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Phospholipase C-mediated hydrolysis of phosphatidylinositol 4,5-bisphosphate generates diacylglycerol, inositol 1,4,5-trisphosphate and protons, all of which can regulate TRPV1 activity via different mechanisms. Here we explored the possibility that the diacylglycerol metabolites 2-arachidonoylglycerol and 1-arachidonoylglycerol, and not metabolites of these monoacylglycerols, activate TRPV1 and c
A CMOS oscillator employing differential transistor pairs working in Class-C in push-pull configuration is presented. The oscillator exhibits the same advantages enjoyed by complementary topologies on oscillators based on a single differential pair, while yielding a substantial power consumption reduction thanks to the Class-C operation. The phase-noise performance and the fundamental conditions r
In the Uppåkra house the place for a possible high seat dedicated to the woman is marked out by a deposit consisting of a bronze beaker with embossed gold-foil bands and a glass bowl originated from the area around the Black Sea. These objects acted as props in the drinking ceremonies and social activities involving gift giving carried out by the queen or the lady of the house. The exclusive natur
Waldenstrom's macroglobulinemia (WM) is associated with a precursor condition, monoclonal gammopathy of undetermined significance (MGUS) of immunoglobulin-M (IgM) type. The etiology of these conditions is unknown. Recent studies at the population level have provided new data regarding familial aggregation of these disorders and other B-cell malignancies. Studies of familial clusters of WM have dem
Three- and four-jet production is measured in deep-inelastic ep scattering at low x and Q(2) with the H1 detector using an integrated luminosity of 44.2 pb(-1). Several phase space regions are selected for the three-jet analysis in order to study the underlying parton dynamics from global topologies to the more restrictive regions of forward jets close to the proton direction. The measurements of
The aim was to investigate whether there are any positive consequences of childhood cancer. Studies published 1990-2005 reporting survivors' descriptions of positive consequences of childhood cancer were identified through a search in the databases CINAHL, PsycINFO, and PubMed. According to a manifest content analysis, positive consequences were referred to three themes: life values, relations to
We have developed a self-aligned L-g = 55 nm In-0.53 Ga-0.47 As MOSFET incorporating metal-organic chemical vapor deposition regrown n(++) In0.6Ga0.4As source and drain regions, which enables a record low on-resistance of 199 Omega mu m. The regrowth process includes an InP support layer, which is later removed selectively to the n(++) contact layer. This process forms a high-frequency compatible
The ability to invent means to deceive others, where the deception lies in the perceptually or contextually detached future, appears to require the coordination of sophisticated cognitive skills toward a single goal. Meanwhile innovation for a current situation has been observed in a wide range of species. Planning, on the one hand, and the social cognition required for deception on the other, hav
Enligt socialtjänstlagen ska äldreomsorgen vara individanpassad och ges utifrån den enskildes behov. Samma lag innehåller ett mål om att socialtjänsten ska främja medborgarnas jämlikhet i levnadsvillkor och kommunallagen anger att kommunen ska behandla sina invånare lika. I denna artikel problematiseras idéer om individanpassning och likvärdig behandling. Dessa olika målsättningar skapar spänninga
Abstract in UndeterminedEnterprise resource planning (ERP) systems are rapidly becoming a de facto standard in business activity. While large and medium-sized companies have the luxury to afford proprietary ERP solutions, small companies are struggling with resource poverty which maybe makes them consider available open source ERP products which are free from licensing fee. However, there is littl
This paper addresses selection between two calculation options, i.e heat loss option and mass loss option, for thermal manikin measurements on clothing evaporative resistance conducted in an isothermal condition (Tmanikin = Ta = Tr). Five vocational clothing ensembles with a thermal insulation range of 1.05–2.58 clo were selected and measured on a sweating thermal manikin ‘Tore’. The reasons why t
Biomedicine is typically defined as the branch of medicine that is based on the principles of biology and biochemistry. A central tenet for biomedicine is the notion of disease and therapeutic specificity, i.e. the idea of tailored treatments for discrete disorders underpinned by specific pathologies. The present paper is concerned with how notions of disease and therapeutic specificity guide biom
Male breast cancer (MBC) is extremely rare and poorly characterized on the molecular level. Using high-resolution genomic data, we aimed to characterize MBC by genomic imbalances and to compare it with female breast cancer (FBC), and further to investigate whether the genomic profiles hold any prognostic information. Fifty-six fresh frozen MBC tumors were analyzed using high-resolution tiling BAC
Background: Intense physical activity (PA) improves muscle strength in children, but it remains uncertain whether moderately intense PA in a population-based cohort of children confers these benefits. Methods: We included children aged 6-9 years in four schools where the intervention school increased the school curriculum of PA from 60 minutes/week to 40 minutes/school day while the control school
Patients with Type 2 diabetes and coronary heart disease (CHD) are infrequently treated to risk factor targets in current guidelines. We aimed to examine risk factor management and control levels in a large sample of patients with Type 2 diabetes with CHD. This was an observational study of 1612 patients with first incidence of CHD before 2002, and of 4570 patients with first incidence of CHD befo
We study a decomposition problem for a class of unitary representations associated with wavelet analysis, wavelet representations, but our framework is wider and has applications to multi-scale expansions arising in dynamical systems theory for non-invertible endomorphisms. Our main results offer a direct integral decomposition for the general wavelet representation, and we solve a question posed
Many children and adolescents with hearing impairment struggle to meet school demands. The difficulties can be traced to the characteristics of the hearing impairment, and to adverse consequences on language development, often overlooked in diagnostics and intervention. This thesis investigates the communicative ability of children and adolescents with bilateral sensorineural hearing impairment by
