Characterization of SLC40A1 in Acute Myeloid Leukemia by CRISPRi Gene Editing
Acute myeloid leukemia (AML) is characterized by an accumulation of immature blast cells, which outgrow the bone marrow and suppress normal blood formation. The condition is associated with poor survival, mainly caused by relapsed and refractory disease. Hence, new therapeutics are needed. Recently, SLC40A1 was identified as potentially important for AML cells in a pooled CRISPR interference scree