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Hypersecretion of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) has been associated with obesity and glucose intolerance. This condition has been suggested to be linked to GIP resistance. Besides its insulinotropic effect, GIP also directly affects glucose uptake and lipid metabolism. This notwithstanding, effects of GIP on other circulating metabolites than glucose have

Atherosclerosis is the primary cause of acute myocardial infarction and stroke. It is well established that arterial inflammation in response to accumulation and oxidation of lipoproteins in the vascular wall is the major factor responsible for the development of atherosclerosis. During recent years, it has become apparent that this vascular inflammation is modulated by a complex array of autoimmu

About a quarter of all meteorites falling on Earth today originate from the breakup of the L-chondrite parent body similar to 470 Ma ago, the largest documented breakup in the asteroid belt in the past similar to 3 Ga. A window into the flux of meteorites to Earth shortly after this event comes from the recovery of about 100 fossil L chondrites (1-21 cm in diameter) in a quarry of mid-Ordovician l

Gastric bypass (GBP) results in rapid type 2 diabetes (T2D) remission in most cases. Consequences of GBP reversal are unknown. A GBP-operated T2D patient was given mixed-meal tests before (MMTpre), 2 months (MMT2-M) and 12 months (MMT12-M) after GBP reversal. Glucose, hormones and metabolite profiles were assessed. MMT2-M displayed slightly lower glucose levels; MMT12-M displayed higher glucose an

Observational epidemiology has made outstanding contributions to the discovery and elucidation of relations between lifestyle factors and common complex diseases such as type 2 diabetes. Recent major advances in the understanding of the human genetics of this disease have inspired studies that seek to determine whether the risk conveyed by bona fide risk loci might be modified by lifestyle factors

Helianthemum nummularium (L.) Mill. has two subspecies in southern Scandinavia, which differ in an indumentum character that is inherited as a Mendelian gene with two alleles. The dominant allele is the genetic basis for the key character of subsp. obscurum (absence of a dense felt of stellate hairs on the abaxial surface of the leaf), whereas the recessive allele is the genetic basis for the key

Macrophages control the resolution of inflammation through the transition from a proinflammatory (M1) to an anti-inflammatory (M2) phenotype. Here, we present evidence for a role of AMPK alpha 1, a master regulator of energy homeostasis, in macrophage skewing that occurs during skeletal muscle regeneration. Muscle regeneration was impaired in AMPK alpha 1(-/-) mice. In vivo loss-of-function (LysM-

Type 2 diabetes is triggered by reduced insulin production, caused by genetic and environmental factors such as inflammation originating from the innate immune system. Complement proteins are a component of innate immunity and kill non-self cells by perforating the plasma membrane, a reaction prevented by CD59. Human pancreatic islets express CD59 at very high levels. CD59 is primarily known as a

Secretion from many endocrine cells is a result of calcium-regulated exocytosis due to Ca(2+) influx. Using the patch-clamp technique, voltage pulses can be applied to the cells to open Ca(2+) channels, resulting in a measurable Ca(2+) current, and evoke exocytosis, which can be seen as an increase in membrane capacitance. A common tool for evaluating the relation between Ca(2+) influx and exocyto

Short-chain fatty acids (SCFA) are involved in immune system and inflammatory responses. We comprehensively assessed the host genetic and gut microbial contribution to a panel of eight serum and stool SCFAs in two cohorts (TwinsUK, n = 2507; ZOE PREDICT-1, n = 328), examined their postprandial changes and explored their links with chronic and acute inflammatory responses in healthy individuals and

Our paper starts with a reflection on how the classic left and right-wing scale has become less relevant in modern politics. Instead, we argue that completely new divisions in society are being formed. Examples are issues of globalization, immigration and identity. These are questions often associated with the other axis of the political scale - conservative or progressive. To examine this in prac

Syftet med den aktuella studien var att undersöka om en intervention i positiv psykologi kunde leda till ett ökat välbefinnande hos elever i årskurs 1-6 på en svensk grundskola. Det undersöktes även om interventionen hade olika effekt i olika årskurser. Frågeformulär administrerades före och efter interventionen. Enstaka frågor om trivsel i skolan, psykosomatiska besvär och mobbning samt Students’

Den föreliggande studien grundades på tidigare forskning som funnit samband mellan email-användande och stressrelaterade sjukdomar, såsom utbrändhet och emotionell utmattning, samt en ökad daglig stress. Syftet med studien var att undersöka om det finns ett samband mellan email overload, copingstrategier och upplevd stress. Vidare frågeställningar som studien baserades på var ifall det finns ett sThe present study was based on previous research that has found connections between email usage and stress-related diseases, such as burnout and emotional exhaustion, as well as an increased daily stress. The purpose of the study was to investigate whether there is a connection between email overload, coping strategies and percieved stress. Further issues on which the study was based was if there

In the name of collaboration : The significant meaning of a consultation team from a neoinstitutional perspective. Collaboration between human service organizations is to be considered desirable however also known to be hard to accomplish. The aim of this case study was to examine the phenomenon of inter-organizational collaboration by describing and analyzing the significant meaning of a consult

Urban environments are rapidly growing worldwide with severe consequences to animals and plants residing in our cities. Some of the most well-studied urban wildlife is passerine birds, where a wide array of effects have been documented; smaller clutches, earlier breeding, shorter telomeres and oxidative stress are just some costs among numerous others. Yet, few studies have so far investigated the

Bakgrund: Äldre människor som upplever negativa hälsoeffekter av ensamhet är kontraproduktivt och skadande för samhället. Hälsan kan påverkas av aktivitetsbalans, mening och samhörighet mellan människor och husdjur. Syfte: Syftet med studien är att undersöka husdjurs betydelse i det dagliga livet gällande aktivitetsbalans, mening och ensamhet för äldre personer i ordinärt boende. Metod: En kvalitaBackground: Elderly people that experience negative effects on their health due to loneliness is counterproductive. Health can be affected by occupational balance, meaning and fellowship between humans and pets. Aim: The aim of this study is to investigate pets significance in the daily life regarding occupational balance, meaning and loneliness of elderly people living in ordinary housing. Method