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Hunting for Protein Markers of Hypoxia by Combining Plasma Membrane Enrichment with a New Approach to Membrane Protein Analysis

Nontransient hypoxia is strongly associated with malignant lesions, resulting in aggressive behavior and resistance to treatment. We present an analysis of mRNA and protein expression changes in neuroblastoma cell lines occurring upon the transition from normoxia to hypoxia. The correlation between mRNA and protein level changes was poor, although some known hypoxia-driven genes and proteins corre

Pregabalin rectifies aberrant brain chemistry, connectivity, and functional response in chronic pain patients.

Chronic pain remains a significant challenge for modern health care as its pathologic mechanisms are largely unknown and preclinical animal models suffer from limitations in assessing this complex subjective experience. However, human brain neuroimaging techniques enable the assessment of functional and neurochemical alterations in patients experiencing chronic pain and how these factors may dynam

Meson-meson scattering in QCD-like theories

We discuss meson-meson scattering at next-to-next-to-leading order in the chiral expansion for QCD-like theories with general n degenerate flavours for the cases with a complex, real and pseudo-real representation. i.e. with global symmetry and breaking pattern SU(n)(L) x SU(n)(R) -> SU(n)(V), SU(2n) -> SO(2n) and SU(2n) -> Sp(2n). We obtain fully analytical expressions for all these cases. We dis

Mesozoic rift magmatism in the North Sea region: Ar-40/Ar-39 geochronology of Scanian basalts and geochemical constraints

More than 100 volcanic necks composed of basanites and melanephelinites occur in Scania, southern Sweden, at the junction of two major tectonic lineaments, the Phanerozoic Sorgenfrei-Tornquist Zone (STZ) and the Proterozoic Protogine Zone. New Ar-40/Ar-39 isotope analyses of whole rock fragments of nine selected basalt necks suggest that the Mesozoic alkaline volcanism in the Scanian province comm

Women's perceived frequency of disturbing interruptions and its relationship to self-rated health and satisfaction with life as whole

Daily occupations form a pattern dominated by a few main occupations intertwined with hidden occupations. A third category is denoted unexpected occupations or minor events that interrupt the rhythm of main and hidden occupations. The phenomenon of unexpected occupations can be interpreted as an illustration of interruptions in daily life or daily minor stressors. The study aimed to investigate wo

Biomarkers of rapid chronic kidney disease progression in type 2 diabetes.

Here we evaluated the performance of a large set of serum biomarkers for the prediction of rapid progression of chronic kidney disease (CKD) in patients with type 2 diabetes. We used a case-control design nested within a prospective cohort of patients with baseline eGFR 30-60 ml/min per 1.73 m(2). Within a 3.5-year period of Go-DARTS study patients, 154 had over a 40% eGFR decline and 153 controls

Computational investigation of dimple effects on heat transfer and friction factor in a Lamilloy cooling structure

Good heat transfer performance with a moderate pressure drop penalty contributes to the gas turbine engine lifetime and guaranteeing engine efficiency. In this study, the dimple effects for a Lamilloy (R) (Allison Advanced Development Corporation, Indiana, IN, USA) cooling structure on the heat transfer and friction factor are numerically investigated. The dimple is positioned directly under the j

Trust, welfare states and income equality: Sorting out the causality

The cross-country correlation between social trust and income equality is well documented, but few studies examine the direction of causality. We show theoretically that by facilitating cooperation, trust may lead to more equal outcomes, while the feedback from inequality to trust is ambiguous. Using a structural equation model estimated on a large country sample, we find that trust has a positive

Blood pressure levels and risk of cardiovascular events and mortality in type-2 diabetes: cohort study of 34 009 primary care patients.

OBJECTIVE:: The optimal blood pressure (BP) in persons with type-2 diabetes is debated. We investigated shapes of the associations of SBP and DBP levels with risk of cardiovascular events and mortality in a large primary care-based sample of diabetic patients. METHODS:: We investigated all 34 009 consecutive cardiovascular disease-free type-2 diabetes patients aged 35 years or older (mean age 64 y

Glutamine Synthetase Stability and Subcellular Distribution in Astrocytes are Regulated by G-Aminobutyric Type B Receptors.

Emerging evidence suggests that functional γ-aminobutyric acid B receptors (GABABRs) are expressed by astrocytes within the mammalian brain. GABABRs are heterodimeric G-protein coupled receptors that are composed of R1/R2 subunits. To date, they have been characterized in neurons as the principal mediators of sustained inhibitory signaling, however their roles in astrocytic physiology have been il

Symptomatic Mesenteric Atherosclerotic Disease-Lessons Learned from the Diagnostic Workup.

OBJECTIVE: This study aims to analyze the diagnostic workup in patients referred for endovascular mesenteric revascularization for symptomatic mesenteric atherosclerotic disease. MATERIAL AND METHODS: Fifty-five patients were identified between 2006 and 2011. Median follow-up time was 24 months. RESULTS: Median age was 71 years, 67 % were women. Forty patients had acute on chronic mesenteric ische

'The web is not enough, it's a base' - an explorative study of what needs a web-based support system for young carers must meet

The aim of this study was to gain knowledge about the specific needs that a web-based support system for young carers (YCs) must meet. Twelve young people with experience of caring for and supporting a close friend, partner or relative with mental illness (MI) were interviewed about their life situation, support needs and opinions about a hypothetical web-based support system. The transcribed inte

Macromolecular changes and nano-structural arrangements in gliadin and glutenin films upon chemical modification: Relation to functionality.

Protein macromolecules adopted for biological and bio-based material functions are known to develop a structured protein network upon chemical modification. In this study, we aimed to evaluate the impact of chemical additives such as, NaOH, NH4OH and salicylic acid (SA), on the secondary and nano-structural transitions of wheat proteins. Further, the effect of chemically induced modifications in p

Hom-Algebras And Hom-Coalgebras

The aim of this paper is to develop the theory of Hom-coalgebras and related structures. After reviewing some key constructions and examples of quasi-deformations of Lie algebras involving twisted derivations and giving rise to the class of quasi-Lie algebras incorporating Hom-Lie algebras, we describe the notion and some properties of Hom-algebras and provide examples. We introduce Hom-coalgebra