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Departing from the renewed interest within economic history and neo-Schumpeterian perspectives on growth and economic transformation, we will suggest a theoretical framework for analyzing long term regional economic growth and transformation. Emphasis will be given to different driving forces and their various roles over time, lead-lag relations between industries and how divergence and convergenc

In a previous study from our laboratory, high tumor levels of tissue inhibitor of metalloproteinases-1 (TIMP-1) have been associated with an adverse response to chemotherapy in metastatic breast cancer suggesting that TIMP-1, which is known to inhibit apoptosis, may be a new predictive marker in this disease. The purpose of this study was to investigate the association between TIMP-1 and objective

The clinical onset of type 1 diabetes or autoimmune diabetes occurs after a prodrome of islet autoimmunity. The warning signals for the ensuing loss of pancreatic islet beta cells are autoantibodies against insulin, GAD65, IA-2, and ZnT8, alone or in combinations. Autoantibodies against e.g. insulin alone have only a minor risk for type 1 diabetes. However, progression to clinical onset is increas

To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association sign

Whilst life cycle assessment (LCA) boundaries are expanded to account for negative indirect consequences of bioenergy such as indirect land use change (ILUC), ecosystem services such as water purification sometimes delivered by perennial bioenergy crops are typically neglected in LCA studies. Consequential LCA was applied to evaluate the significance of nutrient interception and retention on the e

Insulin resistance is a key mediator of obesity-related cardiometabolic disease, yet the mechanisms underlying this link remain obscure. Using an integrative genomic approach, we identify 53 genomic regions associated with insulin resistance phenotypes (higher fasting insulin levels adjusted for BMI, lower HDL cholesterol levels and higher triglyceride levels) and provide evidence that their link

Innovations in the lighting sector, such as LED-based light sources, have opened up unprecedented possibilities to both save energy and improve the quality of lighting. There is growing evidence of light's importance for human health, moods, work productivity and quality of life in general; but the uptake of new solutions is still rather slow in society. The public sector can play an important rol

Increased estuarine input and subsequent degradation of dissolved organic carbon (DOC) is a potentially important cause of rising CO2 concentrations that contribute to coastal marine acidification. However, it is not clear whether or not the evolved CO2 originates from the decomposition of terrestrially-derived DOC. We recorded the changes in δ13C and δ2H of dissolved organic matter during laborat

Gaming among young people with disabilities is often understood within a habilitation frame, as if video and computer games primarily should help to exercise and ‘improve’. Little is known about how these games are used within a private frame, and how young people with disabilities operate their gaming as concrete persons rather than as treatment-receiving clients. Through the use of stories, desc

Finding new causes of monogenic diabetes helps understand glycaemic regulation in humans. To find novel genetic causes of maturity-onset diabetes of the young (MODY), we sequenced MODY cases with unknown aetiology and compared variant frequencies to large public databases. From 36 European patients, we identify two probands with novel RFX6 heterozygous nonsense variants. RFX6 protein truncating va

Aims To identify areas in need of quality improvement by investigating inpatients' perceptions of quality of care, and to identify differences in perceptions of care related to patient gender, age and type of admission. Background Nursing managers play an important role in the development of high-quality care. Methods Quality of care was assessed using the Quality from the Patients' Perspective (Q