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This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To determine the benefits and harms associated with weight loss in overweight individuals with knee or hip osteoarthritis in terms of pain, physical function, quality of life, and safety. Further we will have an explicit focus on quality of the weight loss intervention (including magnitude and intensity) (Herbe
Single nucleotide polymorphisms (SNPs) in various genes have been shown to associate with COPD, suggesting a role in disease pathogenesis. Sulfatase modifying factor (SUMF1) is a key modifier in connective tissue remodelling, and we have shown previously that several SNPs in SUMF1 are associated with COPD. The aim of this study was to investigate the association between SUMF1 SNPs and advanced l
This dissertation proposes a theory concerning China’s “Fragmented Power” in its foreign policy pursuits by analyzing the reception of the “Belt and Road” Initiative in Sri Lanka. The initiative has sparked intense debates and counteractions on the global stage and has become synonymous with Xi Jinping’s assertive approach to foreign policy. However, many aspects of the initiative’s goals, impleme
Mars science fiction (SF) has interacted with Mars science ever since the advent of modern science, and has largely influenced public perceptions of the red planet and its exploration. In this chapter, it is argued that it has not only shaped numerous (mis)conceptions about the possibilities of indigenous Martian life, eventual human settlement and its challenges, but that it also has a large outr
Diabetes is a bihormonal disorder resulting from combined insulin and glucagon secretion defects. Mice lacking fumarase (Fh1) in their β cells (Fh1βKO mice) develop progressive hyperglycemia and dysregulated glucagon secretion similar to that seen in diabetic patients (too much at high glucose and too little at low glucose). The glucagon secretion defects are corrected by low concentrations of tol
Chronic obstructive pulmonary disease (COPD) is a leading cause of death world-wide. Recently, we showed that COPD is associated with gene polymorphisms in SUMF1, a master regulator of sulfatases. Sulfatases are involved in extracellular matrix remodeling and activated by SUMF1, but their role in the lung is poorly described. We aimed to examine how sulfatases are affected in the airways of patien
Obesity is a major threat to global health and metabolically associated with glycerol homeostasis. Here we demonstrate that in human adipocytes, the decreased pH observed during lipolysis (fat burning) correlates with increased glycerol release and stimulation of aquaglyceroporin AQP10. The crystal structure of human AQP10 determined at 2.3 Å resolution unveils the molecular basis for pH modulatio
Background: The Bethesda system for cytopathology (TBSRTC) is a 6-tier diagnostic framework developed to standardize thyroid cytopathology reporting. The aim of this study was to determine the risk of malignancy (ROM) for each Bethesda category. Methods: Thyroidectomy-related data from 314 facilities in 22 countries were entered into the following outcome registries: CESQIP (North America), Eurocr
Subjective reports of sleep disturbance are a common feature of Huntington's disease (HD); however, there is limited research investigating the relationship between sleep problems with changes in brain and behaviour. This study aimed to investigate whether subjective reports of sleep problems in HD are associated with brain volume, neurocognitive decline, and neuropsychiatric symptoms. This retros
Dysfunctional microRNA (miRNA) networks contribute to inappropriate responses following pathological stress and are the underlying cause of several disease conditions. In pancreatic beta cells, miRNAs have been largely unstudied and little is known about how specific miRNAs regulate glucose-stimulated insulin secretion (GSIS) or impact the adaptation of beta cell function to metabolic stress. In t
Ternary semiconductor nanowire arrays enable scalable fabrication of nano-optoelectronic devices with tunable bandgap. However, the lack of insight into the effects of the incorporation of Vy element results in lack of control on the growth of ternary III-V1-yVy nanowires and hinders the development of high-performance nanowire devices based on such ternaries. Here, we report on the origins of Sb-
OBJECTIVE-We report here genotyping data and type 1 diabetes association analyses for HLA class I loci (A, B, and C) on 1,753 multiplex pedigrees from the Type 1 Diabetes Genetics Consortium (T1DGC), a large international collaborative study. RESEARCH DESIGN AND METHODS-Complete eight-locus HLA genotyping data were generated. Expected patient class I (HLA-A, -B, and -C) allele frequencies were cal
Purpose: To investigate how revealing the official secrets in different industries influence consumer trust. Methodology: Primary data were collected through a quantitative consumer survey measuring the impact of revealing an official secret on trust. This was complemented by secondary case analyses of Polestar and Kérastase, supported by relevant literature and industry sources to contextualize
OBJECTIVE: This study utilized the evidence-gap map method and critically examined the scope, methodologies, and focus of the studies that investigated the influence of the built environment on inpatient healthcare settings over a decade (2010-2021).METHODS: We conducted a systematic review per the preferred reporting items for systematic reviews and meta-analyses guidelines and surveyed 406 artic
Glacial-interglacial variations in CO 2 and methane in polar ice cores have been attributed, in part, to changes in global wetland extent, but the wetland distribution before the Last Glacial Maximum (LGM, 21 ka to 18 ka) remains virtually unknown. We present a study of global peatland extent and carbon (C) stocks through the last glacial cycle (130 ka to present) using a newly compiled database
The 2006 rent reform in Sweden enabled rent in newly-built rental apartments to be based on construction costs rather than objective characteristics that are considered relevant to the tenant, as with the ordinary rental system. This new type, presumption rent, is presumed to be fair during a period of ten years (subsequently prolonged to 15 years) and cannot, during this time, be challenged by th
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https://www.sol.lu.se/media/utbildning/dokument/kurser/SVEF26/20191/Valkomstbrev_S19_Akademiskt_skrivande_2.pdf - 2025-12-21
The World Turned Upside Down: art and ethics in the rise of the ‘Stone Age SouthValbar kurs på BFA nivå/Optional BFA-level course Lärare/Teacher: Sarat Maharaj and guest lecturers Kursbeskrivning”Världen upp och ner”: Konst och etik i den begynnande södra stenåldern Dagens flyktingströmmar verkar överlag röra sig ”norrut” – till och med på södra halvklotet där man söker sig mot den andra polen. ”
https://www.khm.lu.se/world-turned-upside-down-art-and-ethics-rise-stone-age-south - 2025-12-21
The World Turned Upside Down: art and ethics in the rise of the ‘Stone Age SouthValbar kurs på BFA nivå/Optional BFA-level course Kursbeskrivning (english below): Dagens flyktingströmmar verkar överlag röra sig ”norrut” – till och med på södra halvklotet där man söker sig mot den andra polen. ”Syd” har alltmer blivit liktydigt med ”underutveckling och kris”. Men det har också vuxit fram idéer om
https://www.khm.lu.se/world-turned-upside-down-art-and-ethics-rise-stone-age-south-0 - 2025-12-21
