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A wide divergence has been detected in the telomeric sequences among budding yeast species. Despite their length and homogeneity differences, all these yeast telomeric sequences show a conserved core which closely matches the consensus RAP1-binding sequence. We demonstrate that the RAP1 protein binds this sequence core, without involving the diverged sequences outside the core. in Saccharomyces ca
OBJECTIVE: to explore Sudanese midwives' motives for and perceptions and experiences of re-infibulation after birth and to elucidate its context and determinants. DESIGN: triangulation of methods, using observational techniques and open-ended interviews. SETTING AND PARTICIPANTS: two government hospitals in Khartoum/Omdurman, Sudan, for the observations and in-depth interviews with 17 midwives. FI
Purpose. This article describes an ex vivo method to recondition and transplant rejected donor lungs. Description. A 19-year-old man was brain dead after a traffic accident. A roentgenogram showed bilateral lung contusion. He had ongoing intratracheal bleeding. After optimizing ventilator treatment and suctioning the airways, PaO2 was 9 kPa (67.5 mm Hg) on FiO(2) = 0.7. The lungs were rejected by
In an acute liver injury model we compared the effects of different Lactobacillus and Bifidobacterium strains on bacterial translocation, intestinal load of Enterobacteriaceae and the extent of liver injury. This was an experimental study carried out in an university hospital in Sweden. Sprague-Dawley rats were divided into six groups: liver injury control and five groups of liver injury with admi
Clavulanic acid is a beta-lactamase inhibitor used in therapeutic combinations with the penicillin-type antibiotics. During the fermentation leading to clavulanic acid, a succinyl L-tyrosine by-product is unavoidably formed. Occasionally, the amount of this by-product is found to be as high as 2% of the product even after standard purification operations. To further remove this impurity, we prepar
BACKGROUND: In the last 15 y there has been a tremendous increase in the number of studies on pediatric obesity looking at epidemiology, health-related risks, etiology, methodology and treatment. During the early 1990s, the European Childhood Obesity Group (ECOG) was born as a group of scientists' expert in the field of pediatric obesity. ECOG this year celebrates the approach to early maturity wi
Resistivity imaging in combination with borehole information is a powerful tool for site investigation. We show that the combination of 1D laterally constrained inversion (1D-LCI) with the use of a priori information from borehole data and 2D smooth inversion adds significant value to the interpretation of continuous vertical electrical sounding (CVES) data. The ID-LCI offers an analysis of the re
Having shown how Construction NOM and Construction PROP differ, I demonstrate that the subject of Construction PROP is clausal. I argue that the topmost XP of the subject phrase of both constructions contains a null neuter element. This accounts for the neuter predicative agreement; hence the idea of default agreement or semantic agreement can be dismissed. I also argue that the subject in (ii) co
The two-photon spectrum of the 2(1)A(g)-->1(1)A(g) transition in trans-stilbene has been calculated at the complete active space self-consistent field (CASSCF) level of theory. Energies were obtained at the complete active space second-order perturbation (CASPT2) level of theory, while the geometries of both the initial and final states were optimized at the CASSCF level. The energy and the geomet
Mantle cell lymphoma (MCL) is considered incurable. Intensive immunochemotherapy with stem cell support has not been tested in large, prospective series. In the 2nd Nordic MCL trial, we treated 160 consecutive, untreated patients younger than 66 years in a phase 2 protocol with dose-intensified induction immunochemotherapy with rituximab (R) + cyclophosphamide, vincristine, doxorubicin, prednisone
Some of Maurice Jacob's contributions to the European physics community are described, by giving examples of his great achievements. I have come to the conclusion that his success depended on his far-reaching vision, his ability to define the goals and to find realistic solutions for realizing them. He was a trustworthy partner in negotiations due to his outstanding breath of knowledge, his high s
Observations based on overexpression of the suppressor gene p53 or interference with endogenous p53 support a role for p53 in mediating not only growth inhibition and apoptosis but also differentiation. The aim of this study was to characterize the mechanisms of p53-dependent differentiation in the monoblastic leukemia cell line U-937. These cells were transfected with a mutant of the p53 gene exp
The present paper argues that there is both a positive and a negative form of perfectionism, and that they can be differentiated in terms of acceptance. The basic argument is that there is nothing unhealthy or dysfunctional about the striving for perfection as such—perfectionism, however, becomes dysfunctional when this striving for perfection turns into a demand for perfection, defined as an inab
Orexins are neuropeptides selectively expressed in a small number of neurons in the lateral–posterior hypothalamus. We measured orexin-A in the cerebrospinal fluid (CSF) of 66 patients with major depressive disorder (MDD), dysthymia and adjustment disorder after a suicide attempt. Blood samples confirmed that the patients were free from antidepressive and neuroleptic medication at the time of the
A new heterosporous fern species, Azolla boliviensis sp. nov., is described from latest Maastrichtian (latest Cretaceous) to Paleocene (earliest Palaeogene) terrestrial sediments of the Eslabon and Flora Formations. Subandean belt, Bolivia. The species is represented by dissociated but abundantly co-preserved megasporocarps, megaspores, microsporangia, massulae and microspores. The genus consisten
