible interplay between APP, GPC1, and SYN in undiff

Given a disproportionate scholarly focus on a high-profile litigation on manual scavenging–the manual cleaning of human faeces–in India, this paper aims to explore the experiences of NGOs led by Dalits–formerly “untouchables”–in navigating the judiciary to eradicate manual scavenging. It does so by first exploring the frequency and characteristics of court cases on manual scavenging, and second by

Reactive oxygen species (ROS) are implicated in epithelial cell-state transition and deposition of extracellular matrix upon airway injury. Of the many cellular targets of ROS, oxidative DNA modification is a major driving signal. However, the role of oxidative DNA damage in modulation profibrotic processes has not been fully delineated. Herein, we report that oxidative DNA base lesions, 8-oxoG, c

Rapid changes in forces and the resulting changes in acceleration, jerk and higher order derivatives can have undesired consequences beyond the effect of the forces themselves. Jerk can cause injuries in humans and racing animals and induce fatigue cracks in metals and other materials, which may ultimately lead to structure failures. This is a reason that it is used within standards for limits sta

OBJECTIVE: To investigate gastrointestinal infection episodes (GIEs) in relation to the appearance of islet autoantibodies in The Environmental Determinants of Diabetes in the Young (TEDDY) cohort.RESEARCH DESIGN AND METHODS: GIEs on risk of autoantibodies against either insulin (IAA) or GAD (GADA) as the first-appearing autoantibody were assessed in a 10-year follow-up of 7,867 children. Stool vi

The biotechnology industry has recently been demanding second generation of nanoparticle byproducts such as viruses, plasmids, virus-like particles and drug-delivery assemblies (20-300 nm). The possibility of preparing uniform nanoparticles consisting of proteins such as gelatin followed by covalent linkage of avidin was investigated. Gelatin nanoparticles were prepared by two-step desolvation. As

This article purports to explain why the concept of global civil society recently has attracted so much interest within academic and political discourse. Given the ambiguity and apparent incoherence of this concept, its centrality within contemporary International Relations and political theory is puzzling. The article argues that once we pay attention to the function of the concept of domestic ci