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This study presents a deterministic, lumped model to simulate mesoscale sustainable drainage systems (SuDS) based on a conceptualization of the stormwater control measures (SCMs) making up the system and their influence on the runoff process. The conceptualization mainly relies on parameters that are easily quantifiable based on the physical characteristics of the SCMs. Introducing a nonlinear res

Cellular metabolite balance and mitochondrial function are under circadian control, but the pathways connecting the molecular clock to these functions are unclear. Peroxisome proliferator-activated receptor delta (PPARδ) enables preferential utilization of lipids as fuel during exercise and is a major driver of exercise endurance. We show here that the circadian repressors CRY1 and CRY2 function a

Informal leaders in the choral voice.Choir leaders’ experience of collaboration between the choristers.Most choirs and choir leaders have the aim to make the individual voices soundas unison as possible in the different choral voices, according to both timing,synchronisation and vocal blend.The aim of the present study was to investigate experienced choir leaders’experience and understanding of po

Mitochondrial metabolism is a major determinant of insulin secretion from pancreatic β-cells. Type 2 diabetes evolves when β-cells fail to release appropriate amounts of insulin in response to glucose. This results in hyperglycemia and metabolic dysregulation. Evidence has recently been mounting that mitochondrial dysfunction plays an important role in these processes. Monogenic dysfunction of mit

Stroke is a life threatening medical condition that is caused either by a blood clot or a bleeding inside the brain. It is generally agreed that immediate treatment of stroke patients is crucial for their ability to recover; however, before treatment can be initiated, the stroke patient has to be diagnosed using, for example, a computed tomography scan of the brain. This, in turn, requires that th

Our understanding of celiac disease and how it develops has evolved significantly over the last half century. Although traditionally viewed as a pediatric illness characterized by malabsorption, it is now better seen as an immune illness with systemic manifestations affecting all ages. Population studies reveal this global disease is common and, in many countries, increasing in prevalence. These s

Overall survival of patients with metastatic non-small cell lung cancer (NSCLC) has significantly improved with platinum-based salt treatments and recently with targeted therapies and immunotherapies. However, treatment failure occurs due to acquired or emerging tumor resistance. We developed a monoclonal antibody against the proform of neurotensin (LF-NTS mAb) that alters the homeostasis of tumor

While measures to prevent the spread of COVID-19 disturbed both global and local markets, some commentators also argued that the pandemic could be seen as the beginning of the end of neoliberalism. Although neoliberal reforms have come under pressure, little is known about the implications of COVID-19 in or across specific sectors. Scaling down the rich theoretical–historical debates about neolibe

Extreme weather events like floods are expected to become more common asclimate change continues, putting health at risk. Systems should be able tocontinue delivering essential health services when shocked by events like floodsand provide care for the expected new health needs caused by the shock.Resilient health systems have the capacity to maintain their functions and tochange when shocked, enab

In this paper, we describe Docforia, a multilayer document model and application programming interface (API) to store formatting, lexical, syntactic, and semantic annotations on Wikipedia and other kinds of text and visualize them. While Wikipedia has become a major NLP resource, its scale and heterogeneity makes it relatively difficult to do experimentations on the whole corpus. These experimenta

The labor market is strongly gender segregated with few women working in the tech sector (e.g. IT) and few men working in the care sector (e.g. nursing). We tested the hypothesis that middle school students strongly associate technology with men and caregiving with women, and that this relates to girls’ lower interest in tech-focused educations. We measured technology/caregiving gender stereotypes

In this paper, we present a system for extracting tabular information from loosely structured handwritten documents. The system consists of three parts, (i) a u-net like CNN-based method for text detection and segmentation, (ii) a new attention-based method for simultaneous text recognition and classification of word-parts, and (iii) a method for matching the word parts into a tabular structure fo

Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), le

The late Cambrian Steptoean positive carbon isotope excursion (SPICE) represents a major perturbation to the global carbon cycle and was associated with trilobite extinctions and expansion of anoxic and/or euxinic water masses during episodes of eustatic sea-level change. We present a new Re-Os age together with Os and Nd isotope stratigraphy and major and trace-element data from the Alum Shale Fo

Universal Design for Learning (UDL) is considered an approach to include all students in the university. UDL is based on three main principles providing multiple means of Engagement, multiple means of representation, and multiple means of action and expression. It is relevant for teachers and departments to focus on more flexibility for students to get the required information, expressing their th