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Your search for "julie" yielded 4782 hits

Correlating the Bethesda System for Reporting Thyroid Cytopathology with Histology and Extent of Surgery : A Review of 21,746 Patients from Four Endocrine Surgery Registries Across Two Continents

Background: The Bethesda system for cytopathology (TBSRTC) is a 6-tier diagnostic framework developed to standardize thyroid cytopathology reporting. The aim of this study was to determine the risk of malignancy (ROM) for each Bethesda category. Methods: Thyroidectomy-related data from 314 facilities in 22 countries were entered into the following outcome registries: CESQIP (North America), Eurocr

Human sickness detection is not dependent on cultural experience

Animals across phyla can detect early cues of infection in conspecifics, thereby reducing risk of contamination. It is unknown, however, if humans can detect cues of sickness in people belonging to communities with whom they have limited or no experience. To test this, we presented Western faces photographed two hours after the experimental induction of an acute immune response to one Western and

Single-nucleotide polymorphisms in the sulfatase-modifying factor 1 gene are associated with lung function and COPD

Single nucleotide polymorphisms (SNPs) in various genes have been shown to associate with COPD, suggesting a role in disease pathogenesis. Sulfatase modifying factor (SUMF1) is a key modifier in connective tissue remodelling, and we have shown previously that several SNPs in SUMF1 are associated with COPD. The aim of this study was to investigate the association between SUMF1 SNPs and advanced l

MicroRNA-7a regulates pancreatic beta cell function

Dysfunctional microRNA (miRNA) networks contribute to inappropriate responses following pathological stress and are the underlying cause of several disease conditions. In pancreatic beta cells, miRNAs have been largely unstudied and little is known about how specific miRNAs regulate glucose-stimulated insulin secretion (GSIS) or impact the adaptation of beta cell function to metabolic stress. In t

Crystallization of Human Aquaglyceroporins for Neutron Diffraction Studies

Aquaglyceroporins are channels that facilitate the flux of glycerol and water across lipid bilayers. Although structural information is available for several aquaglyceroporins, the details of how water and glycerol selectivity are maintained and how protons are excluded remain elusive. An approach to obtaining data on the hydrogen atom positions is to apply neutron macromolecular crystallography.

A Systematic Review of Research Gaps in the Built Environment of Inpatient Healthcare Settings

OBJECTIVE: This study utilized the evidence-gap map method and critically examined the scope, methodologies, and focus of the studies that investigated the influence of the built environment on inpatient healthcare settings over a decade (2010-2021).METHODS: We conducted a systematic review per the preferred reporting items for systematic reviews and meta-analyses guidelines and surveyed 406 artic

The applicability of the WHO classification in paediatric AML. A NOPHO-AML study

The World Health Organization (WHO) classification of myeloid leukaemia was revised in 2008. It incorporates newly recognized entities and emphasizes the pivotal role of cytogenetic abnormalities. The aim of this study was to evaluate the usability of the WHO classification when applied to a large population-based paediatric acute myeloid leukaemia (AML) cohort. We included children diagnosed with

Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

Cardiac fibrosis, associated with a decreased extent of microvasculature and with disruption of normal myocardial structures, results from excessive deposition of extracellular matrix, which is mediated by the recruitment of fibroblasts. The source of these fibroblasts is unclear and specific anti-fibrotic therapies are not currently available. Here we show that cardiac fibrosis is associated with

Mars in Science Fiction and Our Perceptions of the Red Planet

Mars science fiction (SF) has interacted with Mars science ever since the advent of modern science, and has largely influenced public perceptions of the red planet and its exploration. In this chapter, it is argued that it has not only shaped numerous (mis)conceptions about the possibilities of indigenous Martian life, eventual human settlement and its challenges, but that it also has a large outr

Widespread global peatland establishment and persistence over the last 130,000 y

Glacial-interglacial variations in CO 2 and methane in polar ice cores have been attributed, in part, to changes in global wetland extent, but the wetland distribution before the Last Glacial Maximum (LGM, 21 ka to 18 ka) remains virtually unknown. We present a study of global peatland extent and carbon (C) stocks through the last glacial cycle (130 ka to present) using a newly compiled database

Weight loss for overweight patients with knee or hip osteoarthritis

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To determine the benefits and harms associated with weight loss in overweight individuals with knee or hip osteoarthritis in terms of pain, physical function, quality of life, and safety. Further we will have an explicit focus on quality of the weight loss intervention (including magnitude and intensity) (Herbe

