Heparan sulfate (HS)-containing, S-nitrosylated (SNO) glypican-1 (Gpc-1) releases anhydromannose-containing HS (anMan-HS) by SNO-catalyzed autodegradation in endosomes. Transport of anMan-HS to the nucleus requires processing of the amyloid precursor protein (APP) to amyloid beta peptides (Aβ). To further examine the relationship between APP and Gpc-1 processing in normal fibroblasts we have suppr

The number of CT examinations giving a relatively high patient exposure is increasing. It is therefore important to optimize the imaging conditions at these investigations. Many steps have been taken to reduce the radiation doses in CT examinations. Currently much work is related to iterative image reconstruction methods as alternative to the filtered back projection method. The aim of this work w

BACKGROUND: Isolated thylakoid membranes, i.e. the photosynthetic membranes of green leaves, inhibit the activity of pancreatic lipase and colipase during hydrolysis of fat in vitro. This inhibition has been demonstrated to cause reduced food intake and improved hormonal and lipid profile in vivo. One of the reasons suggested for the inhibiting effect is binding of lipase-colipase to the thylakoid

Detailed family history offers an inexpensive alternative to genetic profiling for individual risk assessment. The objective here was to update the Prostate Cancer Prevention Trial Risk Calculator (PCPTRC) to include detailed family history.

There are few data on the joint influence of metabolic factors on risk of separate cancers.

Genome editing via CRISPR/Cas9 has rapidly become the tool of choice by virtue of its efficacy and ease of use. However, CRISPR/Cas9-mediated genome editing in clinically relevant human somatic cells remains untested. Here, we report CRISPR/Cas9 targeting of two clinically relevant genes, B2M and CCR5, in primary human CD4(+) T cells and CD34(+) hematopoietic stem and progenitor cells (HSPCs). Use

We present a comprehensive analysis of autoionization processes in Ne clusters (similar to 5000 atoms) after multiple valence excitations by free electron laser radiation. The evolution from 2-body interatomic Coulombic decay (ICD) to 3-body ICD is demonstrated when changing from surface to bulk Frenkel exciton excitation. Super Coster-Kronig type 2-body ICD is observed at Wannier exciton which qu

To compare structural knee joint changes in obese patients with knee osteoarthritis (OA) that after an intensive weight loss therapy were randomized to continuous dietetic support, a specialized knee exercise program, or 'no attention' for 1 year.

There is a strong genetic predisposition towards abdominal aortic aneurysm (AAA), but it is unknown whether persons without AAA but with first-degree relatives who are AAA patients have a generalized dilating diathesis, defect arterial wall mechanics, or increased cardiovascular risk. The aim of the study was to investigate arterial diameters and wall mechanics at multiple arterial sites in these

We prove an operator identity for the shift operator in the scale of standard weighted Bergman spaces in the unit disc. This operator identity is then applied in the context of functional calculus for the shift operator and a characterization of harmonic symbol Bergman space Toeplitz operators is obtained generalizing an earlier result by Louhichi and Olofsson. Duality arguments lead to operator i

This article explores the ever-shifting semantics and semiotics of the concept “indígena” in the Bolivian Andes, and argues that “indigeneity” is charged with different meanings by different actors in changing contexts of territorial and social struggles and state governance. The article focuses on the discourse and politics of the indigenous Andean organization CONAMAQ and its response to changi

Present trends in the mainstream adoption of educational technology coupled to the increased acceptance and adoption of openness in terms of sharing resources and open access force higher education into a radical rethink of its structures and educational strategies. This article examines the current shift in focus from the simple production and sharing of open educational resources (OER) towards w

In this paper, we discuss the effects of jumps in data on causation pattern both in mean and variance. Our data consist of daily stock returns of four countries: the US, the UK, Japan and Sweden and used for empirical investigation. A test proposed by Cheung and Ng (1996) and Hong (2001) is used for testing volatility spillover. We find significant evidence of jump spillover. It is shown that the

We report on the first in situ synchrotron radiation powder X-ray diffraction study (SR-PXD) of the ammonolysis reaction of selected alkaline and alkaline earth metal hydrides (i.e., LiH, NaH, KH, MgH2, and CaH2). The investigation was performed using an in situ SR-PXD pressure cell at an initial NH3 pressure of 6.5 bar in a range of temperature between room temperature (RT) and 350 degrees C. The

Results are presented on the production of jets of particles in association with a Z/gamma* boson, in proton-proton collisions at root s = 7 TeV with the ATLAS detector. The analysis includes the full 2010 data set, collected with a low rate of multiple proton-proton collisions in the accelerator, corresponding to an integrated luminosity of 36 pb(-1). Inclusive jet cross sections in Z/gamma* even

Background The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain. Methods We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in

Femtosecond time-resolved core-level photoemission spectroscopy with a free-electron laser is used to measure the atomic-site specific charge-order dynamics of the charge-density wave in the Mott insulator 1T-TaS2. After strong photoexcitation, a prompt loss of charge order and subsequent fast equilibration dynamics of the electron-lattice system are observed. On the time scale of electron-phonon

It has been argued that the decay rates of several radioactive nuclides are slightly lower at Earth's aphelion than at perihelion, and that this effect might depend on heliocentric distance. It might then be expected that nuclear decay rates be considerably lower at larger distances from the sun, e.g., in the asteroid belt at 2-3 AU from where most meteorites originate. If so, ages of meteorites o

Intraoral target (typing) and on-screen target (pointing/tracking) selection tasks were performed by 10 participants during 3 consecutive day sessions. Tasks were performed using 2 different intraoral sensor layouts. Reduction of undesired sensor activations while speaking as well as the influence of intraoral temperature variation on the signals of the intraoral interface was investigated. Result