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BACKGROUND: Standard first-line antiretroviral therapy for HIV-1 infection includes two nucleoside or nucleotide reverse transcriptase inhibitors (NtRTIs), but these drugs have limitations. We assessed the 96 week efficacy and safety of an NtRTI-sparing regimen.METHODS: Between August, 2010, and September, 2011, we enrolled treatment-naive adults into this randomised, open-label, non-inferiority t

Organisationslära är den samlade kunskapsmassa som hjälper oss att beskriva, analysera, förstå och förändra organisationer. Den innehåller teorier om olika slags organisationer och om olika aspekter av vad som sker i organisationer, alltifrån enskilda individers motivation och beteende till organisationers syfte och roll i samhället. Gemensamt för alla organisationer är att skapa värde för sina in

Den här boken handlar om hur man planerar, genomför, avrapporterar och bedömer utredningar, såväl forskningsinriktade som utredningar i praktiken. Författarna diskuterar olika metodologiska synsätt och går igenom olika forsknings- och utredningsmetoder. Vilka är metodernas för- och nackdelar och i vilka situationer kan och bör de tillämpas?Denna fjärde upplaga av boken är kraftigt omarbetad och up

Den här boken sätter fokus på den trend inom företagsorganisation som kallas nätverksorganisation. Det stora integrerade företaget, som håller ihop en hel produktionsprocess, håller på att ersättas av nätverk av företag som specialiserar sig på var sin del av värdekedjan eller produktionsprocessen. Företagsledare höjer sina blickar för att hitta resurser och kompetenser runt om i världen och knyte

Management handlar om att leda såväl verksamheter som människor. Ledning av verksamheter går ut på att utforma och genomföra mål, strategi, organisation och styrning på ett sådant sätt att verksamheten skapar värde för kunder och andra in-tressenter. Att leda människor handlar om att mobilisera lust, energi och engagemang hos de människor, som är verksamma i organisationen.Det unika med denna bok

För att öka genomslag och resultat av politiken och för uppnå det gemensamma uppdraget krävs ett samarbete mellan toppolitiker och toppchefer. Att styra och leda tillsammans kräver ett samspel och en strategi. Här finns ny kunskap och verktyg om vad som behövs för att förtydliga uppdragen och förbättra samarbetet. Rapporten baseras på enskilda intervjuer under våren 2017 i tio kommuner och tre reg

The production of chips is an inevitable part of any machining operation. Today, brass chips are commonly recycled through re-melting by the material supplier implying a “loop” where material is sent back and forth between the material supplier and the manufacturing company. The research presented in this paper evaluates a method for compaction and hot forging of brass chips into blanks for subseq

Background: Relenza represents the first neuraminidase inhibitor (NI), a class of drugs that also includes the drug Tamiflu. Although heralded as breakthrough treatments in influenza, NI efficacy has remained highly controversial. A key unsettled question is why the US Food and Drug Administration (FDA) has approved more cautious efficacy statements in labelling than European regulators for both dBackgroundRelenza represents the first neuraminidase inhibitor (NI), a class of drugs that also includes the drug Tamiflu. Although heralded as breakthrough treatments in influenza, NI efficacy has remained highly controversial. A key unsettled question is why the United States Food and Drug Administration (FDA) has approved more cautious efficacy statements in labelling than European regulators f

In this review, the authors reflect upon the role of coronary physiology in the modern management of coronary artery disease. They critically appraise the scientific background of the instantaneous wave-free ratio (iFR) and fractional flow reserve (FFR), from early experimental studies to validation studies against indexes of ischemia, to clinical trials assessing outcome. At this important junctu

Background: Incidental gallbladder cancer (IGBC) is an unexpected finding when a cholecystectomy is performed upon a benign indication, and the use of routine or selective histological analysis of gallbladder specimen is still debated. The aim of this study was to investigate whether the proportion of submitted gallbladder specimens for pathological investigation influences the proportion of IGBC

Background: Long-term intensive training leads to morphological and mechanical changes in the heart generally known as "athlete's heart". Previous studies have suggested that the diastolic and systolic function of the ventricles is unaltered in athletes compared to sedentary. The purpose of this study was to investigate myocardial performance index (MPI) by pulsed wave Doppler (PWD) and by tissue

This book argues that we are currently witnessing not merely a decline in the quality of social science research, but the proliferation of meaningless research, of no value to society, and modest value to its authors - apart from securing employment and promotion. The explosion of published outputs, at least in social science, creates a noisy, cluttered environment which makes meaningful research

Background: To expand our clinical and scientific knowledge about holistic outcomes within palliative care, there is a need for agreed-upon patient-reported outcome measures. These patient-reported outcome measures then require translation and cultural adaptation, either from country-specific languages to English, or the other way around. The aim of this study was to translate and cross-culturally

A physical network node controls allocation and/or deallocation of resources of an interconnected hardware infrastructure. The physical network node determines a number of requests currently queued at a first service node of a plurality of serially-connected service nodes at a current time. The plurality of serially-connected service nodes supports a packet flow using resources of the interconnect

Background and purpose — Impaction bone grafting (IBG) in revision hip surgery is an established method in restoring bone stock deficiencies. We hypothesized that local treatment of the morsellized allograft with a bisphosphonate in cemented revision would, in addition to increased bone density, also reduce the early migration of the cup as measured by radiostereometry (RSA). Patients and methods

Objective: The objective of this study of distal radius fractures was to determine if a subchondral haematoma in an unfractured compartment predicts secondary osteoarthritis. Methods: In 1995–1997, 41 patients, 22 women, a median age of 41 years (20–57 years) with a displaced distal radius fracture underwent diagnostic wrist arthroscopy in addition to the fracture treatment. In 12 patients (7/12 w

Purpose: Despite availability of multimodal treatment options for acromegaly, achievement of long-term disease control is suboptimal in a significant number of patients. Furthermore, disease control as defined by biochemical normalization may not always show concordance with disease-related symptoms or patient’s perceived quality of life. We developed and validated a tool to measure disease activi

Purpose: Enterolactone (ENL) is formed in the human gut after consumption of lignans, has estrogenic properties, and has been associated with risk of prostate cancer. We examined the association between plasma ENL levels and prostate cancer in a nested case–control study within the population-based Malmö Diet and Cancer cohort. We also examined the association between plasma ENL and dietary and li