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Solution Structure of the dATP-Inactivated Class I Ribonucleotide Reductase From Leeuwenhoekiella blandensis by SAXS and Cryo-Electron Microscopy

The essential enzyme ribonucleotide reductase (RNR) is highly regulated both at the level of overall activity and substrate specificity. Studies of class I, aerobic RNRs have shown that overall activity is downregulated by the binding of dATP to a small domain known as the ATP-cone often found at the N-terminus of RNR subunits, causing oligomerization that prevents formation of a necessary α2β2 co

The Accumulating Costs Hypothesis—to Better Understand Delayed “Hidden” Costs of Seemingly Mild Disease and Other Moderate Stressors

Mild diseases and moderate stressors are seemingly harmless and are therefore often assumed to have negligible impact on Darwinian fitness. Here we argue that the effects of “benign” parasites and other moderate stressors may have a greater impact on lifespan and other fitness traits than generally thought. We outline the “accumulating costs” hypothesis which proposes that moderate strains on the

Measurements of the inclusive and differential production cross sections of a top-quark–antiquark pair in association with a Z boson at √s=13 TeV with the ATLAS detector

Measurements of both the inclusive and differential production cross sections of a top-quark–antiquark pair in association with a Z boson (tt¯ Z) are presented. The measurements are performed by targeting final states with three or four isolated leptons (electrons or muons) and are based on s=13 TeV proton–proton collision data with an integrated luminosity of 139 fb - 1, recorded from 2015 to 201

Mortality after surgery for primary hyperparathyroidism : results from a nationwide cohort

BACKGROUND: Contemporary patients with primary hyperparathyroidism are often diagnosed with mildly raised serum calcium levels. Previous studies have reported increased mortality in patients with primary hyperparathyroidism. This retrospective cohort study aimed to examine whether contemporary patients operated for primary hyperparathyroidism have higher mortality than the general population, and

Patterns and resectability of colorectal cancer recurrences : outcome study within the COLOFOL trial

BACKGROUND: Improvements in surgery, imaging, adjuvant treatment, and management of metastatic disease have led to modification of previous approaches regarding the risk of recurrence and prognosis in colorectal cancer. The aims of this study were to map patterns, risk factors, and the possibility of curative treatment of recurrent colorectal cancer in a multimodal setting. METHODS: This was a coh

Energy dependence of ϕ meson production at forward rapidity in pp collisions at the LHC

The production of ϕ mesons has been studied in pp collisions at LHC energies with the ALICE detector via the dimuon decay channel in the rapidity region 2.5 < y< 4. Measurements of the differential cross section d 2σ/ d yd pT are presented as a function of the transverse momentum (pT) at the center-of-mass energies s=5.02, 8 and 13 TeV and compared with the ALICE results at midrapidity. The differ

Determination of the parton distribution functions of the proton from ATLAS measurements of differential W± and Z boson production in association with jets

This article presents a new set of proton parton distribution functions, ATLASepWZVjet20, produced in an analysis at next-to-next-to-leading order in QCD. The new data sets considered are the measurements of W+ and W− boson and Z boson production in association with jets in pp collisions at s = 8 TeV performed by the ATLAS experiment at the LHC with integrated luminosities of 20.2 fb−1 and 19.9 fb

Crystallization of a Zr-based metallic glass produced by laser powder bed fusion and suction casting

The crystallization behaviour during low temperature annealing of samples of the Zr59.3Cu28.8Al10.4Nb1.5 (at%) bulk metallic glass produced by suction casting and the laser powder bed fusion (LPBF) process were studied with small angle neutron scattering (SANS), X-ray diffraction and scanning electron microscopy. The in-situ SANS measurements during isothermal annealing reveals that the phase sepa

Spatial analysis of domestic water use and rural livelihoods in a semi-arid African highland

Rural communities throughout sub-Sahara Africa are hampered by unequal access to water resources, economic markets, and transportation. Further, development programs do not always provide uniform access to water supply, especially in water scarce regions. With a growing concern over the limited supply of ecosystem services, the need to understand how the complex realities of water use is affected

Biodiversity decline with increasing crop productivity in agricultural fields revealed by satellite remote sensing

Increasing land-use intensity is a main driver of biodiversity loss in farmland, but measuring proxies for land-use intensity across entire landscapes is challenging. Here, we develop a novel method for the assessment of the impact of land-use intensity on biodiversity in agricultural landscapes using remote sensing parameters derived from the Sentinel-2 satellites. We link crop phenology and prod

Sodium hydrosulfide has no additive effects on nitrite-inhibited renal gluconeogenesis in type 2 diabetic rats

Objective: Increased renal and hepatic gluconeogenesis are important sources of fasting hyperglycemia in type 2 diabetes (T2D). The inhibitory effect of co-administration of sodium nitrite and sodium hydrosulfide (NaSH) on hepatic but not renal gluconeogenesis has been reported in rats with T2D. The present study aimed to determine the effects of co-administration of sodium nitrite and NaSH on the

Food intake in children and adolescents : a cross-sectional study from 2009/2010 to 2015/2016

The aim was to describe food intake over time in children and adolescents, with respect to age and gender. The present study was a repeated cross-sectional study using self-reported data from a health questionnaire. Data were collected from the School Health Services in south-east Sweden from 44 297 students, 10, 13-14 and 16 years of age, 48 % girls and 52 % boys from 2009/2010 to 2015/2016. Repo

Test of the universality of τ and μ lepton couplings in W-boson decays with the ATLAS detector

The standard model of particle physics encapsulates our best current understanding of physics at the smallest scales. A fundamental axiom of this theory is the universality of the couplings of the different generations of leptons to the electroweak gauge bosons. The measurement of the ratio of the decay rate of W bosons to τ leptons and muons, R(τ/μ), constitutes an important test of this axiom. U

Russian government quality award : 25 years towards organizational excellence

Purpose: The purpose of this paper is to review the Russian Federation Government Quality Award (RFGQA) over its 25-year existence. Design/methodology/approach: This paper looks into the evolution, model and key provisions of RFGQA, based on the authors’ long-time experience as an Award assessor. Apart from that, methodologically, this study uses the desktop research method, comparative literature

Narrative Aspects of Images of Spear Use in Scandinavian Rock Carvings

Researchers have long discussed whether Scandinavian rock art reflects narratives. Their interpretations have frequently been based on inspections of rock art panels combined with knowledge from ethnographic and historical sources. Here, the authors adopt a more focused narratological approach that takes the concept of (visual) narrativity into consideration and draws on studies by literary analys