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Global, regional, and national burden of gout, 1990-2020, and projections to 2050 : a systematic analysis of the Global Burden of Disease Study 2021

BACKGROUND: Gout is an inflammatory arthritis manifesting as acute episodes of severe joint pain and swelling, which can progress to chronic tophaceous or chronic erosive gout, or both. Here, we present the most up-to-date global, regional, and national estimates for prevalence and years lived with disability (YLDs) due to gout by sex, age, and location from the Global Burden of Diseases, Injuries

Body mass index and risk of over 100 cancer forms and subtypes in 4.1 million individuals in Sweden : the Obesity and Disease Development Sweden (ODDS) pooled cohort study

BACKGROUND: Obesity, assessed by body mass index (BMI), is an established risk factor for 13 cancers. We aimed to identify further potential obesity-related cancers and to quantify their association with BMI relative to that of established obesity-related cancers.METHODS: Using Cox regression models on 4,142,349 individuals in Sweden (mean age 27.1 years at weight measurement), we calculated hazar

Spatial representativeness and uncertainty of eddy covariance carbon flux measurements for upscaling net ecosystem productivity to the grid scale

Eddy covariance (EC) measurements are often used to validate net ecosystem productivity (NEP) estimated from satellite remote sensing data and biogeochemical models. However, EC measurements represent an integrated flux over their footprint area, which usually differs from respective model grids or remote sensing pixels. Quantifying the uncertainties of scale mismatch associated with gridded flux

Investigation of possible approaches for consequential electricity markets in ecoinvent

Version 3 av ecoinvent är den första databasen att erbjuda möjligheten att koppla samman livscykelinventeringar (LCI) utefter olika länkningsalgoritmer. Genom dessa länkningsalgoritmer tar ecoinvent nu fram bakgrundslivscykelinventeringar med både medeldata och långsiktig marginaldata (t.ex. över elmarknader i olika länder). Idealt sett representerar långsiktig marginaldata över elmarknader den ytVersion 3 of the ecoinvent database is the first background database to offer the possibility to link life cycle inventories (LCI) according to different linking algorithms. Using those algorithms, ecoinvent now provides both average and long-term, marginal background LCI data, (e.g. for electricity markets for different countries). Long-term, marginal data for electricity markets ideally represen

Genetic variability and cadmium metabolism and toxicity

Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING PÅ SVENSKA Kadmium är en giftig metall vilken finns i mat som vi rekommenderas äta mycket av, exempelvis sädesprodukter, grönsaker och skaldjur. Våra matjordar är kontaminerade med kadmium och föroreningen kommer att kvarstå under mycket lång tid framöver. Kadmium skadar framförallt njurarna och skelettet och kan antagligen även orsaAbstract: Cadmium (Cd) is ubiquitous in the environment. Human exposure in non-smokers occurs mainly via intake of healthy food like vegetables, cereals, and shellfish. Adverse health effects on kidney and bone at low-level environmental Cd exposure are well-documented in adults. There is considerable inter-individual variation in both metabolism (toxicokinetics) and toxicity (toxicodynamics) of C

Synchronizing ice-core and U/Th timescales in the Last Glacial Maximum using Hulu Cave 14C and new 10Be measurements from Greenland and Antarctica

Between 15 and 27kyrb2k (thousands of years before 2000CE) during the last glacial, Greenland experienced a prolonged cold stadial phase, interrupted by two short-lived warm interstadials. Greenland ice-core calcium data show two periods, preceding the interstadials, of anomalously high atmospheric dust loading, the origin of which is not well understood. At approximately the same time as the Gree

Priority Health Conditions and Global Life Expectancy Disparities

IMPORTANCE: Life expectancy is a composite health measure reflecting acute and life-course exposures. Identifying conditions behind disparities in life expectancy can guide policy, planning, and financing to battle the most urgent health problems.OBJECTIVE: To examine the contribution of 33 causes of death to life expectancy disparities, highlighting 2 sets of priority conditions-8 infectious and

Drug therapy versus placebo or usual care for comatose survivors of cardiac arrest; a systematic review with meta-analysis

