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The human population is still facing appalling conditions due to several outbreaks of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) virus. The absence of specific drugs, appropriate vaccines for mutants, and knowledge of potential therapeutic agents makes this situation more difficult. Several 1, 2, 4-triazolo [1, 5-a] pyrimidine (TP)-derivative compounds were comprehensively studie

Explosive volcanic eruptions can reach the stratosphere and cause elevated concentrations of sulphate particles for months to years. When these particles descend into the troposphere, they can impact cirrus clouds though to what degree is unknown. In this study, we combine three satellite data sets to investigate the impact of downwelling sulphate aerosol on midlatitude cirrus clouds during spring

The Wiedemann–Franz law states that the charge conductance and the electronic contribution to the heat conductance are proportional. This sets stringent constraints on efficiency bounds for thermoelectric applications, which seek a large charge conduction in response to a small heat flow. We present experiments based on a quantum dot formed inside a semiconducting InAs nanowire transistor, in whic

We report the strain and stress relationships for the three lowest energy direct band to band transitions at the Brillouin zone center in monoclinic β-Ga2O3. These relationships augment four linear perturbation parameters for situations, which maintain the monoclinic symmetry, which are reported here as numerical values obtained from density functional theory calculations. With knowledge of these

The 30+ unique ligands of the TGFβ family signal by forming complexes using different combinations of type I and type II receptors. Therapeutically, the extracellular domain of a single receptor fused to an Fc molecule can effectively neutralize subsets of ligands. Increased ligand specificity can be accomplished by using the extracellular domains of both the type I and type II receptor to mimic t

Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal disease. The only option for curative treatment is resection of the tumor followed by standard adjuvant chemotherapy. Yet, early relapse due to chemoresistance is almost inevitable. Herein, we delineated the genetic intratumor heterogeneity in resected PDAC, with the aim to identify evolutionary patterns that may be associated with ov

BackgroundSince the mid 80’ies, the western palliative care philosophy has influenced the development of palliative care in mainland China. However, it has caused several challenges.ObjectiveTo explore the understanding of the ‘good death’ among authorities, professionals, patients, and their relatives in end-of-life care settings in mainland China.DesignScoping review. The PRISMA-ScR checklist wa

I artikeln studeras spelutvecklares upplevelser av sitt arbete och då särskilt i relation till föreställningar om kreativa och ekonomiska ideal. Artikeln är baserad på en analys av semistrukturerade intervjuer med spelutvecklare i svenska dataspelsbolag. Genom begreppet ’relational work’ belyses spänningen mellan passion för arbetet och dess ekonomiska villkor, och hur gränserna mellan vad som ans

Rewetting dry soil induces enormous changes in microbial growth and biogeochemistry. Upon drying-rewetting (D/RW), bacteria have been shown to exhibit two different responses: (1) a more resilient response where bacteria start growing immediately with a quick recovery after rewetting and (2) a less resilient response where there is a pronounced lag-period before bacterial growth starts to increase

A series of iron(ii) complexes with the general formula [FeII(L2-Qn)(L)]n+ (n = 1, L = F−, Cl−; n = 2, L = NCMe, H2O) have been isolated and characterized. The X-ray crystallographic data reveals that metal–ligand bond distances vary with varying ligand field strengths of the sixth ligand. While the complexes with fluoride, chloride and water as axial ligand are high spin, the acetonitrile-coordin

The bending energy of the lipid membrane is central to biological processes involving vesicles, such as endocytosis and exocytosis. To illustrate the role of bending energy in these processes, we study the response of single-component giant unilamellar vesicles (GUVs) subjected to external osmotic stress by glucose addition. For osmotic pressures exceeding 0.15 atm, an abrupt shape change from sph

Many human birth defects and neurodevelopmental disorders are caused by loss-of-function mutations in a single copy of transcription factor (TF) and chromatin regulator genes. Although this dosage sensitivity has long been known, how and why haploinsufficiency (HI) of transcriptional regulators leads to developmental disorders (DDs) is unclear. Here I propose the hypothesis that such DDs result fr

A system we denote Seg2Pose is presented which converts pixel coordinate tracks, represented by instance segmentation masks across multiple video frames, into world coordinate pose tracks, for road users seen by static surveillance cameras. The road users are bound to a ground surface represented by a number of 3D points and does not necessarily have to be perfectly flat. The system works with one