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The practice of using quantitative risk assessments (QRAs) for managing risks in land-use planning varies between countries. Some regulatory regimes are highly prescriptive in terms of explicit requirements on methodology, assumptions, modelling tools, input data, risk criteria, etc. Others require risk analyses to support decision-making without regulating the details. The present study seeks to
Type 2 diabetes (T2D) is a global public health challenge. Whilst the advent of genome-wide association studies has identified >400 genetic variants associated with T2D, our understanding of its biological mechanisms and translational insights is still limited. The EPIC-InterAct project, centred in 8 countries in the European Prospective Investigations into Cancer and Nutrition study, is one of th
Robustness is a prominent feature of most biological systems. Most previous related studies have been focused on homogeneous molecular networks. Here we propose a comprehensive framework for understanding how the interactions between genes, proteins and metabolites contribute to the determinants of robustness in a heterogeneous biological network. We integrate heterogeneous sources of data to cons
Urban flooding is a growing concern in Northern Europe. While all countries in this region invest substantial resources into urban flood risk management, all property owners have unequal opportunity to have their flood risk managed. This paper presents the notion of equity in the urban flood risk management, focusing on urban flood exposure and compensation after sewage surcharge on the 31 August
PurposeThe purpose of this paper is to investigate public partners’ motives for seeking and/or accepting partnerships with third sector organisations.Design/methodology/approachThe approach is to seek to identify and explain motives from different perspectives; as responses to government failure or voluntary failure, as related to governance structures, and/or as driven by resource dependencies. T
The common patatin-like phospholipase domain-containing protein 3 (PNPLA3) variant I148M predisposes to nonalcoholic liver disease but not its metabolic sequelae. We compared the handling of labeled polyunsaturated fatty acids (PUFAs) and saturated fatty acids (SFA) in vivo in humans and in cells harboring different PNPLA3 genotypes. In 148M homozygous individuals, triglycerides (TGs) in very low-
Background: The FreeStyle Libre glucose sensor has caused many cases of allergic contact dermatitis, and isobornyl acrylate (IBOA) in this sensor has been identified as one of the culprit allergens. Objectives: To report on the presence of IBOA in devices produced by Medtronic, namely, Enlite sensor and insulin infusion set Paradigm MiniMed Quick-set. Patients and Methods: Five patients reacting t
Probiotics are linked to positive regulatory effects on the immune system. The aim of the study was to examine the association between the exposure of probiotics via dietary supplements or via infant formula by the age of 1 year and the development of celiac disease autoimmunity (CDA) and celiac disease among a cohort of 6520 genetically susceptible children. Use of probiotics during the first yea
Objectives: The parts of constructive alignment, i.e. learning objectives, activities and assessment are crucial for good learning outcomes. However, they must constantly be evaluated so as to verify the alignment. Our aim was to investigate if attendance to our casebased seminars in family medicine contributed to exam performance and whether gender had any impact for undergraduate students at the
‘Sustainability’, often presented through an ecological–economic–social triad, is today one of spatial planning’s absolute key concepts (and key priorities). But it is also a highly contested concept, whose meaning is often considered evasive or vague. In this paper, we try to counterweigh such evasiveness by putting emphasis on the material landscape produced within a project that is frequently d
This paper seeks to improve the understanding of the interaction between patients with stroke and the physical environment in their home settings. Stroke care is increasingly performed in the patient's home. Therefore, a systematic review was conducted to identify the existing knowledge about facilitators and barriers in the physical environment of home settings for the stroke rehabilitation proce
"In what language would one polyglot praise another? Multilingualism and linguistic patriotism in the light of a letter and a poem from Magnus Gabriel Block to Sophia Elisabeth Brenner." In the late 17th and the early 18th centuries, there was a dialectic relation between the increasing national concern for the native language on one hand, and the international multilingual culture where Latin was
Industrialized production of building components, or entire houses, reduces activities at the construction site to the assembly of parts and has the potential to increase productivity and reduce the design effort invested in every project. However, in order to realize all of the potential efficiency gains that use of predefined components could deliver effective, interoperable information manageme
In Nazi Germany 1933-1945 the medical profession played an important role, not only within the health sector but also for ideological purposes. Some physicians committed criminal acts during the war, for example in concentration camps, and where later put on trial at the Nuremberg Trials in 1946-1947, some of them also sentenced to death. What is little known outside Germany is the existence of a
The word plus(s) can function as a conjunction in Scandinavian, and as such coordinate for example embedded clauses introduced by the subjunction at(t). However, one can also find examples of clauses introduced by plus(s) at(t) although not preceded by another at(t)-clause. These constructions, which represent a relatively new development in Scandinavian, are semantically similar to coordinations
