Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) dat

Northern regions have received considerable attention not only because the effects of climate change are amplified at high latitudes but also because this region holds vast amounts of carbon (C) stored in permafrost. These carbon stocks are vulnerable to warming temperatures and increased permafrost thaw and the breakdown and release of soil C in the form of carbon dioxide (CO2) and methane (CH4).

Optimising autonomy is increasingly important in recovery from psychosis. To date, physical exercise has shown promise in the treatment of severe, enduring mental illnesses including psychosis - when used as an adjunct treatment. To assess the association between physical exercise and autonomy in young adults, a simple pre-post experimental design was utilised. Individuals aged 18–35 years, treate

Background: Hip fractures are described to have a significant impact on patients' well-being and different fast-track concepts could result in a reduction of the patient's psychological and emotional reactions before pre- and intrahospital care. Aims and objectives: This study aimed to elucidate perceived situations of significance experienced by patients with hip fracture during the prehospital-

Subarctic ecosystems are predicted to experience the fastest responses to climate change on the planet, with dramatically altered vegetation patterns, frost dynamics and hydrological flow paths. The resulting change in dissolved organic carbon (DOC) export to river systems is poorly known, but reports of rising DOC in northern surface waters have led to widespread speculations on a possible climat

The contribution of terrestrially-derived carbon to micro-crustacean zooplankton biomass (i.e. allochthony) has been previously studied in lakes and reservoirs, but little is known about allochthony in rivers. We hypothesized that restricted selective grazing in turbulent environments such as rivers would decouple zooplankton from specific microbial and algal food resources, such that their alloch

The success of sustainable building renovation is inevitably dependent on the capabilities of the involved stakeholders throughout the entire project. Therefore, any building client with intentions of sustainable building renovations must reflect on sourcing the adequate capabilities for a sustainable renovation project. The question in focus is: how to facilitate a sourcing strategy for energy-ef

The exact physiological role for the monoamine serotonin (5-HT) in modulation of insulin secretion is yet to be fully understood. Although the presence of this monoamine in islets of Langerhans is well established, it is only with recent advances that the complex signaling network in islets involving 5-HT is being unraveled. With more than fourteen different 5-HT receptors expressed in human islet

The term Bildung did not exist in the Reformation era. Rather, one spoke of "the Learned World." Coming up in the Renaissance, the Reformation was influenced by humanism and its prominent figures Johann Reuchlin and Erasmus of Rotterdam and their interest in the classical heritage with Latin as the scholarly lingua franca. Both Luther and Melanchthon attached themselves directly to that tradition

BackgroundInternationalisation of higher education involving information and communication technology such as e-learning opens opportunities for innovative learning approaches across nations and cultures.ObjectivesDescribe a case in practice of collaborative and transformative learning in relation to ‘internationalisation on home grounds’ with the broader learning objective of ‘becoming aware and

Diabetes is a major risk factor for cardiovascular disease and this is in part due to the effects of hyperglycemia on vascular smooth muscle cells. Small non-coding microRNAs are known to control smooth muscle phenotype and arterial contractility and are dysregulated in diabetes. The effect of microRNAs on smooth muscle differentiation is in part mediated by the transcription factor KLF4 but the r

Non-suicidal self-injury (NSSI) is self-inflicted physical harm that is associated with suicidality, although it is not an expression of suicidal intent. NSSI behaviours range from minor skin scratching to injury requiring medical attention, and in extreme cases, death. NSSI is understood as an effort to modulate emotion in times of crisis and distress. Causal models have been developed for self-h

Purpose: This article presents a discussion of how librarians' engagement in certain social movements manifests itself in public libraries, how librarians justify their engagement with specifically the LGBT + movement and the climate movement and what it might entail in terms of legitimacy. Design/methodology/approach: Besides an extensive international literature on libraries and climate/LGBT + i

AbstractEndocarditis, or heart valve infection, can be caused by a number of pathogens, many of which are Gram-positive bacteria. The diagnosis is based on imaging techniques such as echocardiography and on blood culture. The implementation of fast and accurate species identification methods, such as the matrix-assisted laser desorption/ionisation-time of flight mass spectrometry (MALDI-TOF MS) in

The human Transient Receptor Potential A1 (hTRPA1) ion channel, also known as the wasabi receptor, acts as a biosensor of various potentially harmful stimuli. It is activated by a wide range of chemicals, including the electrophilic compound N-methylmaleimide (NMM), but the mechanism of activation is not fully understood. Here, we used mass spectrometry to map and quantify the covalent labeling in