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Background: Previous studies have indicated that there may be a difference in tumor biology between intraductal papillary mucinous carcinoma (IPMC) and pancreatic ductal adenocarcinoma (PDAC). However, the data are still controversial. The aim of this systematic review and meta-analysis was to summarize and compare the outcome of IPMC and PDAC after surgical resection. Methods: Studies comparing I

Over 840 M ha of arable land is affected by salinization, and the area is predicted to increase due to global change. Assessments of the status of the microbial community in saline soils have frequently been based on microbial biomass estimates, which might not accurately reflect microbial process rates in soil. Moreover, assessments of how the relative importance of major decomposer groups bacter

Export of warm and salty waters from the Caribbean to the North Atlantic is an essential component of the Atlantic Meridional Overturning Circulation (AMOC). However, there was also an active AMOC during the Miocene, despite evidence for an open Central American Seaway (CAS) that would have allowed low-salinity Pacific waters to enter the Caribbean. To address this apparent contradiction and to co

Trade-offs exist among the multiple ecosystem services (ES) generated by forests. Generally, wood production conflicts with the provisioning of public-good ES such as the storage of carbon, nutrient retention and conservation of biodiversity. Recognizing that forests generate both private- and public-good ES implies that forestry should be optimized to maximize the contribution of forests to socie

Natural wetlands constitute the largest and most uncertain source of methane (CH4) to the atmosphere and a large fraction of them are found in the northern latitudes. These emissions are typically estimated using process ("bottom-up") or inversion ("top-down") models. However, estimates from these two types of models are not independent of each other since the top-down estimates usually rely on th

Air travel is often justified as ‘necessary’ or ‘unavoidable’, in the sense that trips have purpose and value. Yet it is evident that people travel for reasons that may include forced and voluntary movement, with motives ranging from visiting friends and family, to leisure, or business. In light of the challenge to decarbonise transport, and the need to reduce greenhouse gas emissions, this paper

Regional Student Groups (RSGs) of the International Society for Computational Biology Student Council (ISCB-SC) have been instrumental to connect computational biologists globally and to create more awareness about bioinformatics education. This article highlights the initiatives carried out by the RSGs both nationally and internationally to strengthen the present and future of the bioinformatics

The distributions of migratory species in the ocean span local, national and international jurisdictions. Across these ecologically interconnected regions, migratory marine species interact with anthropogenic stressors throughout their lives. Migratory connectivity, the geographical linking of individuals and populations throughout their migratory cycles, influences how spatial and temporal dynami

Antibodies are an essential part of the human immune system, and antibody mediated immunity has been an area of interest for many researchers for almost a century. An accumulation of knowledge regarding antibody structure, glycosylation and receptor interactions has contributed to the current understanding of antibody mediated immunity. It has more recently become evident how bacteria and other mi

Thyroid hormones transiently increase during parr-smolt transformation in coho salmon, Oncorhynchus kisutch, and are believed to trigger morphological, physiological, behavioural, and neural changes. The effectiveness of propylthiouracil (PTU) to induce hypothyroidism in smolting coho salmon was determined by immersing coho salmon, Oncorhynchus kisutch, in 30 mg 1-1 PTU from May 1, two weeks prior

Free plasma thyroxine (FT4) levels were measured in coho salmon, Oncorhynchus kisutch, during parr-smolt transformation (smoltification) using an equilibrium dialysis system followed by a radioimmunoassay. The FT4 data were correlated to total plasma thyroxine (TT4), triiodothyronine (TT3), and growth hormone (GH). Plasma samples were taken weekly from early April to late May, when the salmon wher

1. During early ontogeny, the serotonergic neurons in the brain stem of the three-spined stickleback shows a temporal and spatial developmental pattern that closely resembles that of amniotes. 2. However, in the adult fish, only the midline nuclei of the rostral group (dorsal and median raphe nuclei) and the dorsal lateral tegmental nucleus are consistently serotonin-immunoreactive (5-HTir), where

The organization of the serotonergic cell groups in the brainstem of fishes and amphibians has received relatively little attention. It has been generally assumed that they are little differentiated and constitute a median cell column throughout the brainstem, and that laterally migrated serotonergic cell groups are largely lacking. In the present study we present evidence to the contrary. By the

The inhibitory neurotransmitter γ-aminobutyric acid (GABA) is known to exert various neurotrophic actions in the developing nervous system, but little is known about its distribution in the central nervous system during early development. We have studied the development of GABA-immunoreactive (GABAir) neurons during embryogenesis of a teleost fish, the three-spined stickleback. As early as 51 h po

The ontogenetic development of serotoninergic neurons in the brain of the stickleback was investigated with the indirect immunocytochemical peroxidase-antiperoxidase technique, using a specific antibody to serotonin (5-hydroxytryptamine, 5-HT). Formation of neuronal populations takes place during embryonic development. By 80 h after fertilization, the first 5-HT perikarya have appeared in the vent

In the coho salmon there is a transient increase in total brain concentrations of serotonin during smolt transformation which occurs midlife, just before down-stream migration to the ocean. There is also a gradual age-related increase in total brain serotonin concentrations. These increases may be due to reorganization of the central serotonergic system, changes in serotonin turnover, or both. The

The development of catecholaminergic neuronal systems in the brain of a teleost, the three-spined stickleback, was studied through embryonic to early larval stages by immunocytochemistry using specific antibodies against dopamine, tyrosine hydroxylase and dopamine β-hydroxylase. By analysing the spatiotemporal patterns of development for the catecholaminergic nuclei, possible homologies with nucle

Antisera against a variety of substances have been found to produce an identical immunoreaction in the developing olfactory system of a teleost, the three-spined stickleback (Gasterosteus aculeatus). The label is localized in the olfactory placode, the olfactory nerve and those parts of the secondary olfactory tracts which constitute the dorsal descending fascicles and the ventral descending fiber

The expression of the engrailed homeobox gene during trout embryogenesis has been examined using immunohistochemistry and the monoclonal antibody 'Mab 4D9'. Engrailed has been suggested to play an important role during development by controlling position-specific characteristics in the CNS of the early embryo. In the present study we have analyzed the expression of engrailed at 5 stages of embryon