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Human neural stem cells: region-specific properties and prospects for cell therapy

Popular Abstract in Swedish Stroke är en sjukdom som främst drabbar äldre och är den största anledningen till att människor får olika slags handikapp såsom förlamning och afasi. Det finns ännu ingen effektiv behandling för att lindra symtom och lidande efter en stroke, förutom rehabilitering, och därför kostar stroke samhället enormt mycket pengar. Befolkningen blir allt äldre, vilket även medför Cell replacement by neural transplantation can, in animal models of neurodegenerative diseases, reconstruct damaged brain circuitry. In the clinical situation, the graft material used for cell therapy must, most likely, be of human origin. The human fetal brain is one potential source of neural stem cells (NSCs) for cell replacement therapy in neurodegenerative disorders such as stroke. Stroke is

MetCap: a bioinformatics probe design pipeline for large-scale targeted metagenomics

Background: Massive sequencing of genes from different environments has evolved metagenomics as central to enhancing the understanding of the wide diversity of micro-organisms and their roles in driving ecological processes. Reduced cost and high throughput sequencing has made large-scale projects achievable to a wider group of researchers, though complete metagenome sequencing is still a daunting

Struggling to survive for the sake of the unborn baby: a grounded theory model of exposure to intimate partner violence during pregnancy

Background: Intimate partner violence (IPV) during pregnancy is a serious matter which threatens maternal and fetal health. The aim of this study was to develop a grounded theoretical model of women's experience of IPV during pregnancy and how they handle their situation. Method: Ten interviews with women who had experience of being exposed to IPV during pregnancy were analyzed using the grounded

Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome.

Glutamic acid decarboxylase 65 (GAD65) and autoantibodies specific for GAD65 (GADA) are associated with autoimmune diseases including Stiff Person Syndrome (SPS) and Type 1 diabetes (T1D). GADA is recognized as a biomarker of value for clinical diagnosis and prognostication in these diseases. Nonetheless, it remains medically interesting to develop sensitive and specific assays to detect GAD65 pre

Human complement activation by smooth and rough Proteus mirabilis lipopolysaccharides

Proteus mirabilis bacilli play an important role in human urinary tract infections, bacteremia, and rheumatoid arthritis. The authors previously studied human complement C3 conversion by smooth-form P. mirabilis O10, O23, O30, and O43 lipopolysaccharides (LPSs) and showed that smooth Proteus LPSs fragmented C3 in a dose- and time-dependent manner. In the present study, one smooth P. mirabilis S195

Swirl sign in intracerebral haemorrhage: definition, prevalence, reliability and prognostic value

Background: Swirl sign has previously been described in epidural hematomas as areas of low attenuation, radiolucency or irregular density. The aims of this study were to describe swirl sign in ICH, study its prevalence, study the reliability of the subjective evaluation on computed tomography (CT), and to explore its prognostic value. Methods: CTs of 203 patients with ICH were retrospectively eval

Arkeologi och identitet

In this book several authors from the Nordic countries discuss the concept of identity as used within archaeology. Identity is as well part of the cultural heritage as an active component in today's political discussion. Ranging from present uses of identity today to the use of identity in the past, the 17 articles in the book show how identity works within archaeology.

Signatures of Wigner localization in epitaxially grown nanowires

It was predicted by Wigner in 1934 that an electron gas will undergo a transition to a crystallized state when its density is very low. Whereas significant progress has been made toward the detection of electronic Wigner states, their clear and direct experimental verification still remains a challenge. Here we address signatures of Wigner molecule formation in the transport properties of InSb nan

General-purpose event generators for LHC physics

We review the physics basis, main features and use of general-purpose Monte Carlo event generators for the simulation of proton-proton collisions at the Large Hadron Collider. Topics included are: the generation of hard scattering matrix elements for processes of interest, at both leading and next-to-leading QCD perturbative order; their matching to approximate treatments of higher orders based on

Laser pulse propagation and enhanced energy coupling to fast electrons in dense plasma gradients

Laser energy absorption to fast electrons during the interaction of an ultra-intense (10(20) Wcm(-2)), picosecond laser pulse with a solid is investigated, experimentally and numerically, as a function of the plasma density scale length at the irradiated surface. It is shown that there is an optimum density gradient for efficient energy coupling to electrons and that this arises due to strong self

