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Vascular endothelin type B receptor upregulation correlates with activation of inflammatory transcriptional factor NF-kappaB
Arabinosylated phenolics obtained from SO2-steam-pretreated sugarcane bagasse
A pentose-rich hydrolysate fraction obtained by extraction of steam-pretreated sugarcane bagasse was analysed with regard to dissolved phenolics. The liquid obtained after steam pretreatment (2% SO2 (w/w) at 190 ◦C for 5min)was divided into two parts: one containing dissolved compounds originating from hemicellulose (with xylose as the dominating compound), and the other containing predominantly d
The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness.
FLT3 and c-KIT are crucial regulators of hematopoietic stem and progenitor cells. We investigated the role of STS1 and STS2 on FLT3 and c-KIT phosphorylation, activity, and function in normal and stress-induced hematopoiesis. STS1/STS2-deficient mice show a profound expansion of multipotent progenitor and lymphoid primed multipotent progenitor cells with elevated colony-forming capacity. Although
Laser Remote Sensing for Environmental Monitoring
Popular Abstract in Swedish Sedan den industriella revolutionen har världen konfronterats med många miljöproblem, t.ex. luftföroreningar, surt regn, global uppvärmning, farligt avfall, ozonhålsproblematik, ”smog” och vattenföroreningar. Det är viktigt att utveckla mätteknik för att objektivt kunna fastställa miljöförhållandena för att sedan kunna göra adekvata åtgärder. Miljön kan direkt karakteriThis thesis studies the techniques of laser remote sensing and their applications in environmental monitoring, as documented in several published papers. The environment where the human being live is degrading with an accelerating speed. Quantitative monitoring characterizes the quality of the environment and offers possibilities to solve environmental problems. Laser remote sensing actively prob
Empirically derived psychosocial states among adolescents diagnosed with cancer during the acute and extended phase of survival
Patients and methods: Participants completed the Hospital Anxiety and Depression Scale and two subscales, Vitality and Mental Health, in the SF-36 4-8 weeks (T1) (n = 61), 6 (T2) (n = 57), 12 (T3) (n = 50), and 18 (T4) months (n = 48) after diagnosis. I-State as Object of Analysis was used to identify a finite set of states based on three dimensions. Cluster analysis was carried out using Ward's m
Side-effects of post-treatment biopsies in prostate cancer patients treated with endocrine therapy alone or combined with radical radiotherapy in the Scandinavian Prostate Cancer Group-7 randomized trial
Objective. Post-treatment prostate biopsy side-effects were evaluated in patients with locally advanced prostate cancer on endocrine therapy alone or combined with radiotherapy in the Scandinavian Prostate Cancer Group-7 randomized trial. Material and methods. One-hundred and twenty patients underwent transrectalultrasound-guided biopsy, and were requested to complete a questionnaire on side-effec
Tackling Hypoxia in the Baltic Sea: Is Engineering a Solution?
Visual education. Film and video activities in Sweden during World War II
Polytraumatization in an adult national sample and its association with psychological distress and self-esteem
Objective: The objective of this study was to examine the prevalence of selfreported experiences of potential childhood traumas and polytraumatization, and to find cut-off values for different kinds of potential traumatic events in a national representative sample of adults in Sweden. In addition, to analyse the association between polytraumatization and both psychological distress and global self
Gradience in analysis: a cse of presentative passive
Non-alcoholic Steatohepatitis Induces a Decrease in the Levels of S-100b in the Rat Brain
Using an experimental model of non-alcoholic (alimentary-induced) steatohepatitis in rats, we found that this pathological condition created by consumption of a special diet for 16 weeks results in a drop in the brain mass (by 22%, on average) and also in decreases in the size and morphological modifications of astrocytes and the level of a calcium-binding protein, S-100b. The latter shifts were g
A Scientific Revolution that Made Life Longer. Schooling and the Decline of Infant Mortality in Europe
This paper addresses the decline in infant mortality that occurred with a remarkable synchronization across Europe around the turn of the century 1900. It is the argument of this paper that this development is not just, as in the conventional view, the side effect of economic growth but could be derived through a cumulative chain of events, starting with the discovery of the germ theory. Mokyr has
Geographical Differences in Autoantibodies and Anti-infectious Agents Antibodies Among Healthy Adults
Much is known about the geoepidemiology of defined autoimmune diseases (AD); however, there is currently limited data regarding the prevalence of autoantibodies among healthy populations of different geographical areas. The aim of this study was to evaluate a large profile of autoantibodies in healthy adults from distinct global regions as well as the prevalence of anti-infectious agents antibodie
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The social return on investment in community befriending
Purpose: This paper illustrates the social and economic impact of services delivered by a small charity to families affected by post-natal depression (PND). It highlights challenges and offers insights to the meaning of ‘value for money’ for commissioners of public health services. Design/methodology/approach: The analysis is based on a social return on investment (SROI) approach. Evidence was g
Model-Based Optimization of Economical Grade Changes for the Borealis Borstar Polyethylene Plant
Economical grade changes are considered for a Borealis Borstar polyethylene plant model, incorporating two slurry-phase reactors, one gas-phase reactor and a recycle area with three distillation columns. The model is constructed in the Modelica language and the JModelica.org platform is used for opti- mization. The cost function expresses the economical profit during a grade change and is formulat
Low 8-oxo-7,8-dihydro-2'-deoxyguanosine levels and influence of genetic background in an Andean population exposed to high levels of arsenic.
BACKGROUND: Arsenic (As) causes oxidative stress through generation of reactive oxygen species. 8-Oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), a sensitive marker of oxidative DNA damage, has been associated with As exposure in some studies, but not in others, possibly due to population-specific genetic factors. OBJECTIVES: To evaluate the association between As and 8-oxodG in urine in a population
Breast feeding, but not use of oral contraceptives, is associated with a reduced risk of rheumatoid arthritis
Objective: To determine whether breast feeding or the use of oral contraceptives (OCs) affects the future risk of rheumatoid arthritis ( RA) in a community-based prospective cohort. Methods: A community-based health survey (18 326 women) was linked to regional and national registers, and incident cases of RA were identified. All women with a diagnosis of RA after inclusion in the health survey (n
Comparison of ultrasonography with Doppler and MRI for assessment of disease activity in juvenile idiopathic arthritis: a pilot study
Background: In juvenile idiopathic arthritis (JIA), the trend towards early therapeutic intervention and the development of new highly effective treatments have increased the need for sensitive and specific imaging. Numerous studies have demonstrated the important role of MRI and US in adult rheumatology. However, investigations of imaging in JIA are rare, and no previous study has been comparing