Background: It remains clinically important to identify ER positive breast cancers likely to respond to tamoxifen (TAM) and so we aimed to select a group of biomarkers able to predict response. We also assessed whether data from different sample types [tumor microarrays (TMAs) and core biopsies] or tumor sites could be combined for biomarker studies.Methods: A total of 123 endocrine treatment naïv

This study investigates values and narratives of urban biodiversity in the highly culturally and biologically diverse city Cape Town, South Africa. Local expressions of values of biodiversity are explored, in the context of the challenge of accounting for diverse values of biodiversity through a green infrastructure approach. Based on interviews with practitioners involved in green space and biodi

The world of work is facing an ongoing pandemic and an economic downturn with severe effects worldwide. Workers trapped in precarious employment (PE), both formal and informal, are among those most affected by the COVID-19 pandemic. Here we call attention to at least 5 critical ways that the consequences of the crisis among workers in PE will be felt globally: (a) PE will increase, (b) workers in

The present dissertation concerns how brain tissue properties reflect proficiency in two aspects of language use: the ability to use tonal cues on word stems to predict how words will end and the aptitude for learning foreign languages. While it is known that people differ in their language abilities and that damage to brain tissue cause loss of cognitive functions, it is largely unknown if differ

Background: Dizziness is common among patients with first time stroke. It affects self-perceived health and is a risk factor for falls. Vestibular rehabilitation (VR) is effective for treating dizziness among various conditions, but the effect of dizziness with origin in the central nervous system is poorly studied. This pilot study of a randomized controlled trial aimed at investigating a vestibu

INTRODUCTION: In Sweden, roughly 3000 patients are reoperated each year due to pain and loss of function related to a loosened hip or knee prosthesis. These reoperations are strenuous for the patient, technically demanding and costly for the healthcare system. Any such reoperation that can be prevented would be of great benefit. Bisphosphonates are drugs that inhibit osteoclast function. Several c

We show that the anticipation of COVID-19 vaccines reduces voluntary social distancing. In a large-scale preregistered survey experiment with a representative sample, we study whether providing information about the safety, effectiveness, and availability of COVID-19 vaccines affects compliance with public health guidelines. We find that vaccine information reduces peoples' voluntary social distan

We consider a market with indivisible objects, called houses, and monetary transfers. Each house is initially occupied by one agent and each agent demands exactly one house. The problem is to identify the complete set of direct allocation mechanisms that can be used to reallocate the houses among the agents. On the one hand, for price equilibrium mechanisms, we show that the only strategy-proof me

How can peace be climate resilient? How can peace and environmental sustainability be advanced simultaneously? To address these questions, I develop a new conceptual and theoretical framework for climate resilient peace through degrowth. This paper calls for stronger consideration of positive conceptualizations of peace and of intersectionality and degrowth in pursuit of peace and resilience. Not

This chapter examines the role that legal actors can play in promoting accountability for, and thereby potentially contributing to the reduction in the incidence of sexual assault in situations of disaster displacement, particularly in evacuation centres and temporary shelters. It argues that justice-sector actors can contribute to accountability for and a reduction in sexual assault in evacuation

OBJECTIVESTo characterize the phenotypic presentation at diagnosis of childhood-onset primary Sjögren syndrome (SjS).METHODSThe Big Data Sjögren Project Consortium is an international, multicentre registry using worldwide data-sharing cooperative merging of pre-existing clinical SjS databases from the five continents. For this study, we selected those patients in whom the disease was diagnosed bel

Under the Paris Agreement (PA), progress of emission reduction efforts is tracked on the basis of regular updates to national greenhouse gas (GHG) inventories, referred to as bottom-up estimates. However, only top-down atmospheric measurements can provide observation-based evidence of emission trends. Today, there is no internationally agreed, operational capacity to monitor anthropogenic GHG emis