Genome-wide association studies have recently identified at least 15 susceptibility loci for systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from 2,466 regions that showed nominal evidence of association to SLE (P < 0.05) in a genome-wide study and genotyped them in an independent sample of 1,963 cases and 4,329 controls. This replication effort identified fiv

MicroRNAs have emerged as important regulators of smooth muscle phenotype and may play important roles in pathogenesis of various smooth muscle related disease states. The aim of this study was to investigate the role of miRNAs for urinary bladder function. We used an inducible and smooth muscle specific Dicer knockout (KO) mouse which resulted in significantly reduced levels of miRNAs, including

Biophysical models that describe the outcome of white matter diffusion MRI experiments have various degrees of complexity. While the simplest models assume equal-sized and parallel axons, more elaborate ones may include distributions of axon diameters and axonal orientation dispersions. These microstructural features can be inferred from diffusion-weighted signal attenuation curves by solving an i

In this paper, we present a controller synthesis algorithm for a decentralized control problem. We consider an architecture in which there are two interconnected linear subsystems. Both controllers seek to optimize a global quadratic cost, despite having access to different subsets of the available measurements. Many special cases of this problem have previously been solved, most notably the state

In a recent paper Pedroni and Yao (2006) present strong evidence suggesting that Chinese provincial per-capita output is diverging, a result that goes against the Chinese government’s goal of a balanced wealth-creation across provinces. This paper provides an in-depth analysis of the reasoning behind this finding. Our main result is that the divergence does exist, even when new data and more advan

The increase of total choline in tumors has become an important biomarker in cancer diagnosis. Choline and choline metabolites can be measured in vivo and in vitro using multinuclear MRS. Recent in vivo C-13 MRS studies using labeled substrates enhanced via dynamic nuclear polarization demonstrated the tremendous potential of hyperpolarization for real-time metabolic studies. The present study dem

Results are presented of searches for the production of supersymmetric particles decaying into final states with missing transverse momentum and exactly two isolated leptons in root s = 7 TeV proton-proton collisions at the Large Hadron Collider. Search strategies requiring lepton pairs with identical-sign or opposite-sign electric charges are described. In a data sample corresponding to an integr

Reaction of [Ru(CO)(9){mu(3-)eta(1),kappa(1),kappa(2)-PhP(C6H4)CH2PPh}] (1) with tri(2-thienyl) phosphine (PTh3) in refluxing THF afforded [Ru-3(CO)(9)(PTh3)(mu-dpbm)] (3){dpbm = PhP(C6H4)(CH2)PPh} and [Ru-3(CO)(6)(mu-CO)(2){mu-kappa(1),eta(1)-PTh2(C4H2S)}{mu(3)-kappa(1),ka ppa(2)-Ph2PCH2PPh}] (5) in 18% and 12% yields, respectively, while a similar reaction with tri(2-furyl)phosphine (PFu(3)) gav

In this thesis, human behavior in rail tunnel fires is explored. Descriptive knowledge is presented related to the evacuation of passenger trains, and the subsequent tunnel evacuation to a safe location. More specifically, a theoretical framework that can aid the understanding of human behavior is identified, and its applicability to rail tunnels is demonstrated. In addition, new empirical data on

Chondroadherin, a leucine rich repeat extracellular matrix protein with functions in cell to matrix interactions, binds cells via their α2β1 integrin as well as via cell surface proteoglycans, providing for different sets of signals to the cell. Additionally, the protein acts as an anchor to the matrix by binding tightly to collagens type I and II as well as type VI. We generated mice with inactiv

This essay discusses the author Sara Stridsberg's revisiting of Valerie Solana's work and anger as a feminist response to the injustice of sexism and homophobia and to envision a future loaded with feminist energy.

Accidental falls in the elderly are a major health problem, despite extensive research on risk factors and prevention. Only a limited number of multifactorial, long-term prospective studies have been performed on risk factors for falls in the general elderly population. The aim of this study was to identify risk factors predicting falls in a general elderly population after three and six years, us

Background: Research suggests that the growing prevalence of obesity may be related to the influence of the health behaviours of peers. We look at clustering of exercise and eating behaviours amongst a previously unstudied group, young adults in Sweden. Previous research has mainly been conducted in the United States and Britain, countries that have relatively high rates of obesity. Methods: Using

Lubricants are used in numerous applications in our society, for instance, as hydraulic fluids. When used in forestry, 60-80% of these hydraulic fluids are released into the environment. This is one of the reasons for the growing interest for developing and utilising hydraulic fluids with good environmental performance. Another driving force in the development of hydraulic fluids is to replace fos

The response of a matrix of 25 lead tungstate (PWO) scintillator detectors, operated at -25 degrees C, to photons in the range 13 MeV-64 MeV has been measured at the tagged-photon facility at MAX-lab, Lund. The tapered PWO crystals, each with a length of 200 mm and a cross-section of 24.4 x 24.4 mm(2) in the front end, read out by 19 mm photomultiplier tubes, were arranged in a 5 x 5 matrix. The r