There are broad calls in national and international forest policy processes for basing decision-making on the best obtainable scientific knowledge. Simultaneously, there is also a need to accommodate plural values and objectives people and society in general have associated with forests. An essential step for building an evidence base that accommodates pluralistic understandings is to capture info

Housing provisions in the Western world, Australia included, are characterised by several challenges. New residential typologies are needed to cope with, for example, environmental and economic considerations of land use, escalating construction cost, and the lack of affordable housing. Urban form determines measures of density. It also spurs our common imaginaries of urban life. Hence,to calibrat

The global energy transition is not merely a technological shift toward renewable energy but also a transformation of power structures, agency, and governance. As nations and cities implement sustainable energy solutions, both traditional energy actors and new entrants are reshaping participation in the energy sector. Within this evolving context, the smart grid emerges as an arena where these dyn

Background: Smooth muscle cells are important for atheroscleroticplaque stability. Their proper ability to communicatewith the extracellular matrix is crucial for maintainingthe correct tissue integrity. In this study, we have investigatedthe role of β-sarcoglycan within the matrix-binding dystrophin-glycoproteincomplex in the development of atherosclerosis.Results: Atherosclerotic plaque developm

Genome-wide association studies (GWAS) in coronary artery disease (CAD) had identified 66 loci at 'genome-wide significance' (P < 5 × 10 '8) at the time of this analysis, but a much larger number of putative loci at a false discovery rate (FDR) of 5% (refs. 1,2,3,4). Here we leverage an interim release of UK Biobank (UKBB) data to evaluate the validity of the FDR approach. We tested a CAD phenotyp

Purpose: To evaluate how children with spina bifida (SB) participate in school-related activities and to explore if their motor and process skills in task performance were related to their level of active participation in school. Method: Fifty children from a geographical cohort of children with SB (aged 6-14 years) and their teachers rated the children's frequency of participation in school-relat

We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49 distinct association signals at these loci, including five mapping in or near KCNQ1. 'Credible sets' of the variants most likely to drive each distinct signal mapped predominantly to noncoding sequence, implying that association with T2D is mediated thro

The exegetical subjects have a particular interdisciplinary role within academia, implying that their responsibilities and significance are – and should be – under constant debate. In his article, church historian Joel Halldorf, argues for the overt use of theological interpretations (in the narrow sense of "normative theology") in the exegetical discipline. Halldorf thereby highlights some currenThe exegetical subjects have a particular interdisciplinary role within academia, implying that their responsibilities and significance are – and should be – under constant debate. In his article, church historian Joel Halldorf, argues for the overt use of theological interpretations (in the narrow sense of "normative theology") in the exegetical discipline. Halldorf thereby highlights some curren

BACKGROUND: Proteomic approaches allow measurement of thousands of proteins in a single specimen, which can accelerate biomarker discovery. However, applying these technologies to massive biobanks is not currently feasible because of the practical barriers and costs of implementing such assays at scale. To overcome these challenges, we used a "virtual proteomic" approach, linking genetically predi

Glucocorticoid use is associated with steroid-induced diabetes mellitus and impaired pancreatic β-cell insulin secretion. Here, the glucocorticoid-mediated transcriptomic changes in human pancreatic islets and the human insulin-secreting EndoC-βH1 cells were investigated to uncover genes involved in β-cell steroid stress-response processes. Bioinformatics analysis revealed glucocorticoids to exert

Based on an extensive cohort study over 25 years, the present study supports the assumption that major osteoporotic fractures can be reasonably predicted from hip fracture rates. The construct for FRAX models depends on algorithms to adjust for double counting of fracture outcomes in some models and in others, to estimate the incidence of a major fracture from hip fracture rates. The aim of the pr

A sizable fraction of testicular germ cell tumour (TGCT) risk is expected to be explained by heritable factors. Recent genome-wide association studies (GWAS) have successfully identified a number of common SNPs associated with TGCT. It is however, unclear how much common variation there is left to be accounted for by other, yet to be identified, common SNPs and what contribution common genetic var