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Single Nucleotide Polymorphisms in Close Proximity to the Fibroblast Growth Factor 21 (FGF21) Gene Found to Be Associated with Sugar Intake in a Swedish Population

Hereditary mechanisms are partially responsible for individual differences in sensitivity to and the preference for sweet taste. The primary aim of this study was to examine the associations between 10 genetic variants and the intake of total sugar, added sugar, and sugars with sweet taste (i.e., monosaccharides and sucrose) in a middle-aged Swedish population. Two single nucleotide polymorphisms

Comparison of organ absorbed doses in whole-body computed tomography scans of paediatric and adult patient models estimated by different methods

This study aimed to identify the uncertainty in estimations of organ absorbed dose using dedicated software by comparing with corresponding doses measured in physical phantoms. The comparison was performed for whole-body computed tomography (CT) obtained as part of positron emission tomography. Whole-body CT scans provide an advantage in terms of comparison because all organs are in the primary be

X-Ray and molecular imaging during pregnancy and breastfeeding - When should we be worried?

Some of the ethically most sensitive issues in radiation protection arise at imaging of pregnant - and potentially pregnant - patients and of newborn. This article reviews the current literature and recommendations on imaging during pregnancy and breastfeeding. Risks related to alternative non-ionizing radiation methods are also considered. With few exceptions, exposure of the fetus through radiog

Development of two-photon polymerised scaffolds for optical interrogation and neurite guidance of human iPSC-derived cortical neuronal networks

Recent progress in the field of human induced pluripotent stem cells (iPSCs) has led to the efficient production of human neuronal cell models for in vitro study. This has the potential to enable the understanding of live human cellular and network function which is otherwise not possible. However, a major challenge is the generation of reproducible neural networks together with the ability to int

Quantification of pulmonary pathology in cystic fibrosis-comparison between digital chest tomosynthesis and computed tomography

Purpose: Digital tomosynthesis (DTS) is currently undergoing validation for potential clinical implications. The aim of this study was to investigate the potential for DTS as a low-dose alternative to computed tomography (CT) in imaging of pulmonary pathology in patients with cystic fibrosis (CF). Methods: DTS and CT were performed as part of the routine triannual follow-up in 31 CF patients. Exte

The Study of Security Priming on Avoidant Attentional Biases : Combining Microsaccadic Eye-Movement Measurement With a Dot-Probe Task

Microsaccades are small fixational eye movements that have shown to index covert attentional shifts. The present experiment combined microsaccades with performance measures from a dot-probe task to study influences of attachment security priming on the attentional biases of individuals high in attachment avoidance. Security priming is an experimental manipulation aimed at boosting felt security. U

The Influence of Level of Education on Instrumental Activities of Daily Living in Patients with Alzheimer’s Disease.

Background: According to the “brain-reserve hypothesis” in Alzheimer’s disease (AD), patients with more years of education are expected to have higher cognitive status during adulthood. Hence, they might have a relatively larger burden of AD pathology and a more advanced level of the disease when dementia is clinically evident. Higher educated people would also be expected to perform better on sta

Testing the psychometric properties of the Swedish version of the EPOCH measure of adolescent well-being

The EPOCH Measure of Adolescent Well-being measures five positive indicators of the well-being of adolescents: engagement, perseverance, optimism, connectedness and happiness. This five-factor structure along with other indicators of validity and reliability were supported for the original English version and the Chinese version. In this study, we tested the psychometric properties of the Swedish

Management and Information Technology after Digital Transformation

With the widespread transformation of information into digital form through-out society - firms and organisations are embracing this development to adopt multiple types of IT to increase internal efficiency and to achieve external visi-bility and effectiveness - we have now reached a position where there is data in abundance and the challenge is to manage and make use of it fully. This book addres

The 5-year-olds' index, the GOSLON Yardstick index, and the modified Huddart/Bodenham index among children with complete unilateral cleft lip and palate : A methodological study

Background: The function of many orthodontic indices is to assess occlusion in patients born with a cleft. The aim of this study was to assess the intra- and interexaminer reliability for the 5-year-olds' (5YO) index, the GOSLON Yardstick index, and the modified Huddart/Bodenham (MHB) index in dental casts of children with complete unilateral cleft lip and palate (UCLP); a further aim is to compar

Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction : What Do We Know?

Post-acute sequelae of SARS-CoV-2 (PASC), or long COVID syndrome, is emerging as a major health issue in patients with previous SARS-CoV-2 infection. Symptoms commonly experienced by patients include fatigue, palpitations, chest pain, dyspnea, reduced exercise tolerance, and "brain fog". Additionally, symptoms of orthostatic intolerance and syncope suggest the involvement of the autonomic nervous

Multi-proxy record of Holocene paleoenvironmental conditions from Yellowstone Lake, Wyoming, USA

A composite 11.82 m-long (9876–67 cal yr BP) sediment record from Yellowstone Lake, Wyoming was analyzed using a robust set of biological and geochemical proxies to investigate the paleoenvironmental evolution of the lake and its catchment in response to long-term climate forcing. Oxygen isotopes from diatom frustules were analyzed to reconstruct Holocene climate changes, and pollen, charcoal, dia

Deglacial Ventilation Changes in the Deep Southwest Pacific

Processes underlying changes in the oceanic carbon storage during the Last Glacial Maximum and the subsequent deglaciation are not fully understood. Here, we present a new high-resolution radiocarbon reconstruction (expressed as δ14R) at the depth of the modern Lower Circumpolar Deep Water from the Pacific Sector of the Southern Ocean. Our record shows δ14R increases during Heinrich Stadial 1 and

A collective alternative to the Inward Turn in environmental sustainability research

It has become quite common in environmental sustainability research to promote the influencing of so-called inner dimensions of individuals as means to address pressing environmental problems such as climate change, what we refer to as the Inward Turn. We argue that the conceptual foundations of the Inward Turn, an extreme form of methodological individualism, limit it significantly as a strategy

Thickness and composition of native oxides and near-surface regions of Ni superalloys

The surface chemistry and thickness of the native oxide, hydroxide, and modified sub-surface layer of three Ni superalloys (alloy 59, 625, and 718) were determined by synchrotron X-ray Photoelectron Spectroscopy (XPS) and X-ray Reflectivity (XRR). Taking advantage of the synchrotron radiation techniques, a procedure for normalizing the photoelectron intensity was employed, which allowed for accura

Beam-based characterization of higher-order-mode driven coupled-bunch instabilities in a fourth-generation storage ring

Longitudinal coupled-bunch instabilities are driven by monopole higher-order modes (HOMs) in the active and passive radio-frequency (rf) cavities at the MAX IV 3 GeV electron storage ring. By combining different beam and rf-based techniques, we have performed a systematic survey of the properties of these resonant modes as a function of cavity temperatures and fundamental mode frequency. This info

Implementing an intermittent spin-coating strategy to enable bottom-up crystallization in layered halide perovskites

Two-dimensional halide perovskites (2D PVSKs) have drawn tremendous attentions owing to their outstanding ambient stability. However, the random orientation of layered crystals severely impedes the out-of-plane carrier transport and limits the solar cell performance. An in-depth understanding coupled with an effective control of the crystallization in 2D PVSKs is the crux for highly efficient and