The purification of crude (60.89% pure) paclitaxel was developed for high purity and yield. Several solvent systems, including methanol (MeOH), acetone, tetrahydrofurane, n-hexane, and water, were evaluated for precipitation efficiency. The best results were obtained using a mixture of MeOH and water, which was very effective at removing polar impurities, yielding a precipitate with 90.87% purity.

Background: Chronic obstructive pulmonary disease (COPD) is a severe condition affecting millions worldwide, leading to numerous annual deaths. The absence of significant symptoms in its early stages promotes high underdiagnosis rates for the affected people. Besides pulmonary function failure, another harmful problem of COPD is the systemic effects, e.g., heart failure or voice distortion. Howeve

Inosine triphosphatase (ITPA) is a ubiquitous key regulator of cellular non-canonical nucleotide levels. It breaks down inosine and xanthine nucleotides generated by deamination of purine bases. Its enzymatic action prevents accumulation of ITP and reduces the risk of incorporation of potentially mutagenic inosine nucleotides into nucleic acids. Here we describe the crystal structure of human ITPA

”Hemma drog jag upp dörren och skrek till mamma: ’Pappa är död.’ Efter det är minnet helt blankt” (s. 28). Den tolvårige Ingvar har hittat sin pappa liggandes bland säckarna i kafferosteriet där pappan arbetar. Fullständigt omskakande, både mänskligt och socioekonomiskt. Pojken Ingvar växer upp i ett typiskt arbetarhem i Borås. Pappa Olofs död innebär att mamma Ida får arbeta hårt med både jobb på

In clinical practice, the glomerular filtration rate (GFR), a measurement of kidney functioning, is normally calculated using equations, such as the European Kidney Function Consortium (EKFC) equation. Despite being the most general equation, EKFC, just like previously proposed approaches, can still struggle to achieve satisfactory performance, limiting its clinical applicability. As a possible so

Grass pollen allergens, including Phl p 5 from Phleum pratense, are major triggers of seasonal allergic rhinitis, primarily mediated by IgE antibodies. This study investigates the genetic basis and functional characteristics of IgG1 antibodies targeting Phl p 5, possibly derived from type 2 memory B cells predisposed to IgE switching. Using site-directed mutagenesis, we analyzed variants of a high

BackgroundGender-based violence (GBV) is an internationally widespread human rights and public health issue, known to be exacerbated and underreported in humanitarian settings and among conflict-affected populations. A combination of factors including increased vulnerability, lack of protection and marginalization are believed to increase the risk for GBV in settings such as displacement and refug

This thesis investigates the ignition and flame spread behaviour of engineered wood-based materials, focusing on Medium-Density Fibreboard (MDF), Particleboard, Oriented Strand Board (OSB), and Plywood. Thermal properties, such as thermal conductivity and specific heat capacity, were analysed using Transient Plane Source (TPS) measurements. A new technique has been introduced for measuring thermal

Objectives: Subarachnoid haemorrhage (SAH) carries a high burden of morbidity and mortality. One in three patients develop vasospasm, which is associated with Delayed Cerebral Ischemia. The pathophysiology includes vasoconstrictor receptor upregulation in cerebral arteries. The protein kinase C – inhibitor RO-31-7549 reduces the expression of several vasoconstrictor receptors and normalizes cerebr

Background: Intervention trials that have demonstrated significant effects may not always replicate those effects when scaled up. This study aimed to test whether scaling-up a successful cluster randomized trial (the COMMUNICATE study, 9 intervention communities), which promoted population-level physical activity (PA), could promote PA in a broader citywide setting (29 communities) after two years

Accurately simulating stomatal behavior is crucial for understanding water, carbon, and energy fluxes between land and atmosphere. Given the significant impact of plastic film mulching on water and temperature, it is essential to incorporate water and temperature modifications into stomatal conductance models under these conditions. In this study, we evaluated three commonly used stomatal conducta

In x-ray photoelectron spectroscopy (XPS), identifying the origin of peaks in the spectrum can be guided by theory calculations. With density functional theory (DFT), using pseudopotentials, one can obtain the difference in photoelectron energy for electrons originating from atoms of different environments, for example surface and bulk atoms, and thus model the surface core level shift (SCLS) ener

This paper discusses the role of different factors determining the linguistic competence of heritage speakers (HSs) based on examples from speakers who speak a Romance language (French, Italian, Portuguese, or Spanish) as heritage language (HL) and German as the environmental language. Since the relative amount of contact with the HL and the environmental language may vary during the acquisition p

Objective: Determine participants’ satisfaction with rehabilitation following total laryngectomy (TL) and investigate associations between dysphagia, voice problems, and possible explanatory variables. Methods: 172 Danish and Swedish participants having received a TL 1.6–18.1 years ago for laryngeal/hypopharyngeal cancer answered a questionnaire regarding satisfaction with rehabilitation following

The pursuit of high charge carrier mobility in nanostructures is crucial for advancing both device development and exploring fundamental physics. This study focuses on minimizing scattering to achieve high mobility, employing a polytype type-II interface formed between wurtzite and zincblende InP. On the zincblende side, electrons accumulate, while holes gather on the wurtzite side, resulting in t

Soil health in Europe has reached a critical point: it is estimated that 60-70% of European soils are unhealthy. Changes in land use, its intensity and the quality of management have significant impacts on soil health and soil related ecosystem services. A systems analysis of soil health dynamics requires an understanding of the drivers inducing changes in land use and management. The DPSIR framew

Immune thrombocytopenia (ITP) is an autoimmune disease characterized by an isolated thrombocytopenia and variable phenotype as some patients suffer no bleeding whilst others have bleeding from mild to severe, which may be fatal. This variability probably reflects the disease's complex pathophysiology; a dysregulated hyperreactive immune effector cell response involving the entire adaptive immune s