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The balance between self-renewal and differentiation is crucial for the maintenance of hematopoietic stem cells (HSCs). Whereas numerous gene regulatory factors have been shown to control HSC self-renewal or drive their differentiation, we have relatively few insights into transcription factors that serve to restrict HSC differentiation. In the present work, we identify ETS (E-twenty-six)-related
Does sertraline provide symptomatic relief for chronic breathlessness in people with advanced disease whose underlying cause(s) are optimally treated?223 participants with chronic breathlessness (modified Medical Research Council breathlessness scale ≥2) who had optimal treatment of underlying cause(s) were randomised 1:1 to sertraline 25-100 mg (titrated upwards over 9 days) or placebo for 4 week
After the latest Permian mass extinction event, microbial mats filled the ecological niche previously occupied by metazoan reefs, resulting in widespread microbialites. This study focuses on the lipid biomarker (molecular fossil) and invertebrate fossil records from Neotethyan platform margin sections to understand microbial-metazoan bioherm formation. Here, we find that early Griesbachian thrombo
The land-atmosphere exchange of methane (CH4) and carbon dioxide (CO2) in a high-Arctic wet tundra ecosystem (Rylek ae rene) in Zackenberg, north-eastern Greenland, was studied over the full growing season and until early winter in 2008 and from before snow melt until early winter in 2009. The eddy covariance technique was used to estimate CO2 fluxes and a combination of the gradient and eddy cova
In the course of 2000s, the region of Campania in southern Italy and its capital city Naples became global icons of waste mismanagement after the images of piles of rubbish occluding their urban areas hit the headlines. Conventional explanations, in Italy and elsewhere, pointed to administrative failure, cultural backwardness and mafia infiltration as the main causes of waste mishandling. In the s
Letting a child witness certain criminal acts being committed between relatives to the child has been criminalized since July 1, 2021. The witnessing requirement constitutes a necessary prerequisite for criminal liability and implies that the child must have seen or heard the criminal act being committed. During the legislative process, it was noted that the requirement could give rise to certain
The transcription factor Sox4 has been proposed to underlie the increased type 2 diabetes risk linked to an intronic single nucleotide polymorphism in CDKAL1. In a mouse model expressing a mutant form of Sox4, glucose-induced insulin secretion is reduced by 40% despite normal intracellular Ca2+ signaling and depolarization-evoked exocytosis. This paradox is explained by a fourfold increase in kiss
Previous research suggests a pattern of gaze avoidance in East Asian compared with Western cultures. Yet, recent eye-tracking studies of face-to-face conversation do not corroborate this. More generally, differences in nonverbal communication and analytic versus holistic strategies have been described between East Asian and Western cultures. Using wearable eye-tracking technology and an automated
Title Still on sale? – A study on the theories about the abnormal return of IPO:s Seminar date: 12/1 2017 Course: FEKH89, Corporate Finance Degree Project, Undergraduate level, Business Administration, 15 ECTS Authors: Julia Borrebaeck, Viktor Lloyd, Jesper Vamborg, Advisor/s: Tore Eriksson Key words: IPO:s, Nasdaq OMX Stockholm, underpricing, long term underperformance, comparative research Purpo
Engelsk sammanfattning Due to the entry into force for a decriminalization regarding homosexuality in July 1944, homosexual activities were not considered as something criminal anymore. The struggle towards a more equal society did not end there. It took until 1979 before homosexuality was removed from the National Board of Health and Welfare (Socialstyrelsens) register of illnesses. Today, homos
Den 7 oktober 2020 presenterades utredningen Ett särskilt hedersbrott, SOU 2020:57, med förslaget att låta brott med hedersmotiv utgöra en egen brottsrubricering. För att utreda om det vore befogat att införa lagförslaget i brottsbalken analyseras det utifrån några utvalda principer och teorier för kriminalisering. Trots att heder är ett problematiskt och svårdefinierat begrepp kan några karaktäOn October 7, 2020 the investigation Ett särskilt hedersbrott, SOU 2020:57, was presented, with a proposal to let crimes with honor motives constitute a specific criminal provision. In order to investigate if it would be justified to introduce in the Penal Code, the proposal will be analyzed on the basis of some selected principles and theories for criminalization. Although honor is a problemati
On the 1 of July 2002 the Directive 98/71/EC of the European Parliament and of the Council on the legal protection of designs was implemented in the Swedish Design Protection Act (1970:485). The harmonization of the design rights within the EU brought an exemption provision contained in section 4 a § 1 pc. 1p. in the Design Protection Act (1970: 485), which statutes that a design right must not su
On July the 20th 2017 the Swedish government announced a proposition about new rules regarding the taxation of companies. The proposition contained a general interest deduction limitation rule. At the same time, the government proposed that the interest deduction limitation rules in force at the time of writing should be kept with some changes. The purpose of this study is to examine which possibi
Under de senaste femtio åren har de europeiska kapitalmarknaderna blivit allt mer integrerade. För att garantera allmänhetens förtroende, för att förhindra framtida finanskriser och för att nå den ekonomiska effektiviteten på marknaden, är det viktigt att det finns harmoniserade förbud mot marknadsmissbruk. En vanlig form av marknadsmissbruk är handel med insiderinformation, som kan leda till stoDuring the last fifty years, the European capital markets have become increasingly integrated. In order to ensure public confidence, to prevent future financial crises and to reach economic efficiency on the market, it is of importance that there are harmonised prohibitions against market abuse. A common form of market abuse on the European market is trading with inside information, which can lea
Den svenska straffrätten har under det senaste århundradet genomgått en mängd förändringar. Allt som oftast har påföljdssystemet varit utformad efter de för tillfället förhärskande bestraffningsteorierna. Det finns en lång tradition av särbehandling av unga lagöverträdare i Sverige och till viss del så tas hänsyn till andra intressen när det gäller ungdomar. Denna framställning ska besvara frågornSwedish penal law has undergone many changes over the last centuries. The sanction system has most often been modelled on penalization theories dominant at the time. Sweden has a long tradition of special treatment of young offenders, and other interest are to some extent taken into consideration when it comes to juvenile offenders compared to adults. This essay will answer the questions of which
Många groddjur har minskande populationstrender både lokalt och globalt. Inventeringar av groddjur är en viktig del av arbetet för att få mer information om deras utbredning för att kunna skydda groddjuren och deras miljöer. Detta kan ha positiva effekter även på andra djur och växter eftersom groddjur är bra indikatorer på rika miljöer. Genom sitt vattenupptag via huden är groddjuren extremt käns
Syftet med denna examensuppsats är att utreda en rad arbetsrättsliga rättigheter och skyldigheter, som kan uppstå vid distansarbete. De områden jag har valt att fokusera på är arbetsbristuppsägningar och turordning, arbetsledningsrätt, arbetsskyldighet och arbetstid samt arbetsmiljö. Två utgångspunkter för arbetet har varit distansarbetsutredningen, SOU 1998:115, och distansarbetsavtalet, som trädMy thesis aims to assess different problems in employment law when dealing with teleworkers. I have chosen to focus on redundancy dismissals and seniority right, the managerial prerogative, the duty to work, working hours and working environment. Two starting points are the Government Inquiry Report on telework, SOU 1998:115, and the telework agreement, which entered into force in July 2002 betwee
