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Most bones of the human body form and heal through endochondral ossification, whereby hypertrophic cartilage (HyC) is formed and subsequently remodeled into bone. We previously demonstrated that HyC can be engineered from human mesenchymal stromal cells (hMSC), and subsequently devitalized by apoptosis induction. The resulting extracellular matrix (ECM) tissue retained osteoinductive properties, l

This study describes the production, characterization and structure determination of a novel Holliday junction-resolving enzyme. The enzyme, termed Hjc_15-6, is encoded in the genome of phage Tth15-6, which infects Thermus thermophilus. Hjc_15-6 was heterologously produced in Escherichia coli and high yields of soluble and biologically active recombinant enzyme were obtained in both complex and de

In 2016, the European Hematology Association (EHA) published the EHA Roadmap for European Hematology Research1 aiming to highlight achievements in the diagnostics and treatment of blood disorders, and to better inform European policy makers and other stakeholders about the urgent clinical and scientific needs and priorities in the field of hematology. Each section was coordinated by 1–2 section ed

I den här artikeln redogör Axel Hilling, Niklas Sandell, Amanda Sonnerfeldt och Anders Vilhelmsson för utvecklingen av offentlig land-förlandrapportering av skatter inom EU. Författarna analyserar hur den aktuella regleringen förhåller sig till EU:s nya direktiv för hållbarhetsrapportering, Corporate Sustainability Reporting Directive, CSRD.

Objectives To compare risks for COVID-19-related outcomes in inflammatory joint diseases (IJDs) and across disease-modifying antirheumatic drugs (DMARDs) during the first two waves of the pandemic and to assess effects of the pandemic on rheumatology care provision. Methods Through nationwide multiregister linkages and cohort study design, we defined IJD and DMARD use annually in 2015-2020. We ass

The ability to harvest reducing power from molecular hydrogen was once considered a prokaryotic trait. New research challenges this notion by finding the first eukaryotic organism capable of oxidizing hydrogen.

IntroductionFloods are the most common type of natural disaster worldwide and are projected to become morefrequent and more extreme. Cambodia is prone to annual, seasonal flooding. Floods impact health inmany ways and can disrupt the health system through destruction of infrastructure and loss ordiversion of human, economic and physical resources. Through knowledge acquisition and skillsdevelopmen

This book comprises the select proceedings of the International Conference on Future Learning Aspects of Mechanical Engineering (FLAME 2020). This volume focuses on current research in fluid and thermal engineering and covers topics such as heat transfer enhancement and heat transfer equipment, heat transfer in nuclear applications, microscale and nanoscale transport, multiphase transport and phas

Glaucoma is a potentially blinding disease where the affected individual often firstnotices symptoms when the disease has reached a late stage. If glaucoma is detectedearly e.g., at screening, the risk for visual impairment can be reduced. There are manyfactors that affect a patient´s risk of developing glaucoma or visual impairment due toglaucoma. In the four studies of this thesis, the general a

The authors of this paper reinvestigate the remains of the Basilica Sempronia, situated below the Imperial Basilica Julia in Rome. By combining the information from the original excavation with a new 3D digital documentation, new observations are made and previous interpretations reassessed. The present remains are discussed in relation to the contemporary built environment, as well as to precedin

Episodes of economic shrinking have declined since the 1980s in Latin America and the Caribbean (LAC). This paper asks why. We propose that the reduction in the frequency and rate of shrinking reveals the dynamic transition from being natural states towards becoming open access societies. To provide empirical support to the argument, we rest on the notion of social capabilities. Hence, societies t

Experimental field measurements regarding airtightness following the fan pressurisation method were done on 25 typical residential buildings at different locations in Nepal. The field measurement data were classified according to building type and building age.The mean air permeability (Q50 ) for the studied buildings was 6.9 l/s·m2 and the mean air change rate was 55.5 air changes per hour at 50

The adsorption of organic micropollutants onto powdered activated carbon (PAC) was investigated in laboratory scale based on samples from four wastewater process streams (matrices); three from a pilot-scale plant with different degrees of physicochemical treatment of municipal wastewater and one from a full-scale activated sludge plant with post-precipitation. The pilot-scale treatment consisted o