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Influence of the upstream slot geometry on the endwall cooling and phantom cooling of vane suction side surface

Modern gas turbines always operate at a high level of inlet temperature. The current inlet temperature in the aircraft and heavy duty gas turbines is higher than the melting point of the guide vane material. Consequently, advanced cooling schemes must be developed to ensure the safe operation of gas turbines. In the current study, numerical simulations were conducted to investigate the influence o

Fetal hemoglobin in umbilical cord blood in preeclamptic and normotensive pregnancies : A cross-sectional comparative study

Preeclampsia (PE) is associated with increased fetal hemoglobin (HbF) in the maternal circulation but its source is unknown. To investigate whether excessive HbF is produced in the placenta or the fetus, the concentration of HbF (cHbF) in the arterial and venous umbilical cord blood (UCB) was compared in 15825 normotensive and 444 PE pregnancies. The effect of fetal gender on cHbF was also evaluat

Structural and functional brain alterations in a murine model of Angiotensin II-induced hypertension

Hypertension is a main risk factor for the development of cerebral small vessel disease (cSVD) – a major contributor to stroke and the most common cause of vascular dementia. Despite the increasing socioeconomic importance arising from cSVD, currently only a few specific treatment strategies with proven efficacy are known. Fundamental to the lack of specific treatments is poor understanding of the

Proliferation of human lens epithelial cells (HLE-B3) is inhibited by blocking of voltage-gated calcium channels

Calcium, as an integral part of a large number of cellular regulatory pathways, is selective in the control of specific cell functions like the start of G1 phase in cell cycle. Cell proliferation has been suggested to depend on increasing intracellular calcium levels. A major regulatory pathway for intracellular calcium is the calcium influx into the cell via voltage-gated calcium channels. T-type

Leukemia inhibitory factor triggers activation of signal transducer and activator of transcription 3, proliferation, invasiveness, and altered protease expression in choriocarcinoma cells

Extravillous trophoblast cells resemble cancer cells with regard to their intrinsic invasiveness. They invade decidual tissue, but, unlike tumor cells, shut down their invasive properties, when they become inappropriate. Stimuli involved in the modulation of invasion, as well as their underlying signaling mechanisms require further clarification. We were especially interested in discovering signal

Increasing systematicity leads to better selection decisions: Evidence from a computer paradigm for evaluating selection tools.

A computerized paradigm was created to allow for testing in the laboratory whether increasing systematicity helps the recruiter make better selection decisions. Participants were introduced to the job and the applicants on the computer screen and asked to select who they thought should be considered for the job and who should not. Level of systematicity, i.e. the extent to which the recruitment is

Tangible interaction for stroke survivors : Design recommendations

In this paper we outline the initial stages of a human centered design process aimed at the design of novel technology (tangible interactive objects) for stroke survivors. We found it useful to support standard methods, such as interviews and focus groups, with a video prototype in order to make the concept of tangible interaction, which was novel to our users, more clear. In addition we carried o

Home care services for sick children : Healthcare professionals' conceptions of challenges and facilitators

Aims and objectives: To explore healthcare professionals' conceptions of caring for sick children in home care services. Background: Families often prefer home care to hospital care, and the number of home care services for children is increasing. Caring for children at home has been recognised as challenging for healthcare professionals in home care services used to providing care predominately f

Sweden. Legal Philosophy in the 20th Century

The evolution of legal philosophy in Sweden in the first half of the 20th century basically coincides with the history of the so-called Uppsala School, which will be treated extensively in Tome 2 of this volume, in the part devoted to legal realism. Here I will be dealing with Swedish legal philosophy after that period, from the early 1940s onward, when the hitherto dominant influence of the philo

Strains caused by daily loading might be responsible for delayed healing of an incomplete atypical femoral fracture

Atypical femoral fractures are insufficiency fractures in the lateral femoral diaphysis or subtrochanteric region that mainly affect older patients on bisphosphonate therapy. Delayed healing is often seen in patients with incomplete fractures (cracks), and histology of bone biopsies shows mainly necrotic material inside the crack. We hypothesized that the magnitude of the strains produced in the s

A systematic review of studies in the contributions of the work environment to ischaemic heart disease development

BACKGROUND: There is need for an updated systematic review of associations between occupational exposures and ischaemic heart disease (IHD), using the GRADE system.METHODS: Inclusion criteria: (i) publication in English in peer-reviewed journal between 1985 and 2014, (ii) quantified relationship between occupational exposure (psychosocial, organizational, physical and other ergonomic job factors)

Betony (Betonica officinalis) in Stehag – a piece of living plant history.

Betony, Betonica officinalis L., is one ofthe rarest plants in Scandinavia and has the longestdocumented history. It was reported at the parish ofStehag in Skåne, southernmost Sweden, by the Danishhumanist and publisher Christiern Pedersen asearly as 1534, one of the world’s oldest records wherea species is tied to a specific locality. Literature andcollections testify that Betony was commoner in

Effect of sodium nitrite and regulatory mutations Δagr, ΔsarA, and ΔsigB on the mRNA and protein levels of staphylococcal enterotoxin D

Staphylococcal food poisoning results from ingestion of enterotoxins produced by Staphylococcus aureus. Staphylococcal enterotoxin D (SED) is one of the most common toxins detected in S. aureus strains associated with intoxications. The effect of sodium nitrite on enterotoxin production has been only partly investigated, despite its wide usage in meat products. In addition, the factors influencing

Bibliometrics, text mining, and vizualization analyses to support verification and specification of PICO.

We aim to obtain a fast overview of the HTA question and to refine-specify the PICO for information retrieval, using bibliometrics, text mining, and vizualization tools. The PICO question is a well-established format within the HTA process. Depending on the HTA question the PICO can be difficult to verify and limit. To support the HTA-project groups and the informaton specialistst to establish the

TiOx thin films grown on Pd(100) and Pd(111) by chemical vapor deposition

The growth of ultrathin TiOx (0≤x≤2) films on Pd(100) and Pd(111) surfaces by chemical vapor deposition (CVD), using Titanium(IV)isopropoxide (TTIP) as precursor, has been investigated by high resolution photoelectron spectroscopy, low energy electron diffraction and scanning tunneling microscopy. Three different TiOx phases and one Pd-Ti alloy phase have been identified for both surfaces. The Pd-