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Piperacillin/tazobactam versus carbapenems for 30-day mortality in patients with ESBL-producing Enterobacterales bloodstream infections: a retrospective, multicenter, non-inferiority, cohort study

PurposeAntimicrobial resistance increases with the use of broad-spectrum antibiotics. Studies evaluating antibiotic stewardship are in high demand. Is piperacillin/tazobactam non-inferior to carbapenems regarding 30-day mortality among patients with bloodstream infections caused by extended-spectrum beta-lactamase-producing Enterobacterales?MethodsThis retrospective, multicenter, non-inferiority,

Optimizing industrial etching processes for PCB manufacturing : real-time temperature control using VGG-based transfer learning

Accurate temperature control in Printed Circuit Board (PCB) manufacturing is essential for maintaining high-quality etching results. Automated monitoring us-ing machine vision and deep learning offers an effective approach for this task. This study investigated a feature-based transfer learning technique for classifying temperature readiness in infrared images of the etching process. The captured

Small Books with a Mission : Prayer Books as Tools of Re-Catholicisation, c. 1540–1590

This thesis examines the role of German-language Catholic prayer books in the re-Catholicisation of Protestants during the approximate timeline 1540–1590. Within the broader context of the Catholic Reformation, these prayer books served as instruments of doctrinal transmission and devotional instruction, representing a form of ‘soft’ re-Catholicisation in contrast to the coercive methods used by s

Cellular and molecular cartography of muscle-invasive bladder cancer: Who benefits from neoadjuvant chemotherapy?

Muscle-invasive bladder cancer (MIBC) is characterised by significant molecular heterogeneity, with the tumour composition being further sculptured by local microenvironmental influences. This inherent complexity contributes to the divergent disease trajectories and the variable therapeutic susceptibility observed among patients. Consequently, there is an evident need for prognostic and predictive

KGB with a human face? End of illusions. : Social protests of Soviet workers in Novocherkassk 1962 as an initiator of a change in the character of the KGB

This article analyses the role of the Soviet political police and the KGB state security in suppressing large workers' protests in Novocherkassk in 1962. The aim is not only to study the actions of the KGB during the crisis itself, but above all to show how the events in Novocherkassk contributed to the subsequent change in the overall character of this repressive service and, more generally, the

Rights-based climate litigation with children as protagonists : a critical review of the literature

The last couple of years’ child/youth-led climate cases like Juliana v. US, Sacchi et al. v. Argentina et al. and the Duarte Agostinho case at the European Court of Human Rights have sparked the beginnings of a new sub-field of socio-legal child rights studies. The present paper systematically and critically reviews this emerging body of literature on rights-based climate litigation with children

Status of Sepsis Care in European Hospitals Results from an International Cross-Sectional Survey

Rationale: Early detection, standardized therapy, adequate infrastructure, and strategies for quality improvement should constitute essential components of every hospital’s sepsis plan. Objectives: To investigate the extent to which recommendations from the sepsis guidelines are implemented and the availability of infrastructure for the care of patients with sepsis in acute-care hospitals. Methods

Evaluation of the adsorptive behaviour of kraft black liquor on nanofiltration model membrane surfaces via quartz crystal microbalance with dissipation monitoring (QCM-D)

Membrane filtration of kraft black liquor (KBL), a side-stream of the pulp and paper industry, is challenged by membrane fouling caused by its multicomponent complexity. The specific contributions of the components found in KBL to the fouling and the characteristics of the fouling layer that they create has not been investigated. Herein, the adsorptive and desorptive behaviours of KBL ultrafiltrat

Paleolithic Diet in Type 2 Diabetes : Effects on glycaemic control when body weight is kept stable and on leptin

Background: Previous studies indicate comparably greater improvement in glycaemic control from Paleolithic diet, possibly due to an accompanying greater reduction in body weight, which, in turn, could be due to an accompanying greater reduction in leptin.Aims: To assess in type 2 diabetes the effect of Paleolithic diet on glycaemic control when body weight is kept stable and diets matched for macr

Global Transcriptional Complexity of Estrogen Receptor Low Positive Breast Cancers in a Prospective Swedish Population-based SCAN-B Cohort

PURPOSE: There is uncertainty whether ER-low tumors with a 1-10% immunohistochemical staining of nuclei represent a distinct molecular biological entity of BC, posing significant challenges for their clinical management and developing novel therapies. We aimed to elucidate ER-low tumor biology.EXPERIMENTAL DESIGN: We analyzed primary tumors included in a Swedish population-based SCAN-B BC cohort,

Simulation of friction and wear for a low-steel brake material based on experimental pv-mapping of its basic constituents

The coefficient of friction (COF) and wear are critical parameters in assessing disc brake performance. However, their study is challenging due to their interdependence on contact pressure, sliding velocity, temperature, and material composition. The complex contact interactions between brake pads and discs involve the continuous formation and destruction of mesoscopic contact plateaus, which

Non–β-hemolytic Streptococcal Bacteremia in Patients With Heart Valve Prosthesis—Is It Always Infective Endocarditis?

IntroductionNon-beta-haemolytic streptococci are among the most common causative agents of infective endocarditis (IE). Patients with a heart valve prosthesis (HVP) have a high risk of IE. We aimed to determine the risk for IE in patients with HVP and non-beta-haemolytic streptococcal bacteraemia (NBHSB), and to study NBHSB relapse depending on treatment duration.MethodAdults with HVP and NBHSB 20