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In this work, mathematical models have been developed describing drug release from film-coated reservoir systems as well as drug release and polymer dissolution from swelling and dissolving polymer tablets. The model derivation of both systems is based on a mechanistic approach. The model describing drug release from reservoir systems, i.e. from single, film-coated pellets, was validated against e

This dissertation examines the correspondence of the 18th-century German authors Anna Louisa Karsch and Johann Wilhelm Ludwig Gleim. The main emphasis of the present study is to demonstrate how readings of Karsch's and Gleim's correspondence shed light on epistolary culture. Particular attention is paid to the notion of epistolary culture as a relatively unrestrained ?experimental setting? for bou

Many anthropogenically-produced or beneficiated materials contained in “end-of-life” products retain a great proportion of the invested manufacturing work when discarded. Very few such materials are reconstituted and applied in new products at the same material inherent quality level as in their first lifetime – a process known as “closed-loop recycling”. In general, industrial society maintains a

The present study deals with different aspects of the mitsvat mezuzah in Rabbinic literature from the first to the sixteenth centuries, with some emphasis on the medieval sources. Through a charting of statements regarding the mezuzah as an object, and the mitsvat mezuzah and its fulfilment, an overview is given of the development of the mezuzah and the perception of it

In software engineering, the quality of software and in particular the software reliability has to be controlled and improved. Hence there is a need for measuring and controlling the number and appearance of software faults and failures. This thesis presents models for estimation of residual faults after inspections and a model for usage specifications which enables estimation of operational failu

The dissertation shows two different means or directions for creating civic participation: the collective and the individual way. The collective way is characterized by the citizen's ability to participate only through elected representatives while the individual way makes it possible for inhabitants to participate face to face with politicians and local civil servants. Two different theories hav

In the present work a dynamic model library of components for process lines was developed. The analysis addressed characteristic aspects of liquid food process lines, and new models were developed for fluid transitions, dispersion, mixing zones and first-order chemical reactions in pipes and heat exchangers. The computational efficiency and accuracy of the models were analysed. It was demonstrated

Size, as expressed by molar mass, radius of gyration or hydrodynamic radius, for example, is a fundamental parameter of polymers in solution. Thus, there is a strong need for the characterisation of both the size and shape of polymers, particularly of those utilised in various industrial applications. In this thesis, a relatively novel technique, asymmetrical flow field-flow fractionation (flow FF

As a co-author of the Formula of Concord, Martin Chemnitz (1522-86) codified the sola scriptura principle of the Reformation, that the prophetic and apostolic Scriptures are the only rule for all Church doctrine. This principle is clearly expressed in Chemnitz' own theological treatises as well, but in his argumentation one is also confronted with an astonishing number of quotations from the Churc

In the beginning of the Common Era, a number of religious texts were written recounting heavenly journey adventures. These narratives have come to constitute a recurring theme in research regarding ancient religions. Round Trips to Heaven features several early Jewish and Christian heavenly journey texts. Most of them are included in the apocalyptic literature. During the earlier research, the he

Radiotherapy is one of the major tools for treating cancer. Through research and technical development radiotherapy is becoming more advanced with new treatment techniques emerging. In the work presented in this thesis, well-known methods have been used, or modified for use, and new methods have been introduced in order to optimise the clinical use of an advanced radiotherapy treatment technique,

Groundwater depletion in arid and semiarid areas is of increasing concern. Increasing water demand due to increasing population and climate change impacts have intensified the water shortage problems and put further stress especially on groundwater. Water harvesting techniques have been traditional solutions to water scarcity problems in the arid and semiarid Middle East for thousands of years. Th

In Northern Ireland and South Africa obstacles to reconciliation were found in these elements of a “moral landscape”: – Experiences of trauma, separation and inequalities, – Divergent views of the conflict and of “the other”, – Opposing identifications and loyalties, – Norms for interaction, – Contestant interpretations of values such as “peace” and “justice”. This study describes how these obstac

In international commerce, various taxes and charges are levied on commodities; besides, goods may be subject to import and export restrictions. However, free-trade agreements may stipulate that some goods can be imported and exported free of charge. The regulations pertaining to different types of merchandise are reflected in the customs tariff of a state or customs union. The application of many

In 2005 two research groups independently reported the isolation of a series of structurally intriguing C-19 terpenolides from the plants Thapsia transtagana and Thapsia garganica. The compounds were shown to be potent inhibitors of the sarco/endoplasmic reticulum Ca2+-ATPases. The interesting biological properties and the unique structural characteristics of the transtaganolides/basiliolides (the

Coagulation factor IX (FIX) is a vitamin K-dependent serine protease zymogen that circulates in plasma. Defects in FIX cause the bleeding disorder hemophilia B. FIX contains a Gla module, two Epidermal Growth Factor (EGF) -like modules and a serine protease region. In this thesis, studies have been performed on the N-terminal EGF module, which binds one Ca2+. — The present results show that bindin

A broad, distinctive material presentation is done, which is linked to some variables of psychological value, stating a research for the authenticity of Garborg in viewing him as well a symptom bearer as a symptom solver. An introduction to Garborg is meant to be an invitation, especially to those who are not so well acquainted with him as a person and a writer. Out from a period of about 110 year

The intense debate on continuity in child grammars has largely focused on the existence of Functional Categories (FCs) in early grammars despite differences in language use with adults (e.g., omissions, word order errors, lack of case marking). Simplified, the major theoretical explanations for these properties range from Maturational accounts (Radford 1990 and later) claiming an initial absence o