Latent autoimmune diabetes in adults (LADA) usually refers to GAD65 autoantibodies (GADAb)-positive diabetes with onset after 35 years of age and no insulin treatment within the first 6 months after diagnosis. However, it is not always easy to distinguish LADA fromtype 1 or type 2 diabetes. In this study, we examined whether metabolite profiling could help to distinguish LADA (n = 50) from type 1

Reduced pancreatic b-cell function or mass is the critical problem in developing diabetes. Insulin release from b-cells depends on Ca2+ influx through high voltage- gated Ca2+ channels (HVCCs). Ca2+ influx also regulates insulin synthesis and insulin granule priming and contributes to β-cell electrical activity. The HVCCs aremultisubunit protein complexes composed of a pore-forming a1 and auxiliar

Underlying type 1 diabetes is a genetic aetiology dominated by the influence of specific HLA haplotypes involving primarily the class II DR-DQ region. In genetically predisposed children with the DR4-DQ8 haplotype, exogenous factors, yet to be identified, are thought to trigger an autoimmune reaction against insulin, signalled by insulin autoantibodies as the first autoantibody to appear. In child

Background: Attitudes toward diabetes care are different between genders and age-groups. Furthermore, diabetes related challenges may cause psychosocial problems. Therefore, we were to compare the psychosocial status and glycemic control in women and men with type 2 diabetes (T2D) in different age-groups. Methods: 441 adults with T2D were recruited. Demographic, self-care behavior, resources and a

Purpose: The purpose of the study, upon which this paper is based, was to contribute an improved understanding of the vertical extension of buildings, by presenting a development process for its implementation in which the key aspects to consider when planning such extensions are highlighted. Design/methodology/approach: The approach is based on linking the diffusion of innovation together with ca

Historically, home economics (HE) in general, and the consumer education sections in particular, have been criticized for transferring norms and values of conservative elites to the masses. This is in stark contrast to contemporary theoretical views of a modern HE aimed at educating emancipated and critical citizens, and also to modern curricula that emphasize the consequences of consumption rathe

Offspring of women with gestational diabetes mellitus (GDM) are at increased risk of developing metabolic disease, potentially mediated by epigenetic mechanisms. We recruited 608 GDM and 626 control offspring from the Danish National Birth Cohort, aged between 9 and 16 years. DNA methylation profiles were measured in peripheral blood of 93 GDM offspring and 95 controls using the Illumina HumanMeth

Severe lung inflammation and alveolar hemorrhage can be life-threatening in systemic lupus erythematosus (SLE) patients if not treated early and aggressively. Neutrophil influx is the driver key of this pathology, but little is known regarding the molecular events regulating this recruitment. Here, we uncover a role for IL-16/mir-125a in this pathology and show not only that IL-16 is a target for

PurposeThe purpose of this paper is to explore how witnessing workplace incivility from coworkers and supervisors relates to instigating incivility toward others. A further aim was to investigate if witnessed incivility is indirectly related to instigated incivility via perceived stress and low job satisfaction. An additional aim was to study if control, social support and job embeddedness moderat

This report aims at providing information on principles that should be considered during planning, establishment and maintenance of work zones, and inspection works. An extensive literature review has been done within the project and some of the results, e.g. of previous CEDR-projects, are included in IRIS. However, not all findings of recent studies are mentioned, as the goal was to keep the repoThis report aims at providing information on principles that should be considered during planning, establishment and maintenance of work zones, and inspection works. An extensive literature review has been done within the project and some of the results, e.g. of previous CEDR-projects, are included in IRIS. However, not all findings of recent studies are mentioned, as the goal was to keep the repo

Limited guidance is available to engineers on how people's walking speed in smoke can and should be represented in the fire safety design process of underground transportation systems, such as road and rail tunnels. To address this issue, the behaviour and movement of people in case of evacuation due to a fire in underground transportation systems has been investigated. In this paper, the relation

Key message: A 6–9 month backward time shift of the carbon uptake gave the highest correlation between annual biomass increment and carbon uptake in this old even aged forest. Abstract: Plants’ carbon uptake and allocation to different biomass compartments is an important process for both wood production and climate mitigation. Measurements of the net ecosystem carbon dioxide exchange between ecos

Background: There exist few recovery and occupation-based interventions for mental health service users. Balancing Everyday Life (BEL) is a new occupation-based lifestyle intervention that was created to fill this need. Aim: To gain group leaders’ and participants’ perspectives of the BEL intervention content and format, including factors that helped, hindered, and could be improved. Methods: A co

The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of the heritability of this disease. Here, to test the hypothesis that

Objective: To validate a 7-day estimated dietary record routine with standardized portion sizes and household measuring in a clinical setting with the doubly labelled water (DLW) method as the reference method. Design: Energy expenditure was measured with deuterium (2H) and oxygen-18 (18O), and water loss was estimated by 2H dilution as part of the DLW measurements. Energy and water intake was mea

Protein-coding genetic variants that strongly affect disease risk can yield relevant clues to disease pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals with type 2 diabetes (T2D) and 24,440 non-diabetic control participants from 5 ancestries. We identify gene-level associations of rare variants (with minor allele frequencies of less than 0.5%) in 4 genes at exome-wide si

The paper analyses dwell time delays for commuter trains in Stockholm and Tokyo. In both cities, small dwell time delays of at most five minutes make up around 90% of the total delays. Therefore, it is valuable to understand and deal with these disturbances. To this end, we use high resolution data on dwell times and passenger counts from both countries over the last several years. We find that thThe paper analyses dwell time delays for commuter trains in Stockholm andTokyo. In both cities, small dwell time delays of at most five minutes makeup around 90% of the total delays. Therefore, it is valuable to understandand deal with these disturbances. To this end, we use high resolution data ondwell times and passenger counts from both countries over the last severalyears. We find that these d