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L-DOPA-induced dyskinesia (LID) in Parkinson's disease has been linked to altered dopamine and glutamate transmission within the basal ganglia. In the present study, we compared compounds targeting specific subtypes of glutamate receptors or calcium channels for their ability to attenuate LID and the associated activation of striatal nuclear signalling and gene expression in the rat. Rats with 6-h

We present analysis and preliminary laboratory testing of a real-time dual-conjugate adaptive optics (DCAO) instrument for ophthalmology that will enable wide-field high resolution imaging of the retina in vivo. The setup comprises five retinal guide stars (GS) and two deformable mirrors (DM), one conjugate to the pupil and one conjugate to a plane close to the retina. The DCAO instrument has a cl

Dilution of flames using recirculated exhaust gas or water vapor is an important NOx reduction technique in various combustion applications. Dilution, however, can also lead to combustion instabilities due to reduced burning velocities. For methanol/air flames this subject is largely unexplored. Therefore, the current work examines the effects of diluting methanol/air flames with nitrogen and wate

Popular Abstract in Swedish Hjärt och kärlsjukdomar utgör idag den vanligaste orsaken till död världen över. I denna avhandling studerades patienter med hjärt-kärlsjukdom inom svenska register för att analysera betydelsen av olika komponenter av behandlingen vid hjärt-kärlsjukdom. Komponenter som utvärderades var tid till primär perkutan (endovaskulär) kranskärlsintervention (PCI), dvs ballongvidgIntroduction: Ischemic heart disease is the leading cause of death worldwide. The aims of this thesis were to evaluate different contemporary approaches in coronary care with regard to mortality and myocardial infarction. Methods: The thesis consists of 6 papers with 4 papers evaluating different exposures and their outcomes (clopidogrel pre-treatment, 5 different anti-platelet protocols, ticagrel

A previous investigation of all 10 TLR-genes for associations with allergic rhinitis (AR) detected a number of significant SNPs in the TLR8 locus. The associations indicated that an accumulation of rare variants could explain the signal. The present study therefore searches for rare variants in the TLR8 region and also investigates the reproducibility of previous SNP associations.

A pollen record obtained from a 2.2-m sediment succession deposited in a small lake in the province of Vasterbotten, north-eastern Sweden, reveals the presence of continuous forest cover since 8,500 calendar years before present (cal B.P.). Forest with abundant Pinus (pine) and Betula (birch) initially colonized the area, followed by a dominance of deciduous trees, primarily Betula, from ca. 8,000

AIMS: Liver is a target organ in many mitochondrial disorders, especially if the complex III assembly factor BCS1L is mutated. To reveal disease mechanism due to such mutations, we have produced a transgenic mouse model with c.232A>G mutation in Bcs1l, the causative mutation for GRACILE syndrome. The homozygous mice develop mitochondrial hepatopathy with steatosis and fibrosis after weaning. Our a

Här behandlas Sveriges förbindelser med andra politisk-territoriella enheter, frånmedeltidens dynastiska unioner över de tidigmoderna konglomeratstaterna till1800-talets union av två nationalstater. Med hjälp av befintlig forskning fokuserasstatens växlande sammansättning och vikten av att skilja mellan riket och staten.Ett sådant perspektiv visar nya aspekter och ställer frågor som ett traditioneDuring most of the period from 1319 to 1905, the kingdom of Sweden formed part of a larger state, either through union with other states or through the possession of provinces that were not part of the kingdom proper. This is a neglected theme in Swedish historiography, where Sweden is described as a trans-historical entity, sometimes larger and sometimes smaller than the present state but still b

In Sweden, as in many other European countries, government and public agencies have promoted the expansion of eHealth over the past years, arguing that this development enhances patient participation, empowerment and cost efficiency. This paper presents a longitudinal study of the deployment of My medical records on the Internet, a civic service originally inspired by the home banking concept. The

Ferrochelatase catalyzes the metallation of protoporphyrin IX in the terminal step of heme biosynthesis. Mutations in the ferrochelatase gene can lead to the disease erythropoietic porphyria. The catalyzing mechanism of ferrochelatase is still not fully understood. In this paper, we have studied the insertion of Fe2+ into the protoporphyrin IX ring by Bacillus subtilis ferrochelatase using combine

This article presents a new tool for automatic design of application-specific reconfigurable processor extensions based on UPaK (Abstract Unified Patterns Based Synthesis Kernel for Hardware and Software Systems). We introduce a complete design flow that identifies new instructions, selects specific instructions and schedules a considered application on the newly created reconfigurable architectur

This thesis consists of three essays on VIX futures and options, and deals with issues highly relevant to all financial markets, such as understanding the operation of markets and developing flexible and tractable pricing models for contracts traded in them. It consists of four chapters. Chapter 1 provides a short introduction to the VIX and a brief explanation of how the old and new VIX are cons

Although it is well known that the dynamic properties of rubber depend on both frequency and amplitude, there are few commercially available finite element codes that take account of these effects. This paper outlines a simplified procedure to extend the usability of the commercially available frequency dependent viscoelastic finite element models to also take account of the amplitude dependence.

The polymeric immunoglobulin receptor (PIGR) has been proposed to be a candidate prognostic biomarker in a few cancer forms, and one previous study reported that reduced PIGR expression signifies more aggressive tumours of the distal esophagus and gastroesophageal junction (GEJ). In the present study, we examined the expression, clinicopathological correlates and prognostic significance of PIGR ex

The reduction of the (A root 5x root 5)R27 degrees surface oxide on Pd(100) and Pd75Ag25(100) surfaces by CO has been investigated by high-resolution X-ray photoelectron spectroscopy in combination with kinetic analysis using the Avrami-Erofeev theory. For both surfaces we observed faster reduction with increasing temperature. Kinetic analysis indicates that the reduction process is phase boundary

The design of bioinspired nanostructures and materials of defined size and shape is challenging as it pushes our understanding of biomolecular assembly to its limits. In such endeavors, DNA is the current building block of choice because of its predictable and programmable self-assembly. The use of peptide- and protein-based systems, however, has potential advantages due to their more-varied chemi

Abstract in UndeterminedResearch on social capital routinely relies on survey measures of trust which can be collected in large and heterogeneous samples at low cost. We validate such survey measures in an incentivized public good experiment and show that they are importantly related to cooperation behavior in a large and heterogeneous sample. We provide evidence on the microfoundation of this rel

The phytohormone auxin plays an essential role in many aspects of plant growth and development. Its patterning, intercellular transport, and means of signaling have been extensively studied both in experiments and computational models. Here, we present a review of models of auxin-regulated development in different plant tissues. This includes models of organ initiation in the shoot apical meristem

2009 avsatte Lunds universitet 1,5 miljoner SEK att användas till att betala publiceringsavgifter i Open Access tidskrifter. Pengarna administreras av Biblioteksdirektionen. Fonden har främst använts till medlemskap i tre OA-förlag, BioMed Central, PLoS och Hindawi. Medlemskapen i BMC och PLoS innebär att Biblioteksdirektionen betalar publiceringsavgifterna centralt för artiklar där ”corresponding