Phosphorylation of 6‐chloropurine riboside with phosphorus oxychloride and phosphorus trichloride gave a mixture of the two isomers, 6‐chloropurine‐riboside 2′,5′‐bisphosphate and 6‐chloropurine‐riboside 3′,5′‐bisphosphate. Reaction with 1,6‐diaminohexane followed by resolution of the isomeric mixture on a Dowex 1‐X2 column yielded N6‐(6‐aminohexyl)‐adenosine 2′,5′‐bisphosphate and N6‐(6‐amin

Alkylation of NAD+ with iodoacetic acid followed by alkaline rearrangement gave N6-carboxymethyl-NAD+. Condensation of this analogue with 1,6-diaminohexane gave the analogue NAD+- N6-[N-(6-aminohexyl)-acetamide]. The coenzymic activity of the two derivatives was tested with malate dehydrogenase, alcohol dehydrogenase and lactate dehydrogenase. The efficiency relative to unsubstituted NAD+ was i

To a Sepharose gel the pyridine nucleotide NAD(H) has been bound using dicyclohexyl carbodiimide. In order to improve the steric availability of the nucleotide for added soluble enzymes such as dehydrogenases, a spacer molecule, ε-amino caproic acid, was inserted between the carbohydrate matrix and the nucleotide. The obtained preparation contained 56 μmoles NAD+/g dry polymer. The obtained

Superporous particles contain two sets of pores, normal diffusion pores and very large flow pores. If such particles are used chromatographically, part of the flow will pass through each particle. This leads to a rapid equilibration between the stationary and the mobile phases, even if the superporous particle has a large outer diameter. Superporous particles are thus chromatographically efficient

Long-term screening with serum prostate-specific antigen (PSA) and systematic prostate biopsies can reduce prostate cancer mortality but leads to unacceptable overdiagnosis. Over the past decade, diagnostic methods have improved and the indolent nature of low-grade prostate cancer has been established. These advances now enable more selective detection of potentially lethal prostate cancer. This n

This thematic issue of the Journal of Digital History focuses on different digital tools that are used to study, explore, and narrate the past. Our idea has been to collect a broad range of articles that demonstrate and critique new ways of exploring the past through computational means—all in order to open up and problematize the use of digital methods in historical research, including analytical

Mortar extrusion during bricklaying, resulting from suboptimal workmanship, may act as a bridge linking clay brick masonry claddings and adjacent layers (e.g., insulation or weather-resistant barriers), thereby, facilitating water penetration into the adjacent layer owing to wind-driven rain (WDR). Despite the significant effect of water penetration on the hygrothermal performance of building enve

This study presents a state-of-the-art review of the evolution of probabilistic hygrothermal assessments of building envelopes. First, relevant literature was identified by employing a systematic methodology, including scoping and systematic searches, quality assessment, and study analysis. The analysis, based on 143 selected publications, provides statistical insights into uncertainty propagation

Fungal cells from Curvularia lunata were entrapped in a crosslinked polyacrylamide gel. The gel-cells obtained as granules were applied in the microbial transformation of Reichstein compound S leading to cortisol through an 11-β-hydroxylation step. Some kinetic studies of this conversion using gel-cells were carried out. In addition, it was shown that gel-cell granules which had lost part o

Influencers befinner sig i epicentrum av digitalisering och motstridiga arbetsideal. En industrikapitalistisk idealisering av (manligt) lönearbete dröjer sig kvar, men utmanas av en nyliberal (postfeministisk) tilltro till individens (inte minst kvinnans) drivkraft att som entreprenör styra livet mot framgång och lycka. Här undersöks hur tolv kvinnliga mikro-influencers förhåller sig till könade nThe feminine-coded work as an influencer has emerged as young women have transformed their personal life stories and self- representations on social media into digital businesses. Despite similarities with other forms of media production, the concept of work is vague, both in the public’s perception of what influencers do and for influencers themselves. It is challenging to differentiate between w

Den här artikeln ger ett exempel på hur medelålders kvinnor återupptäcker och uttrycker känslor i digitala medier, främst sexuell åtrå men också den glädje de känner bland likasinnade kvinnor i samma ålder. Det etnografiska exemplet är en grupp europeiska och nordamerikanska kvinnor i åldrarna 40-60 år som känner sexuell åtrå till den 20-årige TikTok-kändisen William White. White blev viral när haThis article provides an example of how middle-aged women rediscover and express emotions in digital media, mainly sexual desire but also the joy they feel among like-minded women of the same age. The ethnographic case is a community of European and North American women aged around 40 to 60 years who sexually desire 20-year-old TikTok celebrity William White. White went viral when he began lip-syn

Poddcast "Öppet fall" från Lunds universitet, Juridiska fakulteten: Ett gift par som inte kan få egna barn beger sig till en fertilitetsklinik för att göra en provrörsbefruktning. Kvinnan vill sätta in två ägg men mannen går bara med på ett ägg. Trots det säger hon till kliniken att sätta in två ägg och blir gravid med tvillingar. Mannen accepterar inte att bli pappa till barnen eftersom han inte