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Expression of fat mass and obesity-associated gene (FTO) and ADP-ribosylation factor-like 15 (ARL15) in human islets is inversely correlated with HbA1c. However, their impact on insulin secretion is still ambiguous. Here in, we investigated the role of FTO and ARL15 using GRINCH (Glucose-Responsive Insulin-secreting C-peptide-modified Human proinsulin) clonal rat β-cells. GRINCH cells have inserte

The role of terrestrial organic carbon for recipient aquatic ecosystems is intensively researched. A multitude of studies now show that terrestrially-derived carbon supports a significant share (allochthony) of consumer biomass in many freshwaters. However, little is known about the mechanisms by which terrestrially-derived carbon is transferred to the level of metazoan zooplankton, and whether th

An important component of the carbon cycle is the lateral flow of dissolved organic carbon (DOC) from terrestrial ecosystems to streams and rivers. The fate of this carbon depends very much on the bioavailability of DOC (BDOC), which may determine whether DOC is returned to the atmosphere as CO2 or deposited in sediments. This study focuses on the linkages between stream DOC composition, optical c

Return to Kashgar – the Jarring Collection of Uyghur Manuscripts Kashgar was a major crossroads for trade and culture along the Eurasian Silk Route for thousands of years, a place where Turkic, Persian, Arab, Chinese and other groups interacted. The Lund University Library is privileged to hold some 600 handwritten books from the sixteenth to the twentieth centuries from cities in this region like

A socially mixed population is a political ambition in Stockholm. By providing a mix of tenure alternatives throughout all neighbourhoods this objective could, at least partially, be fulfilled. Since current tenure proportions display a weak balance in many neighbourhoods it could be assumed that governing politicians – by primarily utilizing Stockholm’s vast landownership and municipal housing de

Results from previous research suggest that the ability to manage ambiguous problems during acute emergency and disaster management is a desirable quality among decision-makers. Ambiguity is a perception that arises when the problem-solver is dissatisfied with his or her understanding of the structure of the problem, and consequently of the problem-solving process. This article presents the result

Workplace surveys are used in workplace health promotion as a basis for improvements at the workplace. But there is lack of psychometrically and qualitatively validated work-health related instruments with a salutogenic approach. The purpose of this study was, therefore, to evaluate the two instruments, the Salutogenic Health Indicator Scale and the Work Experience Measurement Scale, among staff o

In Activity Based Working Environment (ABWE) offices, employees are allowed increased autonomy and are expected to choose where, when, with whom, and to some degree with what, to work; in other words, employees are expected to self-lead to a higher degree and to coordinateand align with colleagues. Effectsof these expectations on employees’cognitive stress and performanceare understudied. In the p

During the transition to a market economy, many countries with a planned economy in Central and Eastern Europe face similar challenges when the established socio-economic systems and infrastructures deemed inefficient in a market economy. Also new issues are being raised by the trends of globalization and the vision of sustainable development. In the energy sector the challenges raised by the Kyot

The plasma metabolome is associated with multiple phenotypes and diseases. However, a systematic study investigating clinical determinants that control the metabolome has not yet been conducted. In the present study, therefore, we aimed to identify the major determinants of the plasma metabolite profile. We used ultra-high performance liquid chromatography (UHPLC) coupled to quadrupole time of fli

The urban water crisis, including issues of water scarcity, pollution and flooding, is one of the key challenges for sustainable urban development. Reasons are manifold. Preventive measures are for instance being put on the back burner, while re-active measures and siloed governance are daily business, resulting in power struggles and ineffective governance. As the water crisis hits the most vulneWe are in the midst of a water crisis. Scarcity, pollution and flooding are some of today’s key challenges for sustainable urban development. The reasons are manifold. Preventive measures are put on the back burner, while reactive measures, siloed governance approaches and power struggles are daily business, resulting in ineffective governance. The crisis is hitting the most vulnerable urban popul

When interpreting a natural language argument that generalizes over a contextually relevant category, audiences are likely to activate the category prototype and transfer its characteristics onto category instances. A generalized argument can thus appear more (respectively less) persuasive than one mentioning a specific category instance, provided the argument’s claim is more (less) warranted for