Safety and efficacy of drug-eluting vs. bare metal stents in patients with diabetes mellitus: long-term follow-up in the Swedish Coronary Angiography and Angioplasty Registry (SCAAR)

Patients with diabetes mellitus have more extensive coronary artery disease, more disease progression, and restenosis. The use of drug-eluting stents (DES) in these patients is widespread, despite uncertain long-term safety and efficacy. All consecutive patients with diabetes mellitus in Sweden who underwent percutaneous coronary intervention were entered into the Swedish Coronary Angiography and

Frequency-dependent echolocation beam pattern of the bottlenose dolphin.

Moore and others (2008) previously showed that bottlenose dolphins are capable of beam steering and controlling the vertical and horizontal widths of the echolocation beam. A follow-on study was performed using the same methods as the previous study, but with a younger animal and a higher resolution diamond-shaped hydrophone array for characterizing the beam. The dolphin performed a target detecti

Two-dimensional elastic contact model for rubber covered rollers

A model for the contact between a rubber covered roller and a rigid roller was developed using analytical functions. The model, being two-dimensional, connects the line load, geometric properties (roller radii, rubber thickness) and the shear modulus of the rubber to nip properties in the roller contact. The output from the model is the indentation of the rigid roller into the rubber, the nip maxi

Three-dimensional ultrasound studies of normal and abnormal ovaries

Popular Abstract in Swedish Äggstockarna genomgår förändringar under en normal menstruationscykel. I samband med tumörväxt i äggstockarna utvecklas nya blodkärl. Dessa förändringar kan upptäckas med både tvådimensionellt (2D) och tredimensionellt (3D) gråskale- och Doppler-ultraljud. Med Doppler-ultraljud kan man upptäcka blodkärl och uppskatta blodflödeshastigheterna i blodkärlen. Referensvärden The aims of this work were: 1) to estimate the number of follicles, ovarian volume and power Doppler vascular indices and their changes with age using three-dimensional (3D) transvaginal grey-scale and power Doppler ultrasound in asymptomatic women of fertile age either with natural menstrual cycles or using combined oral contraceptives, and 2) to determine whether tumour vascularity, assessed by

Global transcriptional analysis of pheromone biosynthesis-related genes in the female turnip moth, Agrotis segetum (Noctuidae) using a custom-made cDNA microarray.

Using a custom-made cDNA microarray, global transcriptional analyses were conducted to identify genes differentially regulated in the pheromone gland as compared to the remaining insect tissue of the moth Agrotis segetum (Noctuidae). A two-fold or larger difference in relative expression levels was found for 227 of 864 genes investigated comparing the two tissues. Unexpectedly, an antennal binding

A. EUF-fördraget

Rättsfallskommentar avseende 2012 års domar från EU-domstolens som rör medlemsstaternas inkomstskatteregler

Conodont biostratigraphy, taxonomy and palaeoecology in the Darriwilian (Middle Ordovician) of Baltoscandia - with focus on meteorite and extraterrestrial chromite-rich strata

Popular Abstract in Swedish Conodonter är en numera utdöd grupp havslevande djur vars systematiska ställning länge varit föremål för debatt. De var i det längsta kända enbart genom sina millimeterstora, kalciumfosfatiska element, vilka vi idag vet satt i djurens munhåla. Sådana conodontelement beskrevs för första gången 1856 av Christian Heinrich Pander, men det skulle dröja närmare 130 år innan dThis thesis deals with conodont biostratigraphy and palaeoecology in the Darriwilian (Middle Ordovician) of Baltoscandia, with focus on limestone strata showing traces of the ~ 470 Ma L-chondrite parent body break-up. The evidence for this cosmic event includes abundant centimeter to decimeter-sized fossil meteorites and elevated levels of sediment-dispersed extraterrestrial L-type chromite found

Juxtarenal aortic aneurysm - Endovascular treatment and imaging techniques

Treatment of abdominal aortic aneurysms has shifted rapidly from open surgery to minimally invasive endovascular aneurysm repair (EVAR). However, anatomical limitations such as short or absent proximal sealing neck and poor access vessels exclude up to 50% of patients. In attempt to increase the number of patients suitable for EVAR, fenestrated devices have emerged. In this new era, precise and re