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Increased particle flow rate from airways precedes clinical signs of ARDS in a porcine model of LPS-induced acute lung injury

Acute respiratory distress syndrome (ARDS) is a common cause of death in the intensive care unit, with mortality rates of ~30-40%. To reduce invasive diagnostics such as bronchoalveolar lavage and time-consuming in-hospital transports for imaging diagnostics, we hypothesized that particle flow rate (PFR) pattern from the airways could be an early detection method and contribute to improving diagno

The Nordic doctorate at a crossroads between Bildung, schoolification and projectification

The Nordic doctorate has its roots in the Germanic Bildung-tradition, with a decentralised and discipline-oriented curriculum, local and individualised leadership and autonomous supervisors. Currently, the Nordic doctorate has arrived at a crossroads where it is pulled in two different directions. The first characterised by formalisation and centralised Graduate Schools with study directors, middl

Advancing gene therapy for epilepsy. Translational pre-clinical studies with neuropeptide Y and glial cell-line derived neurotrophic factor.

Epilepsy is a neurological disorder, affecting approximately 1% of the population. The high rate of drug-resistance in epilepsy in general (30%), and temporal lobe epilepsy (TLE) in particular, pose a serious clinical problem. Thus, novel treatments for drug-resistant epilepsy is highly warranted. Gene therapy has been suggested to be a promising approach to target drug-resistant focal epilepsy si

Climate and vegetation dynamics of the Northern Apennines (Italy) during the Late Pleistocene and Holocene

This study reconstructs the regional vegetation and climate dynamics between the upper Late Pleistoceneand Holocene around Pian del Lago, a coastal mountain marshland located at 831 m asl in westernLiguria (NW-Italy), based on the pollen analysis of a 13 m-long sediment core. The record provided aunique opportunity to study a poorly documented period in northern Italy and across many parts ofsouth

Duration of load behaviour of a glued shear plate dowel joint

An experimental study on the duration of load effects in a glued shear plate dowel joint was conducted. The joint design features a single large diameter dowel for load transfers between members, via external steel plates, which are bonded to the timber with a low stiffness bond line. Due to the low bond line stiffness, the timber element is subjected to a close to uniform shear stress distributio

Frequently Recurrent Takotsubo Syndrome in COPD

Cardiovascular disease is common among patients with chronic obstructive pulmonary disease (COPD). Takotsubo syndrome (TTS) is a transient cardiac disorder that, in its typical form, involves left ventricular dysfunction with apical ballooning and mimics acute coronary syndrome (ACS). "Bronchogenic TTS" has been proposed as a specific form of TTS (during severe acute dyspnea in asthma or COPD) witCardiovascular disease is common among patients with chronic obstructive pulmonary disease (COPD). Takotsubo syndrome (TTS) is a transient cardiac disorder that, in its typical form, involves left ventricular dysfunction with apical ballooning and mimics acute coronary syndrome (ACS). "Bronchogenic TTS" has been proposed as a specific form of TTS (during severe acute dyspnea in asthma or COPD) wit

Herkogamy, a principal functional trait of plant reproductive biology

Premise of research. Phenotypic traits that consistently mediate species’ responses to environmental variation (functional traits) provide a promising approach toward generalizing ecological and evolutionary patterns and thereby gaining insights into the processes generating them. In the plant functional ecology literature, most trait-based studies have focused on traits mediating either resource

Rendering local: The politics of differential knowledge in carbon offset governance

Environmental governance relies on the translation of socioecological knowledge across disciplines and cultural–political boundaries. Comparatively few studies have, however, examined how such expert knowledge is translated back into the local contexts where projects are implemented. This article explores these processes of translation for the case of forest-based carbon offsetting using a case st

Sflash - First results of direct seeding at flash

The free-electron laser facility FLASH at DESY (Hamburg) was upgraded during a five month shutdown in winter 2009 [1]. Part of this upgrade was the installation of a direct seeding experiment in the XUV spectral range. Besides all components for transport and diagnostics of the photon beam into and out of the accelerator environment, a new 10m long variable-gap undulator was installed upstream of

Photon diagnostics for the seeding experiment at FLASH

Starting from next year the technical feasibility of a direct seeding scheme at 30 and 13 nm will be studied at the Free-electron LASer in Hamburg (FLASH). During a major shutdown the SASE-FEL facility will be upgraded and it is planned to install in addition a high-harmonic generation (HHG) seed laser, a new chain of 10 m variable gap un-dulators and a dedicated commissioning beamline for photon

The saturated regime of a seeded single-pass free electron laser : A theoretical investigation through the statistical mechanics of the Vlasov equation

The quasi-stationary state characterizing the saturation of a single-pass free-electron laser is governed by the Vlasov equation obtained by performing the continuum limit of the Colson-Bonifacio model. By means of a statistical treatment, this approach allows to predict analytically the saturated laser intensity as well as the final electron-beam energy distribution. In this paper we consider the

Coherent harmonic emission of the elettra storage ring free electron laser in single pass configuration : A numerical study for different undulator polarizations

The optical klystron installed on the Elettra storage-ring is normally used as interaction region for an oscillator free-electron laser, but, removing the optical cavity and using an external seed laser, one obtains an effective scheme for single-pass harmonic generation. In this configuration the high-power external laser is synchronized with the electron beam entering the first undulator of the

Free electron laser study of free carbon clusters

UV absorption from carbon nanoparticles is a very interesting astrophysical topic. The prominent hump centred at 217.5 nm is the most dominant feature in the interstellar extinction curve and also the most controversial and a long-standing problem in astrophysics. At the University of Milano an experimental set-up based on a Pulsed Microplasma Cluster Source has been developed for the investigatio

Q-switch techniques implemented at the Elettra storage-ring free-electron laser

In a Storage-Ring Free-Electron Laser (SRFEL) giant pulses can be produced by the interaction between the light stored in the optical cavity and an electron beam with low energy-spread (cold beam). This interplay produces the heating of the beam. After the generation of a single giant pulse the overlap between electrons and radiation is periodically prevented for a time necessary to dump the energ