Type 2 diabetes (T2D) is a global pandemic. Genome-wide association studies (GWASs) have identified >100 genetic variants associated with the disease, including a common variant in the melatonin receptor 1 b gene (MTNR1B). Here, we demonstrate increased MTNR1B expression in human islets from risk G-allele carriers, which likely leads to a reduction in insulin release, increasing T2D risk. Accordin

En diskussion av filmmusikkompositören Bernard Herrmanns musik. Herrmann, som är mest känd för sitt samarbete med Orson Welles och Alfred Hitchcock, skapade en musik som mer än andra kompositörer satte sin unika prägel på de projekt han var involverad i. Texten diskuterar hans sätt a skapa ett samspel mellan ljud och bild genom att bryta upp musikens ledmotiv i mindre, kortare, fraser, för att på

Texten är en diskussion av kompositionella aspekter på film med centralperspektivet som utgångspunkt. Detta jämförs med parallellperspektivet som kom till Europa från framförallt Japan och kom att utgöra ett dominerande inflytande på den europeiska modernismen inom måleriet. Vid sidan om rent kompositionella aspekter diskuteras i texten zoom estetiken och den ursprungligen oavsiktliga perspektivfö

Molecularly imprinted polymers (MIPs) have been developed mostly for the specific binding of the target, mimicking the function of antibodies. In addition to these " plastic antibodies," completely synthetic catalysts have been created that mimic substrate conversion by enzymes. In this chapter, the following examples will be presented: (1) an esterolytic MIP for phenolic esters that is prepared u

This report has been translated from Swedish and adapted for an international audience. The original report, Leadership for quality in doctoral education1, was commissioned by the Association of Swedish Higher Education. Here we describe and discuss doctoral education as policy, practice and as an object of knowledge, and highlight a number of questions that are important for the management and le

A discussion of inherent limitations in early live television, the methods necessary in live productions and aesthetic consequences that live TV resulted in.

The text emphasizes aesthetics in post war American film and is more precisely a study of directors, which started their career within live television and made a transition to cinema. The influence of their television background on their films is central to the text. Contributing factors in this context are changes in the overall technology within TV, changes from live productions to the use of fi

Inside-out submitochondrial particles (IO-SMP) were isolated and purified from potato (Solanum tuberosum L. cv.) tubers. When these IO-SMP were incubated with [γ32P]ATP more then 20 proteins became labelled as a result of phosphorylation. The 32P incorporation was stimulated by the oxidizing reagent ferricyanide. Except for a 17 kDa protein which was phosphorylated only in the absence of divalent

For the first time, to our knowledge, a nucleoside diphosphate kinase (NDPK) has been purified from plant mitochondria (Pisum sativum L.). In intact pea leaf mitochondria, a 17.4-kDa soluble protein was phosphorylated in the presence of EDTA when [γ-32]ATP was used as the phosphate donor. Cell fractionation demonstrated that the 17.4-kDa protein is a true mitochondrial protein, and the lack of acc

Inside-out submitochondrial particles from potato tuber mitochondria were incubated with [γ-32P]ATP. More than 16 phosphorylated polypeptides were detected by autoradiography on an SDS-gel. Two phosphoproteins, migrating at 22 and 28 kDa, were excised from the SDS-gel, electroeluted, and purified further by anion chromatography. The phosphoproteins were N-terminally sequenced. Over the regions seq

Lignin is a major component of lignocellulosic biomass and as such, it is processed in enormous amounts in the pulp and paper industry worldwide. In such industry it mainly serves the purpose of a fuel to provide process steam and electricity, and to a minor extent to provide low grade heat for external purposes. Also from other biorefinery concepts, including 2nd generation ethanol, increasing am

Biografisk skildring av lundaalumnen och konstnären Wilhelm Angeldorff (1864-?) inklusive uppgifter om dennes föräldrar Christopher Olofsson Angeldorff (1808-1866) och Helène Angeldorff, född Österberg (1832-1911).