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Luminescence dated loess-palaeosol sequences in the eastern Carpathian Basin reveal variable Holocene climate

Loess-palaeosol sequences (LPS) and loess like sediments are considered as some of the most significant terrestrial archives of climatic change and past atmospheric mineral dust activity. While these LPS have been widely used to investigate the immense climate disruptions of the last glacial period, relatively little attention has been directed toward the climate variability during the Holocene. Th

Late-onset epilepsy in survivors of childhood cancer outside the central nervous system : a study within the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study

Purpose: Although epilepsy has been reported in survivors of childhood cancer outside the central nervous system (CNS), little evidence exists on risk factors for this late complication. Our study aimed to identify risk factors of late-onset epilepsy. Methods: A case-cohort study was conducted within 5-year survivors of non-CNS childhood cancer from the Adult Life after Childhood Cancer in Scandin

Molecular Subtypes of Muscle-Invasive Bladder Cancer

An important tool for understanding the biology of muscle-invasive bladder cancer (MIBC) is molecular subtype classification. Molecular subtypes are qualitatively distinct biological entities that can be identified by molecular analysis of tumor tissue. This chapter describes how such entities have been discovered and described for MIBC and gives an overview of the characteristics that the luminal

Marketing in the anthropocene : A future agenda for research and practice

Marketing is an important function and practice in everyday business. It involves getting potential customers interested in a product or service through value-oriented arguments. In this way, marketing plays a pivotal role in driving the consumption of goods and services. Given the increasing consumption of goods and services, decreasing product lifetimes, and increasing levels of waste in all pro

Using Sentinel-2 time-series for land-use and evapotranspiration mapping in semi-arid Mediterranean areas : Tensift catchment, Morocco

The primary aim of this study is to estimate crop evapotranspiration (ETc) and develop a land use map to support the sustainable management of water resources in the irrigated Tassaout perimeter of Tensift. This is achieved by combining a time series of high spatial resolution Sentinel-2 satellite images, meteorological data, and field data. The method is based on the relationships between normali

Long on expectations, short on supply : Regional lithium imbalances and the effects of trade allocations by China, the EU, and the USA

Electric vehicles (EVs) are vital for a decarbonized society, but the rapid growth of the EV market highlights an impending lithium supply crisis. This study integrates supply-demand analysis with trade network simulations, using eight lithium demand scenarios and two supply scenarios to examine regional lithium dynamics and the impact of international trade. Results show that while domestic lithi

In Vitro Elimination of Highly Multidrug-Resistant Bacteria by the Lactic Acid Bacterial Drug Candidate ILP100

Introduction: Multidrug resistance (MDR) has been identified in wound bacterial isolates from Ukrainian war victims treated in Ukraine and across Europe. ILP100, a drug candidate for the treatment of skin wounds, is composed of a Limosilactobacillus reuteri expressing human chemokine CXCL12. In this study, the antimicrobial effects of ILP100 were tested on MDR bacteria isolated from wounds of Ukra

Fine-mapping in admixed populations using CARMA-X, with applications to Latin American studies

Genome-wide association studies (GWASs) in ancestrally diverse populations are rapidly expanding, opening up unique opportunities for novel gene discoveries and increased utility of genetic findings in non-European individuals. A popular technique to identify putative causal variants at GWAS loci is via statistical fine-mapping. Despite tremendous efforts, fine-mapping remains a very challenging t

European S2k Guideline on Chronic Pruritus : In cooperation with the European Dermatology Forum (EDF)

Pruritus is a frequent symptom in medicine. Population-based studies show that one in five persons in the general population has suffered from chronic pruritus (CP) at least once in their lifetime, with a 12-month incidence of 7%. CP, which can affect all age groups, is associated with numerous, often interdisciplinary medical conditions. It needs a precise diagnostic work-up to identify causes an

Examining Platform Owner Compliance and Autonomous Complementor Behavior in Open Banking Platforms

The revised Payment Services Directive (PSD2) by the EU is disrupting banks and requiring them to provide third-party providers (TPPs) access to customer data. PSD2 aims to promote innovation and competition by enabling TPPs to leverage data to develop payment services. To comply, banks develop platforms where TPPs can use APIs to access data. This is described as open banking, marking a shift tow

Entry Barriers and Opportunities for Fintechs in Open Banking Platforms

The revised Payment Services Directive (PSD2) is reshaping traditional banking by requiring banks to grant licensed third-party providers (TPPs) access to customer data. This paper explores PSD2’s impact on Fintech market entry, assessing both opportunities and ongoing structural barriers. Through a qualitative investigation, it identifies key barriers such as API standardization gaps, data access

Play together, stay together. : Musical progress and social inclusion in group instrumental teaching.

This thesis explores how teachers in Sweden’s art and music schools navigate the potentially conflicting goals of musical progress and social inclusion in group instrumental teaching. Group teaching has gained popularity due to cost-efficiency and its potential to meet children's social needs. However, many teachers trained in the one-to-one conservatory tradition express concern about maintaining

Sacrificial redox modulation by a secreted bacterial effector molecule mitigates oxidative stress and inflammation in vivo

Human-bacterial interactions play a crucial role in several essential aspects of life. Here, we describe how a secreted protein from the skin commensal Cutibacterium acnes, RoxP, functions as a sacrificial redox effector molecule that facilitates beneficial interactions with its human host by counteracting oxidative stress and reducing stress-induced inflammation. Using a combination of structural

Generalized Group Delay Weighted Sparse Time–Frequency Analysis for Transient Signals

Time-frequency (TF) postprocessing methods are often used to form concentrated TF representations (TFRs) for nonstationary signals. Regrettably, most such techniques are sensitive to noise and tend to underestimate weak components when dealing with transient signals, resulting in sidelobes and low-resolution TFRs. In this work, we introduce a generalized group delay (GD) weighted sparse TF (GWSTF)