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Objective: To evaluate the safety and endometrial protection of low-dose transdermal estradiol (E2)/norethisterone acetate (NETA) patches (Estalis 25/125) in terms of post-treatment incidence of endornetrial hyperplasia/cancer after 1 year of treatment in postmenopausal women with intact uteri. Methods: Patients were randomized to receive either transdermal E2/NETA (delivering daily doses of E2 25

The relation between clinical or histologic chorioamnionitis and early neonatal adverse neurologic outcome was investigated (n = 483). Histologic, but not clinical, evidence of chorioamnionitis was found to be a significant predictor of periventricular echodensity (odds ratio, 2.4; 95% CI, 1.8-3.2), echolucency (3.3; 1.9-5.6), ventriculomegaly (2.7; 1.8-4.2), intraventricular hemorrhage > or =3 (3

Several transcripts have been claimed to be clinically valuable for detecting minimal disease in neuroblastoma, but they have not been prospectively compared in a standardized manner. Tyrosine hydroxylase (TH), dopa decarboxylase (DDC) and GD2 synthase (GD2S) mRNAs were analyzed in 554 blood (PB) and bone marrow (BM) samples from 58 children with neuroblastoma. Samples from 44 children with other

The driving force behind oncoproteomics is to identify biomarker signatures associated with a particular malignancy. Here, we have for the first time used large-scale recombinant scFv antibody microarrays in an attempt to classify metastatic breast cancer versus healthy controls, based on differential protein expression profiling of whole serum samples. Using this multiplexed and miniaturised assa

In post-World War II agricultural research, a new perspective on "peasant society" developed. This approach is still vigorous today and implies that peasant society defined by subsistence production, the safety-first principle, and a stable village system with moral obligations-leads to conservative behavior toward change. It also assumes that only external forces can tear down the system and forc

PEG self-diffusion coefficients of poly(ethylene glycol)s (PEGs) (1080, 8500, and 82 250 g/mol) were measured by PFG-NMR spectroscopy in whey protein solutions and gels in relation to whey protein concentration effects (from 6.49 to 40.45 g/100 g) and whey protein heat denaturation effects (30 min at 70 degrees C). A strong dependency of diffusion on probe size was observed in both whey protein so

OBJECTIVE: Firstly, is the negative psychological effect of obesity also present in the whole population of obese and overweight children? Secondly, what tools could be recommended to measure the psychological effects of obesity? DESIGN: Review. METHODS: Quality of life or self-esteem is often used in evaluating the psychological effects of obesity. Test instruments used have been instruments for

Treatment of prostatic carcinoma with estrogens is accompanied by an increased risk for thromboembolic and cardiovascular complications. The underlying mechanisms are still unknown. Patients treated with diethylstilbestrol (DES) were compared with patients given no estrogen treatment regarding factors (platelet aggregation in vitro and plasma lipoproteins) that have been suggested to contribute to

Mating is costly for both male and female insects and should therefore only occur if it is likely to be successful. Within one scotophase, which is the dark period of the light cycle, male moths can only produce one single spermatophore, which is transferred to the female during mating. Remating within the same scotophase would thus be unsuccessful. We tested the hypothesis that newly mated males

Theoretical studies on hyperfine-interaction-dependent lifetimes of the 4s4p P-3(2) states of Zn-like ions are reported in this paper. A systematic investigation along the isoelectronic sequence shows that the lifetime of the 4s4p P-3(2) level is very sensitive to hyperfine interaction at the beginning of the sequence, but gets less sensitive going to the higher end. The intensity ratio between th

A new frontier of discrete-line gamma-ray spectroscopy at ultrahigh spin has been opened in the rare-earth nuclei Er-157,Er-158. Four rotational structures, displaying high moments of inertia, have been identified, which extend up to spin similar to 65h and bypass the band-terminating states in these nuclei which occur at similar to 45h. Cranked Nilsson-Strutinsky calculations suggest that these s

A mutant lacking the ability to express the surface-exposed lipoprotein protein D was constructed by linker insertion and deletion mutagenesis of a cloned DNA insert containing the protein D structural gene from a nontypeable Haemophilus influenzae strain (NTHi). An isogenic NTHi mutant was isolated after transformation of genetically competent bacteria. The transformant was unreactive to a protei

The HCl inner-valence photoelectron band at 26 eV binding energy has been recorded at high resolution. Discrete peaks arising from at least two separate vibrational progressions are superimposed on the broad continuum. Fano profiles are visible in one of the progressions. This indicates interference between superimposed electronic states, where weak avoided crossing allows two adiabatic states to

Conventionally, maximum capacities for energy assimilation are presented as daily averages. However, maximum daily energy intake is determined by the maximum metabolizable energy intake rate and the time available for assimilation of food energy Thrush nightingales (Luscinia luscinia) in migratory disposition were given limited food rations for 3 d to reduce their energy stores. Subsequently, grou

By using bootstrap technique we investigate the properties of the Breusch [Breusch, T.S., 1978. Testing for autocorrelation in dynamic linear models. Australian Economic Papers 17, 334-355]-Godfrey [Godfrey, L.G., 1978. Testing for higher order serial correlation in regression equations when the regressors include lagged dependent variables. Econometrica 46, 1303-1310] autocorrelation tests in dyn

1. It has recently been suggested that not only nutrients but also presence of a competitor can influence competitive ability in plants, for example, by strategic changes in allocation to roots (a 'tragedy of the commons' effect). Such strategic changes might occur also in pollen, because this has potential to increase siring success during pollen competition in the pistil. 2. I tested the new hyp

A double-blind, randomized, placebo-controlled cross-over multi-center study was conducted to evaluate the efficacy and safety of gabapentin in the treatment of neuropathic pain caused by traumatic or postsurgical peripheral nerve injury, using doses tip to 2400 mg/day. The study comprised a run-in period of two weeks, two treatment periods of five weeks separated by a three weeks' washout period.