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Glucocorticoid use is associated with steroid-induced diabetes mellitus and impaired pancreatic β-cell insulin secretion. Here, the glucocorticoid-mediated transcriptomic changes in human pancreatic islets and the human insulin-secreting EndoC-βH1 cells were investigated to uncover genes involved in β-cell steroid stress-response processes. Bioinformatics analysis revealed glucocorticoids to exert

The European spruce bark beetle (Ips typographus L.) is a major disturbance agent in Norway spruce (Picea abies (L.) Karst) forests in Europe and it is estimated that a changing climate will result in more severe outbreaks in the future. To reduce the risk of large outbreaks it is important to have methods that enable early detection of bark beetle attacks to help forest managers to prevent popula

Importance: The prognostic impact of parenteral nutrition duration (PND) on retinopathy of prematurity (ROP) is not well studied. Safe prediction models can help optimize ROP screening by effectively discriminating high-risk from low-risk infants. Objective: To evaluate the prognostic value of PND on ROP; to update and validate the Digital ROP (DIGIROP) 2.0 birth into prescreen and screen predicti

Kan framtidens shoppingupplevelse redan ha varit här? Ja mycket av det som av både upplevelse- och hållbarhetsskäl anses tillhöra framtidens konsumtion dominerade butikslokalerna i svenska städer för hundra år sedan. Det såldes livsmedel i lösvikt, man behövde handla dagligen eftersom ingen hade kylskåp hemma och det fanns många verkstäder och skräddare där man beställde precis det man behövde (oc

Primary and secondary bile acids (BAs) influence metabolism and inflammation, and the gut microbiome modulates levels of BAs. We systematically explore the host genetic, gut microbial, and habitual dietary contribution to a panel of 19 serum and 15 stool BAs in two population-based cohorts (TwinsUK, n = 2,382; ZOE PREDICT-1, n = 327) and assess changes post-bariatric surgery and after nutritional

Crises often reveal a mismatch between organizational and problem structures, demanding interorganizational coordination or new organizational solutions. Much is known about functions and roles of such organizational solutions, but less about the processes underlying them. This study investigates the processes behind the emergence and institutionalization of organizational solutions to meet new co

The purpose of this study is to provide a system perspective on the barriers to the development of a fossil-free and thus more sustainable urban freight system and to provide insights regarding these barriers and how they impede progress. The system perspective complements earlier research, where barriers were identified in delimited parts of freight systems. Here, the urban freight system in a Sw

In this seventh edition of the Excellent MSc Dissertation series, four students present condensed versions of their Master’s theses, completed for the MSc degree in Media and Communication Studies at Lund University. Separately and together, the four contributions in this book exemplify what staff at the Department of Communication and Media consider to comprise an excellent dissertation at the Ma

Acquired haemophilia A (AHA) is a rare bleeding disorder caused by acquired antibodies against coagulation factor VIII. In the Nordic countries, treatment and outcomes have not been studied in recent times. To collect retrospective data on patients diagnosed with AHA in the Nordic countries between 2006 and 2018 and compare demographic data and clinical outcomes with previously published reports,

Background: Five workers from an industry manufacturing various articles from carbon fibre reinforced epoxy plastics were referred to our department because of suspected occupational allergic contact dermatitis (OACD). When patch tested, four of them had positive reactions to components of epoxy resin systems (ERSs) that could explain their current skin problems. All of them had been working at th

OBJECTIVE: Most parents yearn for a second-trimester ultrasound examination and feel excitement about it, but some also worry about what the examination will show. According to prior research, using only generic instruments or specific questionnaires, anxiety decreases when the ultrasound findings are normal. The aim of this study was to compare parents' worry (Parents' Expectations, Experiences,