Lysine methylation is an important and much-studied posttranslational modification of nuclear and cytosolic proteins but is present also in mitochondria. However, the responsible mitochondrial lysine-specific methyltransferases (KMTs) remain largely elusive. Here, we investigated METTL12, a mitochondrial human S-adenosylmethionine (AdoMet)-dependent methyltransferase and found it to methylate a si

Hsp70 proteins constitute an evolutionarily conserved protein family of ATP-dependent molecular chaperones involved in a wide range of biological processes. Mammalian Hsp70 proteins are subject to various post-translational modifications, including methylation, but for most of these, a functional role has not been attributed. In this study, we identified the methyltransferase METTL21A as the enzym

The Arctic has warmed more than twice as fast as the global average since the late twentieth century, a phenomenon known as Arctic amplification (AA). Recently, there have been considerable advances in understanding the physical contributions to AA, and progress has been made in understanding the mechanisms that link it to midlatitude weather variability. Observational studies overwhelmingly suppo

Katalog till utställning på Gripsholms slott om Gustaf Adolf Reuterholms porträtt. Behandlar alla typer av porträtt i den största kända samlingen av enskilda avbildningar av enskild svensk.

Background: Epilepsy patients commonly exercise less than the general population. Animal studies indicate beneficial effects of physical activity in established epilepsy, while its effect on the development is currently less known. Methods: Here, we investigated the incidence of epilepsy during 20 years in a cohort of participants from the long-distance Swedish cross-country ski race Vasaloppet (n

We demonstrate the generation and in-situ measurement of the electric field and CEP of intense near-single-cycle laser pulses using the new optical technique of CEP dispersion-scan.

The gender-neutral third-person pronoun singular hen was recently introduced in Swedish as a complement to she (hon) and he (han). The initiative to add hen initially received strong criticism. In the present study, we analyzed 208 arguments from 168 participants with critical attitudes toward hen. We used Blaubergs’ (1980) and Parks and Roberton’s (1998) taxonomies of critical arguments against p

This paper combines numerical and experimental to study the heat transfer by free convection for nanofluids of molten salt within a cavity with cylindrical shape which is heated at the bottom and releases heat at the top. The aim is to acquire the free convection laws for nanofluids of molten salt in a cylindrical cavity. It is found that after adding nanoparticles, the molten salts have lower vis

The lower Borgarfjörður region, western Iceland, has been central to the reconstructions of the dynamics and collapse of the Icelandic Ice Sheet during the deglaciation. Here, extensive stratigraphical sections and landforms provide a rare opportunity to study past glacier dynamics in this part of Iceland. Previous studies reveal that a large outlet glacier in Borgarfjörður advanced during the Lat

DivIVA is a crucial membrane-binding protein that helps to localize other proteins to negatively curved membranes at cellular poles and division septa in Gram-positive bacteria. The N-terminal domain of DivIVA is responsible for membrane binding. However, to which lipids the domain binds or how it recognizes the membrane negative curvature remains elusive. Using computer simulations, we demonstrat

This article argues that the depictions of Gnostic sects performing horrendous rites in Epiphanius of Cyprus’ work Panarion worked as rhetorical devices to shift focus away from his own position vis-à-vis marriage, sex, and consumptions of good food and wine, a position that was considered liberal in the context of fourth century eccle- siastical debates. It here is shown how Epiphanius’ descripti