Background: In Europe, approximately 291,000 cardiac arrests occur annually. Despite critical care therapy, hospital mortality remains high. This systematic review assessed whether, in comatose survivors of cardiac arrest, any drug therapy, compared to placebo or usual care, improves outcomes. Methods: We searched Medline, EMBASE, the Cochrane Central Register of Controlled Trials, and The Interna

Uncertainty Modelling in Hydrological Applications - Error Propagation Properties of Random Linear Systems

In hydrological models for water resources management and planning, the model output or design quantities are functions of the input data and a number of parameters that are essentially stochastic processes or random variables. The task of uncertainty analysis is to estimate the uncertainty characteristics of the model output in terms of the uncertainties in the input, model parameters and initial

Get consumers walk into the sustainability talk : an analysis of consumers' sustainability perception via business’s sustainable practice, focusing on a case study from IKEA

As more and more companies are realizing the importance to integrate sustainability with their economic prosperity development, Triple Bottom Line functions as companies' Polaris to guide them to incorporate "People, Planet" considerations into their "Profit" seeking goal. Corporate social responsibility initiatives are adopted by many companies. Among them, Cause Related M

The role of genetic variation and DNA methylation in human glucose metabolism and type 2 diabetes

Popular Abstract in Swedish Diabetes är en grupp sjukdomar som alla kännetecknas av en förhöjd nivå av sockerarten glukos i blodet. Antalet individer som drabbas av diabetes ökar hela tiden, en utveckling som ses över hela världen. Bara i Sverige har drygt 5% av befolkningen diagnosen diabetes, motsvarande 484.400 personer i åldern 20-79 år. Typ 2 diabetes är den vanligaste formen av diabetes, ochThe incidence of diabetes is increasing worldwide, with the most prevalent form being type 2 diabetes. Two fundamental processes contribute to the development of type 2 diabetes: insulin resistance in target organs and insufficient insulin secretion from the pancreatic beta-cells. The aim of this thesis was to explore the role of DNA methylation and common genetic variation on glucose metabolism a

Carbonate Ions and Gastric Cancer

Popular Abstract in Swedish Nästan en miljon nya fall av magsäckscancer diagnostiseras årligen världen över. Även om frekvensen har fallit dramatiskt de senaste åren så är magsäckscancern fortfarande den näst vanligaste orsaken till död i cancer sett ur ett världsperspektiv. Den geografiska variationen av denna cancertyp är anmärkningsvärd med den högsta förekomsten i asiatiska länder såsom Japan,

MKB i svenska CDM projekt

Ett för miljörätten tidigt uppkommet styrmedel som idag hyllas är miljökonsekvensbeskrivningen. Flertalet länder har infört MKB i sin lagstiftning och det har utformats internationella bestämmelser för gränsöverskridande miljöpåverkan. Även inom klimatregimen finns reglering för projekt i CDM systemet. I detta arbete har Sveriges CDM projekt studerats för att fastställa syfte med MKB inom CDM systA respected and early invention among the means of control in environmental law is the impact assessment. Numerous countries have implemented EIA in their national legislation and international treaties regulates transboundary environmental impacts. UNFCCC also contains EIA regulations for projects within the clean development mechanism. In this study Swedish projects are examined to establish the

Precambrian mafic dyke swarms in the Singhbhum craton (eastern India) and their links with dyke swarms of the eastern Dharwar craton (southern India)

Based on trend, cross-cutting relationships and U-Pb dating, Precambrian mafic dykes in the Singhbhum craton, earlier collectively identified as ‘Newer Dolerite Swarm’ have been separated into seven distinct swarms, which are thought to be the plumbing systems for Large Igneous Provinces (LIPs). These Singhbhum swarms range in age from ∼2.80 Ga to ∼1.76 Ga, and include the ∼2.80 Ga NE-SW trending

Aesthetics of Resistance : An investigation into the performative politics of contemporary activism – as seen in 5 events in Scandinavia and beyond

This Ph.D. submission deals with contemporary demonstration culture and political activism, seen as performance through performance. It consists of both a practical and a theoretical part. These are intertwined on various levels of the project. My submission, however, is made up of the two following parts: 1: A textual part, divided into 8 parts. Each part contains a script, an analysis and a nu