Objective In numerous studies aspiring to clarify when to discontinue direct oral anticoagulants (DOAC) before central nerve blocks (CNB), information about the technique: spinal, epidural, indwelling catheter, multiple attempts, ‘bloody tap’: is incomplete. This creates difficulty making evidence-based recommendations regarding the safest time frame between the last dose of DOAC and CNB to avoid

Leadership is complex, and leadership in a global business is no less complex. To a great extent, the challenge in leadership is to look at what requirements the specific management task poses, and what opportunities it creates, and to be aware of what expectations and ideas are present, for example in the form of cultural values within a given organization. Greater complexity and variation in app

Mathematical models of cancer and bacterial evolution have generally stemmed from a gene-centric framework, assuming clonal evolution via acquisition of resistance-conferring mutations and selection of their corresponding subpopulations. More recently, the role of phenotypic plasticity has been recognized and models accounting for phenotypic switching between discrete cell states (e.g., epithelial

Despite improvements in treatment of mantle cell lymphoma (MCL), most patients eventually relapse. In this multicenter phase 1b/2 trial, we evaluated safety and efficacy of minimal residual disease (MRD)-driven venetoclax, lenalidomide, and rituximab (venetoclax-R2) in relapsed/refractory (R/R) MCL and explored the feasibility of stopping treatment in molecular remission. The primary end point was

Shedder status is defined as the propensity of an individual to leave DNA behind on touched items or surfaces and has been suggested as one of the major factors influencing DNA transfer. However, little is known about whether shedder status is a constant property of an individual across multiple measurements or when the environmental conditions are changed. We have assessed DNA depositions of six

Medical education should foster professionals with knowledge and skills, professional attitudes, and social responsibilities. Undergraduate and postgraduate education and continuing professional development as specialist each have unique possibilities and responsibilities. The use of varied assessment formats assist progression towards the expected program outcomes. An analysis of the main methods

Background: Apart from a consistent focus on treating inflammation, patients with inflammatory arthritis (IA) report a range of unmet needs. Many experience not only residual symptoms but also various other physical, psychological, and social effects. Therefore, this study aimed to develop a complex Interdisciplinary Nurse-coordinated self-management (INSELMA) intervention for patients with IA, as

Log messages are implemented by developers to record important runtime information about a system. For that reason, system logs can provide insight into the state and health of a system and potentially be used to anticipate and discover errors. Manually inspecting these logs becomes impractical due to the high volume of messages generated by modern systems. Consequently, the research field of mach

In large corporations, customer support is a costly service, and an area of constant optimization. Solutions to increase efficiency and decrease bottlenecks are constantly needed. One such bottleneck is support tool proficiency in a customer support organization where many different tools are used, and a potential solution is to let the tool guide the user as it is being used. This thesis explores

Background: Treatment of childhood glioma has evolved to reduce radiotherapy exposure with the goal of limiting late toxicity. However, the associations between treatment changes and neurocognition, and the contribution of neurocognition and chronic health conditions to attainment of adult independence, remain unknown. Methods: Adult survivors of childhood glioma diagnosed in 1970-1999 in the Chil

This paper explores how vacuum foam-drying of a protein is influenced by formulation parameters by investigating the foam structure, physical properties of the foam, and the stability of the protein. Recombinant human bile salt-stimulated lipase was used as a model of a protein drug. The stability of the lipase was evaluated through activity measurements. Two disaccharides (sucrose and trehalose),

Welfare capitalism has developed in the context of rapidly expanding, fossil fuel-driven industrial economies. Faced with the urgent need for systematic changes of economic systems so that they stay within planetary limits, decoupling welfare from economic growth is an important task. This chapter introduces the concept of sustainable welfare, referring to welfare systems that prioritise the satis

Scanning coherent X-ray microscopy (ptychography) has gained considerable interest during the last decade since the performance of this indirect imaging technique does not necessarily rely on the quality of the X-ray optics and, in principle, can achieve highest spatial resolution in X-ray imaging. The method can be easily extended to 3D by adding standard tomographic reconstruction schemes. Howev

Radionuclides released and discharged into the environment from nuclear and other radiation-related facilities, such as the European Spallation Source (ESS), may accumulate in aquatic bottom sediments. Sediments should therefore, as recommended by the IAEA, be monitored regularly. This report describes the setting up of a methodology for zero-point assessments of the radiation levels in sediments

The essay aims to find out how the greenery in Drottninghög affects the well-being of the residents, the concept of well-being is discussed and analyzed and in connection with the impact of greenery on well-being, the biophilia hypothesis is used as a theoretical framework. Furthermore, the impact of the physical design of housing estates is investigated and specifically the method around the Biot