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The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 commo

Quantitative measurements of acetylene (C2H2) molecules as a combustion intermediate species in a series of rich premixed C2H4/air flames were non-intrusively performed, spatially resolved, using mid-infrared polarization spectroscopy (IRPS), by probing its fundamental ro-vibrational transitions. The flat sooty C2H4/air premixed flames with different equivalence ratios varying from 1.25 to 2.50 we

In this paper we report the investigation of the laser-induced breakdown and ignition behaviour of methane/air and dimethyl ether (DME)/air mixtures. Moreover, the optical emission from the induced plasma is utilized for determining the mixture composition quantitatively by means of laser-induced breakdown spectroscopy (LIBS). To the best of the authors' knowledge, LIBS and laser ignition of DME h

Late cerebral ischaemia after subarachnoid haemorrhage (SAH) carries high morbidity and mortality because of reduced cerebral blood flow (CBF) and subsequent cerebral ischaemia. This is associated with upregulation of contractile receptors in cerebral artery smooth muscles via the activation of intracellular signalling. In addition, delayed cerebral ischaemia after SAH is associated with inflammat

This work focuses on the interaction of two coaxial swirling jets. High swirl burners are suitable for lean flames and produce low emissions. Computational Fluid Dynamics has been used to study the isothermal behaviour of two confined jets whose setup and operating conditions are those of the benchmark of Roback and Johnson. Numerical model is a Total Variation Diminishing and PISO is used to pres

Abstract in UndeterminedIn nineteenth-century Europe, the foundling hospital grew beyond its traditional purpose of mitigating the shame of unwed mothers by also permitting widows, widowers, and poor married couples to abandon their children there temporarily. In the Foundling Hospital of Madrid (fhm), this new short-term abandonment could be completely anonymous due to the implementation of a whe

Grafts of foetal ventral mesencephalon, used in cell replacement therapy for Parkinson's disease, are known to contain a mix of dopamine neuronal subtypes including the A9 neurons of the substantia nigra and the A10 neurons of the ventral tegmental area. However, the relative importance of these subtypes for functional repair of the brain affected by Parkinson's disease has not been studied thorou

Results from an experimental investigation of the phase behavior of an aqueous system of DNA from salmon testes and the protein lysozyme arc presented. At very low concentrations of either or both of the macromolecular components, wormlike assemblies with a width of the order of 10 nm are formed. There are strong indications that direct interactions between the protein units are instrumental both

Depression is the leading cause of disability worldwide and electroconvulsive therapy (ECT) is the most potent therapy. We investigated the clinical response and regional cerebral blood flow changes in depressed in patients treated with (ECT) in a repeated longitudinal study. Method: Forty-nine patients (21 men and 28 women) with a mean age 61 years underwent ECT. Forty-one patients grading improv

The lifetime risk for cardiovascular disease in a large cohort of childhood cancer survivors has not been fully assessed. In a retrospective population-based cohort study predicated on comprehensive national health registers, we identified a cohort of 32,308 one-year survivors of cancer diagnosed before the age of 20 in the five Nordic countries between the start of cancer registration in the 1940

Malarial infection is associated with complex immune and erythropoietic responses in the host. A quantitative understanding of these processes is essential to help inform malaria therapy and for the design of effective vaccines. In this study, we use a statistical model-fitting approach to investigate the immune and erythropoietic responses in Plasmodium chabaudi infections of mice. Three mouse ph

The use of supplemental oxygen in the setting of suspected acute myocardial infarction (AMI) is recommended in international treatment guidelines and established in prehospital and hospital clinical routine throughout the world. However, to date there is no conclusive evidence from adequately designed and powered trials supporting this practice. Existing data are conflicting and fail to clarify th

Background and Purpose: In this multicentre phase I-II trial we evaluated the feasibility and efficacy of capecitabine and oxaliplatin followed by the combination of these two drugs with radiotherapy in patients with locally advanced pancreatic or biliary tract cancer. Material and methods: Thirty-nine patients with inextirpable adenocarcinoma of the pancreas, gallbladder or extrahepatic bile duct

The major histocompatibility complex class II transactivator (CIITA) gene (16p13) has been reported to associate with susceptibility to multiple sclerosis, rheumatoid arthritis and myocardial infarction, recently also to celiac disease at genome-wide level. However, attempts to replicate association have been inconclusive. Previously, we have observed linkage to the CIITA region in Scandinavian ty

Atherosclerotic lesions are asymmetric focal thickenings of the intima of arteries that consist of lipids, various cell types and extracellular matrix (ECM). These lesions lead to vascular occlusion representing the most common cause of death in the Western world. The main cause of vascular occlusion is rupture of atheromatous lesions followed by thrombus formation. Fibronectin (FN) is one of the

Radiative interferences in the multi-parton shower is the building block of QCD jet physics in vacuum. The presence of a hot medium made of quarks and gluons is expected to alter this interference pattern. To study these effects, we derive the gluon emission spectrum off a color-correlated quark-antiquark pair (antenna) traversing a colored medium to first order in the medium density. The resultin

Environmental conditions and human activities play a significant role in structuring novel assemblages of native and non-native species. Ongoing and future climatic change may alter the performance of native and non-native species and their biotic interactions. In the northern hemisphere, expected climate changes include warmer temperatures and higher precipitation, the latter of which may increas

Objective To evaluate the influence of two ultra-low doses of oral continuous combined hormone therapy and placebo on metabolic parameters, and to assess safety endpoints and overall tolerability in healthy postmenopausal women. Design In a subpopulation of the Clinical study on Hormone dose Optimisation In Climacteric symptoms Evaluation (CHOICE) trial, lipids and parameters of glucose metabolism