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Exceptions and limitations (27 UPCA)

The UPCA for the first time establishes harmonized exceptions and limitations to the effects of granted patent rights. Previously these were the sole province of national law but a with a degree of similarity.This chapter briefly analyses the historical origin, legal nature and scope of Article 27 UPCA, the future harmonizing effect of UPCA patent limitations, followed by a discussion on each limi

Cell-Free DNA as a Biomarker in a Rodent Model of Chlorpyrifos Poisoning Causing Mitochondrial Dysfunction

Introduction: Organophosphates (OPs) are a major public health problem worldwide due to ease of access and high toxicity lacking effective biomarkers and treatment. Cholinergic agents such as OPs and carbamates are responsible for many pesticide-related deaths. While the inhibition of AChE is thought to be the main mechanism of injury, there are other important pathways that contribute to the over

Emulsifier adsorption kinetics influences drop deformation and breakup in turbulent emulsification

Turbulent drop breakup is of large importance for applications such as food and pharmaceutical processing, as well as of substantial fundamental scientific interest. Emulsification typically takes place in the presence of surface-active emulsifiers (natural occurring and/or added). Under equilibrium conditions, these lower the interfacial tension, enabling deformation and breakup. However, turbule

En observationsstudie av trafiken in och ut från operationssalen under pågående sterilt kirurgiskt ingrepp

Bakgrund: Tidigare studier har uppmärksammat bristande följsamhet till riktlinjer i operationssalen som i sin tur ökar risken för vårdrelaterade sårinfektioner. Att hålla nere antalet dörröppningar är en riktlinje där bristande följsamhet uppmärksammats i praktiken. Syfte: Syftet med studien var att observera och registrera trafiken in och ut från operationssalen under pågående sterilt kirurgiskt

Kärnvapen, inbördeskrig och en hemtrevlig känsla: Skapande och användande av minnen utifrån BioShock Infinite och Metro 2033

In light of video games and gaming becoming a more normalized and widespread phenomenon this essay examines how personal memories are created and used from playing video games. I have used the games BioShock Infinite and Metro 2033 as a basis for this discussion. The study is based on observations of internet forums centred around the games and live streams of people playing them. The theoretical

Measurement of ψ (2S) production as a function of charged-particle pseudorapidity density in pp collisions at √s = 13 TeV and p–Pb collisions at √sNN = 8.16 TeV with ALICE at the LHC

Production of inclusive charmonia in pp collisions at center-of-mass energy of s = 13 TeV and p–Pb collisions at center-of-mass energy per nucleon pair of sNN = 8.16 TeV is studied as a function of charged-particle pseudorapidity density with ALICE. Ground and excited charmonium states (J/ψ, ψ(2S)) are measured from their dimuon decays in the interval of rapidity in the center-of-mass frame 2.5 <

AKT1 induces Nanog promoter in a SUMOylation-dependent manner in different pluripotent contexts

AKT/PKB is a kinase crucial for pluripotency maintenance in pluripotent stem cells. Multiple post-translational modifications modulate its activity. We have previously demonstrated that AKT1 induces the expression of the pluripotency transcription factor Nanog in a SUMOylation-dependent manner in mouse embryonic stem cells. Here, we studied different cellular contexts and main candidates that coul

Release of prolactin as well as adrenocorticotropin after administration of arginine-vasopressin to healthy men

The study was undertaken to obtain simultaneous measurements of circulating anterior pituitary hormone levels after the i.v. injection of arginine-vasopressin (AVP). Nine healthy men, mean age 31 years (range 24-41), received single blind with at least one week apart, after resting in the supine position for 30 min, AVP 0.26 microgram/kg body weight i.v. (Pitressin, Parke-Davis) or saline in rando

Effect of acute desmopressin and of long-term thyroxine replacement on haemostasis in hypothyroidism

OBJECTIVE: Hypothyroidism can be complicated by bleeding symptoms such as easy bruising, menorrhagia and sometimes even a severe bleeding tendency with fatal outcome. Usually there is a prolonged bleeding time, or a low plasma concentration of coagulation factor VIII (FVIII) or von Willebrand factor (vWF). The aim of the present study was to investigate the acute haemostatic effect of desmopressin

Effects of adrenal function tests on the levels of endogenous digitalis-like substances and some pituitary hormones

In order to study the influence of the hypothalamic-pituitary-adrenal axis on the levels of endogenous digitalis-like substances (EDLS) in plasma and urine, eight healthy subjects (25-40 years old) were given dexamethasone 1 mg orally and tetracosactide (an ACTH analog) 0.25 mg i.v., on separate occasions. The circulating levels of EDLS, TSH, PRL and AVP following administration of either test dru

Jaktturism - avvägningar, utmaningar och möjligheter

Jaktturism anses ofta spela en viktig roll i hållbar landsbygdsutveckling. Turismenkan skapa arbeten, samt bidra till att traditioner och miljöer bevaras. En kommersiell jakt som riktar sig till lokala såväl som inresande jägare kan innebära att viltet kan användas som resurs på flera och nya sätt. När jakten ramas in och paketeras som turismprodukt, där boende, måltider och guidning ingår, kan ja

Personality, Positive Psychology and Evaluatively Neutralised Measurements

Examining the relationship between personality and positive psychology can when using a standard measure of personality produce spurious correlations, due to socially desirable responding (aka the evaluative factor). In this study Big Five measures of personality were related to the five most common measures of positive psychology. Using both an evaluative and an evaluatively neutralised measure o

Characterization of the internal working-life exposome using minimally and non-invasive sampling methods - a narrative review

During recent years, we are moving away from the ‘one exposure, one disease’-approach in occupational settings and towards a more comprehensive approach, taking into account the totality of exposures during a life course by using an exposome approach. Taking an exposome approach however is accompanied by many challenges, one of which, for example, relates to the collection of biological samples. M

The successful use of a search strategy improves with visuospatial working memory in 2- to 4.5-year-olds

Using spatial cues such as shape, orientation, and pattern aids visuospatial working memory because it allows strategies that reduce the load on this cognitive resource. One such strategy, namely taking advantage of patterned spatial distributions, remains understudied to date. This strategy demands keeping track of already-searched locations and excluding them from further search and so correlate

N2O–Assisted Siphon Foaming of Modified Galactoglucomannans With Cellulose Nanofibers

Foaming of most bio-based polymers is challenged by low pore formation and foam stability. At the same time, the developing utilization of bio-based materials for the circular economy is placing new demands for easily processable, low-density materials from renewable raw materials. In this work, we investigate cellulose nanofiber (CNF) foams in which foaming is facilitated with wood-based hemicell