Tumors are complex entities, composed of different functional populations of malignant and stromal cells. There is an emerging importance to understand previously unmapped communication routes between different cell and non-cell compartments of the tumor microenvironment. Targeted drugs have been used for years in an attempt to block essential pathways for tumor growth. Specifically, drugs targeti

Numerous auto-scaling strategies have been proposed in the past few years for improving various Quality of Service (QoS) indicators of cloud applications, for example, response time and throughput, by adapting the amount of resources assigned to the application to meet the workload demand. However, the evaluation of a proposed auto-scaler is usually achieved through experiments under specific cond

The National Environmental Objectives (NEOs) adopted by Swedish Parliament in 2001 and proclaimining that major environmental problems should be solved within a generation are often portrayed as good practice of a concrete yet visionary sustainability strategy. In this paper we summarize one and a half decade of the NEOs' experience for the international audience. The NEOs were based on an eclecti

BACKGROUND: Children with problematic severe asthma have poor disease control despite high doses of inhaled corticosteroids and additional therapy, leading to personal suffering, early deterioration of lung function, and significant consumption of health care resources. If no exacerbating factors, such as smoking or allergies, are found after extensive investigation, these children are given a dia

Recent studies suggest that increases in extent and duration of winter soil frost increases dissolved organic carbon (DOC) concentrations in boreal riparian soils and connected aquatic systems during the subsequent spring and summer. However, little is known about the impact of frost on DOC character and its degradability. We applied three experimental treatments to riparian soils in northern Swed

Although training and development is recognized as an important means to nurture corporate entrepreneurs in organizations, extant research has focused primarily on efforts to develop entrepreneurial leaders and nurture business creation in a school or university setting. We report on the findings of an inductive case study of corporate entrepreneurship training in a large multinational corporation

'Sustainability' is an emerging issue that product development engineers must engage with to remain relevant, competitive and, most importantly, responsible. Yet, on examining the term 'sustainable', a plethora of definitions emerges, many of which are contradictory and confusing. This confusion and a general lack of understanding means that sustainability often gets relegated to an afterthought o

Resolving complexes of closely related and cryptic insect species can be challenging, especially when dealing with rare and protected taxa that are difficult to collect for genetic and morphological analyses. Until recently, populations of the genus Osmoderma (Scarabaeidae), widespread in Europe, were treated as a single species O. eremita (Scopoli, 1763) in spite of observed geographic variation

Genetic studies of complex traits have become increasingly successful as progress is made in next-generation sequencing. We aimed at discovering single nucleotide variation present in known and new candidate genes for developmental dyslexia: CYP19A1, DCDC2, DIP2A, DYX1C1, GCFC2 (also known as C2orf3), KIAA0319, MRPL19, PCNT, PRMT2, ROBO1 and S100B. We used next-generation sequencing to identify si

Regulated transcription controls the diversity, developmental pathways and spatial organization of the hundreds of cell types that make up a mammal. Using single-molecule cDNA sequencing, we mapped transcription start sites (TSSs) and their usage in human and mouse primary cells, cell lines and tissues to produce a comprehensive overview of mammalian gene expression across the human body. We find

The photon-induced Auger and photoelectron spectra of the argonlike ions Cl- (in NaCl), K+ (in KCl), Ca2+ (in CaCl2 and CaF2), and Sc3+ (in Sc2O3) have been measured in the vicinity of the L23 absorption edges of these ions. It is shown that at the 2p6→2p53d(4s) resonance a spectator structure appears in the L23M23M23 Auger spectra, which shifts to higher kinetic energies with increasing photon en

This project offers an initial evaluation of using the online learning platform Prezi as a tool for increasing student learning within a MA unit in human geography. It does this by comparing the use of Prezi to four other learning activities conducted during the course. The aim of the project is to see whether the use of this technology became an end in itself, thereby distracting students and det

Wildfire has become a major disturbance agent in Mediterranean area, with Galicia in the north-west of Spain having the most frequent fires. In order to combat soil erosion, different post-fire stabilization treatments can be applied, like adding different mulch materials. In a laboratory experiment we evaluated the effect of adding plant residues, commonly used in post-fire rehabilitation (wheat

This paper adds to the relatively few European studies on the pedestrian friendliness of urban areas, and on transport walking. Using the Human Environment Interaction (HEI) model (Küller, 1991), the study explores the associations between perceived neighbourhood spatialphysical and social environment qualities and walking to neighbourhood destinations, and examines whether these associations are

Sustainability professionals are agents for change towards sustainable development. Such professionals require knowledge from a variety of disciplines, but also competencies to accomplish real-word change. This article evaluates an innovative course, Strategic Environmental Development, which immerses students in a real-life solution-oriented consultancy project in order to develop critical sustai