Filetype
The balance between self-renewal and differentiation is crucial for the maintenance of hematopoietic stem cells (HSCs). Whereas numerous gene regulatory factors have been shown to control HSC self-renewal or drive their differentiation, we have relatively few insights into transcription factors that serve to restrict HSC differentiation. In the present work, we identify ETS (E-twenty-six)-related
Mucosal surfaces of the reproductive tract as well as their secretions have important roles in preventing sexual transmission of HIV-1. In the current study, the majority of the intrinsic anti-HIV-1 activity of human seminal plasma (SP) was determined to reside in the cationic polypeptide fraction. Antiviral assays utilizing luciferase reporter cells and lymphocytic cells revealed the ability of w
One of the major roles of seminal plasma is to provide antimicrobial protection for the spermatozoa in the female reproductive tract. We found that the bactericidal activity of seminal plasma was highest after resolution of the seminal clot and that this antibacterial activity subsequently became greatly diminished. The antibacterial activity was derived from peptides generated by fragmentation of
Does sertraline provide symptomatic relief for chronic breathlessness in people with advanced disease whose underlying cause(s) are optimally treated?223 participants with chronic breathlessness (modified Medical Research Council breathlessness scale ≥2) who had optimal treatment of underlying cause(s) were randomised 1:1 to sertraline 25-100 mg (titrated upwards over 9 days) or placebo for 4 week
After the latest Permian mass extinction event, microbial mats filled the ecological niche previously occupied by metazoan reefs, resulting in widespread microbialites. This study focuses on the lipid biomarker (molecular fossil) and invertebrate fossil records from Neotethyan platform margin sections to understand microbial-metazoan bioherm formation. Here, we find that early Griesbachian thrombo
The transcription factor Sox4 has been proposed to underlie the increased type 2 diabetes risk linked to an intronic single nucleotide polymorphism in CDKAL1. In a mouse model expressing a mutant form of Sox4, glucose-induced insulin secretion is reduced by 40% despite normal intracellular Ca2+ signaling and depolarization-evoked exocytosis. This paradox is explained by a fourfold increase in kiss
In the course of 2000s, the region of Campania in southern Italy and its capital city Naples became global icons of waste mismanagement after the images of piles of rubbish occluding their urban areas hit the headlines. Conventional explanations, in Italy and elsewhere, pointed to administrative failure, cultural backwardness and mafia infiltration as the main causes of waste mishandling. In the s
Importance: Novel plasma biomarkers, especially phosphorylated tau (p-tau), can detect brain tau aggregates in Alzheimer disease. Objective: To determine which plasma biomarker combinations can accurately detect tau pathological brain changes in Down syndrome (DS). Design, Setting, and Participants: The cross-sectional, multicenter Alzheimer's Biomarker Consortium-Down Syndrome study included adul
Previous research suggests a pattern of gaze avoidance in East Asian compared with Western cultures. Yet, recent eye-tracking studies of face-to-face conversation do not corroborate this. More generally, differences in nonverbal communication and analytic versus holistic strategies have been described between East Asian and Western cultures. Using wearable eye-tracking technology and an automated
Uppsatsen behandlar det genomgående motivet av maktkamper i August Strindbergs dramatik. Konflikten är en essentiell ingrediens i praktiskt taget all berättande men Strindberg går ofta längre i sina dramer. Huvudpersonen kämpar mot religionen, andra människor eller sig själv och kampen är en strävan efter makt över motståndaren eller vad den andre parten representerar. Uppsatsen analyser ett anta
Membrane proteins (MPs) constitute a large fraction of the proteome, but exhibit physicochemical characteristics that impose challenges for successful sample production crucial for subsequent biophysical studies. In particular, MPs have to be extracted from the membranes in a stable form. Reconstitution into detergent micelles represents the most common procedure in recovering MPs for subsequent a
Att köpa sexuella tjänster har varit brottsligt i Sverige sedan 1999. Även om kriminaliseringen i förarbetena delvis motiverades med att prostitution är skadligt för individerna som befinner sig i situationen så är det inte, åtminstone inte tydligt, ett brott mot person. Samtidigt finns det personer med erfarenhet av att sälja sex som vittnar om utsatthet och övergrepp inom prostitutionen, något sBuying sexual services has been illegal in Sweden since 1999. Although the criminalization in the preparatory work was partly motivated by the fact that prostitution is harmful to the individuals who are in the situation, it is not, at least not clear, a crime against an individual. At the same time, there are people with experience of selling sex that tells about their experiences, showing that a
Abstrakt Bakgrund: Ambulanstransporter av intensivvårdspatienter kan vara nödvändiga för att genomföra undersökningar eller behandlingar på ett annat sjukhus. Transporten ska vara så säker som möjligt och inte öka riskerna för patienten. Syfte: Studiens syfte var att kartlägga de interhospitala transporter som utfördes av Region Skånes Intensivvårdsambulans mellan 2010-2013. Metod: Retrospektiv,
The purpose of this essay has been to investigate how the latest years of effectiveness in social politics has changed the social services and their work with starting point in the changed rules for social insurance in form of sickness leave. The new rules which emerged in July 2008 have meant that sickness benefits is limited to one year. This occurred in the time when labour market policy become
The 2006 rent reform in Sweden enabled rent in newly-built rental apartments to be based on construction costs rather than objective characteristics that are considered relevant to the tenant, as with the ordinary rental system. This new type, presumption rent, is presumed to be fair during a period of ten years (subsequently prolonged to 15 years) and cannot, during this time, be challenged by th
Title: From buzzword to truth? Seminar date: 2014-06-05 Course: FEKH29, Bahelor Thesis in Business Administration, specialization in marketing, Undergraduate level, 15ECTS Authors: Jeanna Lundberg and Julia Undin Advisor: Jon Bertilsson Key words: buzzword, fad, the Swedish advertising business, content marketing, attachment Purpose: Improving prior knowledge of how advertising agencies in S
Sveriges medlemskap i EU medför att förordningar och direktiv måste implementeras. Sverige har vid flertalet tillfällen mottagit kritik både från EUkommissionen och via en anmälan från TCO, för bristande tillämpning i nationell lagstiftning vad gäller visstidsdirektivet. Kommissonen anser att Sverige inte uppfyller direktivets krav något TCO instämmer i. Svenskt Näringsliv och svenska staten bifal
I Socialstyrelsens rapport ”Vårdnadsöverflyttning i samband med våld i familjen” som publicerades 2013 framkom att det i många fall tog lång tid för vårdnaden att flyttas från en förälder som dödat den andra föräldern. Detta föranledde regeringen att utreda möjliga lösningar för att vårdnadsöverflyttningen i sådana fall skulle kunna göras snabbare, och resulterade i införandet av 6 kap 10 d § föräThe National Board of Health and Welfare presented a report in 2013 regarding custody transfers relating to violence in the family. The report showed that it took a long time for a custody transfer to occur in cases when a parent had killed the other parent. This led the government to investigate possible solutions to make such custody transfers happen faster, which resulted in chapter 6 section 1
Title: The Generation Challenge – a Quantitative Study of Generational Market Segmentation within the Field of Digital Marketing Seminar Date: June 4th, 2015 Course: FEKH29 Business Administration: Degree Project in Marketing, Undergraduate Level, 15 ECTS Authors: Agata Anna Gornik, Eric Ingelström, and Julia Kulle Advisor: Clara Gustafsson Keywords: Generational Market Segmentation, Baby Bo
