Quantification and rescue of alpha-synuclein-induced cell growth impair in yeast by high-throughput screening
ABSTRACT Parkinson’s disease (PD) is a common neurodegenerative disorder disease that mostly affects individuals over the age of 50 all over the world. It is caused by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Overexpression or mutation of α-synuclein have been identified as the direct cause of cell loss and dominant inherited PD, although the mechanism i