The clinical pharmacokinetics of AZD3199, an ultra-long-acting β2-agonist, were investigated in healthy volunteers and patients with asthma or chronic obstructive pulmonary disease (COPD).

We examine the case of Denmark - a country which historically had next to no domestic energy resources - for which we present new historical energy accounts for the years 1800-1913. We demonstrate that Denmark’s take off at the end of the nineteenth century was relatively energy dependent. We relate this to her well-known agricultural transformation and development through the dairy industry, and

A search for single top quark production is performed in the full e(+/-)p data sample collected by the H1 experiment at HERA, corresponding to an integrated luminosity of 474 pb(-1). Decays of top quarks into a b quark and a W boson with Subsequent leptonic or hadronic decay of the W are investigated. A multivariate analysis is performed to discriminate top quark production from Standard Model bac

The EU has assumed ambitious targets and strategies for the promotion of renewable sources of energy (RES) binding to all its member states. This report examines the proposed EU-wide policy instrument designed to help achieve the targets on renewable electricity and heat - the trading of Guarantees of Origin (GO). It analyses the rise and fall of the GO trading proposal in the European policy-maki

Pinhole collimation is the most common method of high-resolution preclinical single photon emission computed tomography imaging. The collimators are usually constructed from dense materials with high atomic numbers, such as gold and platinum, which are expensive and not always flexible in the fabrication step. In this work, the authors have investigated the properties of a fusible alloy called Ros

The objective of this study was to test if apatite amendment stimulates growth of ectomycorrhizal (EM) fungi and if this is influenced by the phosphorus status of the forest. The production of EM mycelia was estimated in four Norway spruce forests in south-western Sweden by incubating sand-filled mesh bags (with or without apatite amendment) in the soil for 8 or 20 months. Fungal biomass in the me

Background: SoPIP2;1 constitutes one of the major integral proteins in spinach leaf plasma membranes and belongs to the aquaporin family. SoPIP2;1 is a highly permeable and selective water channel that has been successfully overexpressed and purified with high yields. In order to optimize reconstitution of the purified protein into biomimetic systems, we have here for the first time characterized

This paper addresses the problem of reproducing the effect of different visibility conditions on people’s walking speed when using evacuation models. In particular, different strategies regarding the use of default settings and embedded data-sets are investigated. Currently, the correlation between smoke and walking speed is typically based on two different sets of experimental data produced by (1

We present a study of the drift, in terms of cantilever deflections without probe/target interactions, of polymeric SU8 cantilevers. The drift is measured in PBS buffer (pH 7.4) and under vacuum (1mbar) conditions. We see that the cantilevers display a large drift in both environments. We believe this is because the polymer matrix absorbs liquid in one situation whereas it is being degassed in the

Fusobacterium necrophorum is a well-known cause of Lemirre's disease and accumulating evidence support its pathogenic role in peritonsillar abscess while its role in recurrent and chronic tonsillitis is uncertain. The objective of this study was to assess the prevalence of oropharyngeal colonisation with F. necrophorum and Beta-haemolytic streptococci in a cohort of patients scheduled for tonsille

Injury to the brain (e.g., stroke) results in a disruption of neuronal connectivity and loss of fundamental sensori-motor functions. The subsequent recovery of certain functions involves structural rearrangements in areas adjacent to the infarct. This remodeling of the injured brain requires trafficking of macromolecular components including cholesterol and phospholipids, a transport carried out b

Microemulsions based on nonionic surfactants of the ethylene oxide alkyl ether type C(m)E(n), have been studied thoroughly for around 30years. Thanks to the considerable amount of published data available on these systems, it is possible to observe trends to make predictions of phase diagrams not yet determined. Strey and Kahlweit, and subsequently Sottmann and Strey, with coworkers have studied a

This dissertation contains three independent studies that analyze labor markets in transformation. They focus on two central elements of labor markets in developing countries: non-agricultural employment in the rural economy and informal employment in the urban economy. Rural non-agricultural employment (RNAE) is being increasingly emphasized as a potential pathway out of rural poverty for people

BACKGROUND: Advanced glycation end products (AGE) and their receptors (RAGE) have been implicated in cancer development through their proinflammatory capabilities. However, prospective data on their association with cancer of specific sites, including pancreatic cancer, are limited.METHODS: Prediagnostic blood levels of the AGE product Nε-(carboxymethyl)lysine (CML) and the endogenous secreted rec

The present article reports on static and dynamic light scattering (SLS and DLS) studies of aqueous solutions of the nonionic surfactant C12EO6 and the poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer EO20PO68EO20 (P123) at temperatures between 25 and 45 degrees C. In water, P123 self-assembles into spherical micelles with a hydrodynamic radius of 10 nm, and at 40

We present a dual-focus second harmonic generation (SHG) microscopy approach based on stable, compact, and inexpensive fiber technology. One-tenth of the fiber laser output is coupled into a 100 m (=500 ns) long single-mode fiber and further amplified to achieve two separately guided beams with time-alternating pulse trains. SHG detection is performed sequentially, generating two individual images

Den svenska kristna missionen i Indien under 1800-tal och tidigt 1900-tal. Familjen Blomstrands korrespondens mellan Indien coh Sverige.

Popular Abstract in Swedish Diabetes är en endokrin sjukdom som också kallas sockersjuka. Den kännetecknas av förhöjda mängder socker i blodet. Halten av socker i blodet, blodsockret, styrs av hormonet insulin, som produceras av β-celler i Langerhanska öar i bukspottskörteln. När insulin frisätts stimuleras muskler, fettväv och lever till att ta upp glukos ur blodet och lagra det. På så sätt sänksType 2 Diabetes (T2D) prevalence is growing to pandemic proportions worldwide. The link between genotype, environment and β-cell function is still being investigated. I have devoted the work presented in this thesis to attempt to elucidate the coupling of β-cell metabolism to insulin secretion and to look for casual mechanisms underlying metabolic alterations disturbing insulin secretion. In paper