We present a versatile two color high-harmonic generation setup employing spatial light modulators for precise waveform control. Independent power control for both colors allows a continuous two-color ratio and phase scan of the harmonic yield.

Light-chain (LC) monoclonal gammopathy of undetermined significance (MGUS) is a precursor of multiple myeloma (MM) and related conditions. LC-MGUS is characterized by free light-chain (FLC) levels outside defined reference intervals, indirectly indicating underlying plasma cell (PC) monoclonality. Next-generation flow cytometry (NGF) was used to evaluate clonal PC presence in bone marrow (BM) samp

Hypercalcemia in monoclonal gammopathy of undetermined significance (MGUS) presents a clinical challenge since it may indicate progression to multiple myeloma (MM) but could also be due to a multitude of unrelated disorders. To inform the approach to this clinical challenge, we conducted a nested cohort study within the iStopMM screening study. Of the 75,422 Icelanders aged 40 years and above who

AIM: The study aimed to assess the haemodynamic effects of fludrocortisone and midodrine, alone or combined, in patients with recurrent syncope and/or symptoms due to hypotension and ≥ 1 daytime systolic blood pressure (SBP) drop < 90 mmHg or ≥ 2 daytime SBP drops < 100 mmHg recorded by 24-h ambulatory blood pressure monitoring (ABPM1).METHOD: A total of 53 patients (mean age, 40.9 ± 18.5 years, 3

Gestational diabetes mellitus (GDM) is a prevalent pregnancy complication that seriously endangers maternal and infant health, posing a medical and economic burden worldwide. Several dietary patterns have been recommended for women of childbearing age, demonstrating a positive role in preventing and managing GDM. However, these dietary patterns may not fully take environmental factors into account

Background: The TrialNet Oral Insulin (OI) prevention trial showed no overall treatment effect, using the diagnosis of type 1 diabetes as an endpoint. A significant delay in onset was only found in a high-risk stratum (termed secondary stratum 1) of participants with low first-phase insulin release (FPIR).Methods: Since trials with an endpoint of type 1 diabetes take years to complete, in this pos

Apidaecin 1b (Api), the first characterized Type II Proline-rich antimicrobial peptide (PrAMP), is encoded in the honey bee genome. It inhibits bacterial growth by binding in the nascent peptide exit tunnel of the ribosome after the release of the completed protein and trapping the release factors. By genome mining, we have identified 71 PrAMPs encoded in insect genomes as pre-pro-polyproteins. Ha

As a concept, agency stretches from philosophical and meta-theoretical elaborations to studies documenting largely idiosyncratic happenings in a particular empirical context, which could be dismissed as anecdotal. In between, and the source for the recent revival of scholarly interest, lies the promise to explain transformation processes, multiplex governance, and varieties in wellbeing and develo

Objectives Patients with type 2 diabetes mellitus (DM) run lower risk for abdominal aortic aneurysm (AAA, aortic diameter ≥ 30 mm) and its complications. We aimed to evaluate associations between disturbances in glucose metabolism and arterial stiffness, AAA, and abdominal aortic diameter in 65-year-old men. Methods Forty-eight 65-year-old men with screening-detected AAA and 115 men with normal ab

Abstract: The biliary excretion of the vasopressin analogue 1‐deamino‐8‐D‐arginine vasopressin (dDAVP) was determined in the pig after three administration routes, intrajugular venous, intraportal venous and intraduodenal. In all cases the biliary excretion was less than 1% of the administered dose. The plasma/bile concentration ratio was less than 1:1. A significant first‐pass effect was found wh

Background: While the energy system is recognized as the largest contributor to climate disruption, the bulk of the sustainability-oriented interventions are made through technologies rather than employment equity and social justice issues. Emergent research points to the critical role of increasing the number of women and other minoritized groups in the energy sector, which could have a cultural,

Background: Transcatheter aortic valve implantation (TAVI) has shown similar or improved clinical outcomes compared with surgical aortic valve replacement (SAVR) in patients with symptomatic severe aortic stenosis at low risk for surgical mortality. This cost-utility analysis compared TAVI with SAPIEN 3 versus SAVR in symptomatic severe aortic stenosis patients at low risk of surgical mortality fr

BACKGROUND: An unhealthy diet is a major contributor to several noncommunicable diseases, including cardiovascular diseases (CVD), the leading cause of death worldwide. Additionally, our food system has significant impacts on the environment. The EAT-Lancet Commission has recommended a healthy diet that preserves global environmental resources.OBJECTIVE: This prospective study evaluated the associ

Workplace incivility is a pervasive issue with implications for employee well-being. Drawing upon Self-Determination Theory, this study explores the association between experienced workplace incivility, need satisfaction, and work motivation and investigates whether workplace incivility is negatively associated with autonomous work motivation. We hypothesize that experiencing workplace incivility Workplace incivility is a pervasive issue with implications for employee well-being. Drawing upon Self-Determination Theory, this study explores the association between experienced workplace incivility, need satisfaction, and work motivation and investigates whether workplace incivility is negatively associated with autonomous work motivation. We hypothesize that experiencing workplace incivility

Objective: We investigated diagnostic utility of phosphorylated tau 217 and 181 (ptau217, ptau181), glial fibrillary acidic protein (GFAP), amyloid beta 42 and 40 (Aβ42, Aβ40), and neurofilament light (NfL) to distinguish biomarker-defined Alzheimer disease (AD) from non-AD conditions, in a heterogenous clinical cohort of younger people. Methods: Plasma biomarkers were analysed using ultrasensitiv

Background: Concizumab is an anti-tissue factor pathway inhibitor monoclonal antibody in development as a once-daily, subcutaneous prophylaxis for patients with haemophilia A or haemophilia B with or without inhibitors. We aimed to assess the efficacy and safety of concizumab in patients with haemophilia A or B without inhibitors. Here we report the results from the confirmatory analysis cutoff. M

We develop a cognitive evaluation schema for analysing the diversity and nuances of visuospatial complexity and multimodal interactions encountered in naturalistic everyday driving conditions. The proposed schema is based on a finegrained empirical analysis of real-world everyday driving situations involving stakeholders such as drivers, pedestrians, cyclists. Our method involves a semantic analys

Det svenska statsskicket omfattar en företeelse som brukar beskrivas som mer eller mindre unikt i världen: idén om att statliga förvaltningsmyndigheter ska vara självständiga i förhållande till regeringen. Mer precist brukar jurister tala om en självständighetsprincip som hänger ihop med vad som kallas ett förbud mot ministerstyre. Denna självständighetsprincip är uttryckligen reglerad i grundlag.