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Aim: The aim of present study is to investigate the binding characteristics of non-peptide calcitonin gene-related peptide (CGRP) receptor antagonists (i.e., gepants) in the brain membranes of rat, pig and human. Methods: The interaction of available gepants with the CGRP receptor was studied in the brain membranes of 3 different species using a radioligand competitive binding assay. In addition,

Introduction: Repetitive negative thinking (RNT) is reported in a wide variety of emotional disorders, although it is most often associated with either depression or anxiety disorders, assessed as symptoms of rumination and worry. Early detection of indicators for RNT across disorders is needed. To this end we explored the psychometric properties of a transdiagnostic measure, i.e., the Swedish ver

In Western societies, with increasingly salient mediation processes, eating, too, has become an entanglement of offline and online practices. Food as carrier of values has never merely satisfied bodily needs, which makes it essential to investigate mediated eating practices and emerging digital foodscapes in order to understand how they change everyday life, but also culture at large. However, mos

The underlying mechanism(s) behind the potential carcinogenicity of processed meat is a popular research subject of which the lipid oxidation is a common suspect. Different formulations and cooking parameters of a processed meat product were evaluated for their capacity to induce lipid oxidation. Meatballs made of beef or pork, containing different concentrations of fat (10 or 20 g 100 g−1), salt

Most of the physics (as well as the other sciences) taught in school can be described as well-established or consensus science. This is the kind of science knowledge that was mostly developed over a century ago. The inclusion of contemporary science research in compulsory school science teaching could be justified from a variety of reasons: increasing students' interest and motivation; providing i

The pest Plodia interpunctella (Hübner) is reared in many research laboratories. In a culture established in 1996, attraction of males to the female-produced sex pheromone in flight tunnel assays gradually decreased after ≈15 years of rearing. A new culture was established to enable comparison with the old culture regarding traits associated with mate finding. Female calling activity, pheromone ti

Background: Lung cancer is one of the most common cancers in the world. Early detection and correct staging are fundamental for treatment and prognosis. Positron emission tomography with computed tomography (PET/CT) is recommended clinically. Silicon (Si) photomultiplier (PM)-based PET technology and new reconstruction algorithms are hoped to increase the detection of small lesions and enable earl

This summary refers to the paper 'Comparison of the FMEA and STPA safety analysis methods-a case study' [Su17]. The paper was published as an article in the Software Quality Journal. It compares the Failure Mode and Effect Analysis (FMEA) and the System Theoretic Process Analysis (STPA) in an industrial case study.

Omsorg och kärlek, empati och omtanke är grundläggande inslag i mänskliga relationer. Vi känner igen dem som autentiska uttryck i en personlig relation. Men vilka möjligheter har barmhärtighet och medmänsklighet att komma till uttryck i institutioner som är uppbyggda av lagar, regler och principer? Med andra ord, kan barmhärtigheten institutionaliseras, eller är en medmänsklig livshållning förbehå

Tactile displays have a wide range of applications in assistive technology, prosthetics, and rehabilitation. Vibrotactile stimulation shows potential to be integrated into wearable devices because of its small size, low power consumption, and relative fast responding speed. In this paper, experiments investigating vibrotactile minimal detectable level, just noticeable difference, and two point dis

The use of prosthetic hands is limited in part by the lack of sensory feedback to the wearer. In order to provide sensory feedback, an adequate number of sensors must be integrated with the prosthesis. The WiseSkin project targets the use of artificial skin embedding ultra-low power wireless sensor nodes. This presentation provides an overview of the WiseSkin project and the current status of the

Pax Syriana provides readers with a broad picture of what has changed, and what has failed to change, in the Lebanese political system after the end of the civil war.

Background: Arterial stiffness is known to be associated with a number of clinical conditions including hypertension, diabetes and dyslipidemia, and may predict cardiovascular events and mortality. However, causal links are hard to establish. Results from genome-wide association studies have identified only a few single nucleotide polymorphisms associated with arterial stiffness, the results have