Human adipose glycerol flux is regulated by a pH gate in AQP10

Obesity is a major threat to global health and metabolically associated with glycerol homeostasis. Here we demonstrate that in human adipocytes, the decreased pH observed during lipolysis (fat burning) correlates with increased glycerol release and stimulation of aquaglyceroporin AQP10. The crystal structure of human AQP10 determined at 2.3 Å resolution unveils the molecular basis for pH modulatio

Expression, activity and localization of lysosomal sulfatases in Chronic Obstructive Pulmonary Disease

Chronic obstructive pulmonary disease (COPD) is a leading cause of death world-wide. Recently, we showed that COPD is associated with gene polymorphisms in SUMF1, a master regulator of sulfatases. Sulfatases are involved in extracellular matrix remodeling and activated by SUMF1, but their role in the lung is poorly described. We aimed to examine how sulfatases are affected in the airways of patien

Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production

Diabetes is a bihormonal disorder resulting from combined insulin and glucagon secretion defects. Mice lacking fumarase (Fh1) in their β cells (Fh1βKO mice) develop progressive hyperglycemia and dysregulated glucagon secretion similar to that seen in diabetic patients (too much at high glucose and too little at low glucose). The glucagon secretion defects are corrected by low concentrations of tol

Subjective sleep problems in Huntington's disease : A pilot investigation of the relationship to brain structure, neurocognitive, and neuropsychiatric function

Subjective reports of sleep disturbance are a common feature of Huntington's disease (HD); however, there is limited research investigating the relationship between sleep problems with changes in brain and behaviour. This study aimed to investigate whether subjective reports of sleep problems in HD are associated with brain volume, neurocognitive decline, and neuropsychiatric symptoms. This retros

Plant-soil-herbivore interactions in a high Arctic wetland - Feedbacks to the carbon cycle

Popular Abstract in Danish Omkring halvdelen af den globale kulstof mængde som findes i jorden, er lagret i de arktiske jorde. Arktiske jorde har været anset for at være vigtige kulstof reservoirs de sidste 10.000 år, hvor der bliver optaget mere kulstof end der frigives. Dette skyldes blandt andet den langsomme omsætning af organiske materiale på grund af de kolde forhold, men også de store mængdArctic ecosystems hold massive amounts of the global carbon in their soils and are of great importance for the global terrestrial exchange of greenhouse gases to the atmosphere. The arctic region has in general been acting as a C sink for the past 10000 years, however with climate change the C balance in some areas is shifting towards becoming a C source. Herbivory are an important part of many ec

Fragmented Power : The Reception of China's Foreign Policy Strategies in Sri Lanka

This dissertation proposes a theory concerning China’s “Fragmented Power” in its foreign policy pursuits by analyzing the reception of the “Belt and Road” Initiative in Sri Lanka. The initiative has sparked intense debates and counteractions on the global stage and has become synonymous with Xi Jinping’s assertive approach to foreign policy. However, many aspects of the initiative’s goals, impleme

Statistisk analys av blixtdata för Danmark 2002-2010

Åska hör till ett av de farligaste fenomenen som finns i vår atmosfär. Intresset av att observera åska har alltid funnits hos människan. Först på senare tid har man börjat förstå fysiken bakom fenomenet, även om det fortfarande finns många luckor i kunskapen. Sedan 2000 använder Danmarks Meteorologiska Institut blixtlokaliseringssystemet IMAPCT, som bland annat registrerar nedslagspunkt, strömstyrThunderstorms are one of the most dangerous phenomena in our atmosphere. Mankind has always been interested in observing thunderstorms. It is only recently that we have begun to understand the physics behind this phenomenon. However, there are still many gaps in the knowledge. Since 2000, Denmark has been using the lightning locating system IMPACT which registers strike point, average amperage and

"Särskilt utsatt situation" - Rättstillämpning i strid med lagstiftarens syfte?

On July 1st., 2013 the Swedish rape legislation was changed with the introduction of the prerequisite particulary exposed situation that replaced the previous prerequisite helpless state. The motive for this change was, among other things, that the courts had been too restrictive in their adjudication of the prerequisite helpless state. Furthermore, it seemed impossible to investigate and prosecut