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We sought to identify novel pharmacogenetic markers associated with cardiovascular outcomes in patients with hypertension on antihypertensive therapy. We genotyped a 1:4 case:control cohort (n=1345) on the Illumina HumanCVD Beadchip from the INternational VErapamil SR-Trandolapril STudy (INVEST), where participants were randomized to a -blocker strategy or a calcium channel blocker strategy. Genom

Background Problematic Internet use is characterized by excessive use of online platforms that can result in social isolation, family problems, psychological distress, and even suicide. Problematic Internet use has been associated with cannabis use disorder, however knowledge on the adult population remains limited. In Quebec, cannabis use has significatively increased since 2018, and it is associ

Aquaporin-0 (AQP0) is the main water channel in the mammalian lens and is involved in accommodation and maintaining lens transparency. AQP0 binds the Ca2+-sensing protein calmodulin (CaM) and this interaction is believed to gate its water permeability by closing the water-conducting pore. Here, we express recombinant and functional human AQP0 in Pichia pastoris and investigate how phosphorylation

Over the last 10,000 y, humans have manipulated fallow deer populations with varying outcomes. Persian fallow deer (Dama mesopotamica) are now endangered. European fallow deer (Dama dama) are globally widespread and are simultaneously considered wild, domestic, endangered, invasive and are even the national animal of Barbuda and Antigua. Despite their close association with people, there is no con

Background: Patients with cyanotic congenital heart disease (CCHD) may have a low burden of atherosclerosis. Endothelial dysfunction is an early stage of atherosclerosis and endothelial function is previously studied in smaller CCHD groups with different techniques and variable results. We aimed to examine endothelial function and carotid atherosclerosis in a larger group of CCHD patients. Methods

The neurodegenerative Huntington's disease (HD) is caused by a polyglutamine (polyQ) amplification in the huntingtin protein (HTT). Currently there is no effective therapy available for HD; however, several efforts are directed to develop and optimize HTT-lowering methods to improve HD phenotypes. To validate these approaches, there is an immediate need for reliable, sensitive, and easily accessib

The 2006 rent reform in Sweden enabled rent in newly-built rental apartments to be based on construction costs rather than objective characteristics that are considered relevant to the tenant, as with the ordinary rental system. This new type, presumption rent, is presumed to be fair during a period of ten years (subsequently prolonged to 15 years) and cannot, during this time, be challenged by th

Terminstider läsåret 2023/24 Beslut Sida 1 av 3 Student och utbildning Diarienummer U 2022/287 2022-06-20 Reviderad: 2022-12-01 Terminstider läsåret 2023/24 För läsåret 2023/24 gäller följande terminstider: Höstterminen 2023 pågår från och med måndagen den 28 augusti 2023 till och med söndagen den 14 januari 2024. Vårterminen 2024 pågår från och med måndagen 15 januari 2024 till och med söndagen d

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2022-12/Terminstider-lasaret-2023-24.pdf - 2025-12-25

The first of July 2018, the Swedish sexual cime act on rape was change. The previous crime prerequisites violence and threat were removed. The prerequisite was replaced by the fact that the penalty limit is that one party "did not participated freely". In the media, the law has been named the law of consent. While the law was introduced, criticism of new law was put forward by several ac

Acquittals in cases of child sexual abuse have repeatedly been criticized in the social debate. Not least when it comes to perpetrators not being considered having reason to assume that a child was under age, although the child being as young as 11-12 years old. The critique has been legitimate when regarding the problems before the change of the statutory regulation on July 1st, 2018. The efficie

Hemliga tvångsmedel är av stor betydelse för framgångsrik brottsbekämpning i samhället. Samtidigt innebär det en inskränkning av den enskildes rätt till privat- och familjeliv. Detta arbete analyserar om det är möjligt för brottsbekämpande myndigheter att skapa trygghet i den demokratiska rättsstaten genom mer effektiv brottsuppklaring med hjälp av hemliga tvångsmedel, utan att samtidigt kränka deSecret surveillance methods are of great importance for successful law enforcement in today’s society, however, the benefits for the crime fighting authorities can be at the expense of the individual’s rights to privacy. The object of this thesis is to analyze whether it is possible for law enforcement agencies to create a safe community, in a democratic constitutional state, through the use of se

The adoption of a so-called consent-based rape law has been heavily debated for over two decades. On July 1st, 2018 a rape clause based on voluntarism was introduced. As a result, the rape regulation was extended in such a way that it no longer requires force, or exploitation of a particular vulnerable situa-tion, for criminal liability to occur. The purpose of the new rape regulation is to protec

Fankulturen har idag kunnat ta plats på en större arena tack vare internet i form av fan communities och fansajter. Detta har lett till att fansen idag har enklare tillgång till andra fans, interaktion och livsstilsbildande. Gemenskap är ett socialt fenomen som är en intressant och en central aspekt att undersöka på dessa digitala plattformar, eftersom gemenskapsaspekten för människan är relativt

The new Market Abuse Regulation (the MAR) entered into force on July 3rd 2016. The MAR is the latest step in a long-running regulatory process from the EU concerning the securities market, and as it entered into force it replaced the previously applicable Market Abuse Directive (the MAD). The MAR contains a few novelties, which can appear alien to Swedish operators at the securities market. For ex

In 2009, it was estimated that around 70 000 young men’s and women’s choice when it came to marriage and choice of partner in Sweden was limited or conditional. The Government concluded that the legislation did not effectively fight the occurrence of forced marriage and child marriage, and therefore presented a proposition for civil and criminal law changes. The law changes came into force July 1s

Title: IPO’s: a post festum - Can post-IPO stock performance be predicted? Seminar date: January 14th, 2016 Course: FEKH89, Degree Project in Corporate Finance, Undergraduate level, Business Administration, 15 ECTS Authors: Simon Bengtsson, Julia Colven, Jonathan Karlsson, Alexander Vitols Advisor: Göran Andersson Key words: Initial Public Offerings, Company age, Private equity, Founder, Insid

Abstract Title The eternal pursuit of the ideal A study about the interaction between the female ideal, consumers identity projects and personal brands on Instagram Seminar date 2016-06-02 Subject/course FEKH29 – Bachelor’s thesis in Marketing, 15 ECTS Authors Emma Bogren, Annika Eriksson and Julia Sjöberg Advisor Clara Gustafsson Key words Identity, Ideal, Culture, Personal brands Issue Ind

The EU Market Abuse Regulation, MAR, entered into force in July 2016 and is a central framework in the field of stock-market law. The regulation provides a uniform definition of the concept of inside information that has a significant role in both the application and understanding of several provisions in the regulation. These aim to create transparency in the market, as well as to combat various