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Carbonate Ions and Gastric Cancer

Popular Abstract in Swedish Nästan en miljon nya fall av magsäckscancer diagnostiseras årligen världen över. Även om frekvensen har fallit dramatiskt de senaste åren så är magsäckscancern fortfarande den näst vanligaste orsaken till död i cancer sett ur ett världsperspektiv. Den geografiska variationen av denna cancertyp är anmärkningsvärd med den högsta förekomsten i asiatiska länder såsom Japan,

Uncertainty Modelling in Hydrological Applications - Error Propagation Properties of Random Linear Systems

In hydrological models for water resources management and planning, the model output or design quantities are functions of the input data and a number of parameters that are essentially stochastic processes or random variables. The task of uncertainty analysis is to estimate the uncertainty characteristics of the model output in terms of the uncertainties in the input, model parameters and initial

Pharmacological characterization of a novel investigational antimuscarinic drug, fesoterodine, in vitro and in vivo.

OBJECTIVE To investigate the primary pharmacology of fesoterodine (a novel antimuscarinic drug developed for treating overactive bladder) and SPM 7605 (its active metabolite, considered to be the main pharmacologically active principle of fesoterodine in man) against human muscarinic receptor subtypes, and to investigate in vitro and in vivo functional activity of these agents on the rat bladder c

Epidemiology of stroke in an urban population - aspects of time, place and person

Popular Abstract in Swedish Epidemiologi är den vetenskap som studerar sjukdomars förekomst och spridning och hur detta varierar över tiden, mellan geografiska områden och mellan grupper av individer definierade i olika termer. I Malmö finns det mycket goda möjligheter att göra epidemiologiska studier av slaganfall (stroke). Dels finns ett register som följt strokeinsjuknandet sedan 1989. Dels harThe present thesis explored the epidemiology of stroke in Malmö, Sweden, an urban population of approximately 250000 inhabitants. Incidence of stroke in Malmö has been monitored since 1989. The National census investigation in 1990 was used to get information about the background population in the city. Previous studies of the seasonal and weekday variations in incidence of stroke have shown inco

Priority Health Conditions and Global Life Expectancy Disparities

IMPORTANCE: Life expectancy is a composite health measure reflecting acute and life-course exposures. Identifying conditions behind disparities in life expectancy can guide policy, planning, and financing to battle the most urgent health problems.OBJECTIVE: To examine the contribution of 33 causes of death to life expectancy disparities, highlighting 2 sets of priority conditions-8 infectious and

Drug therapy versus placebo or usual care for comatose survivors of cardiac arrest; a systematic review with meta-analysis

Background: In Europe, approximately 291,000 cardiac arrests occur annually. Despite critical care therapy, hospital mortality remains high. This systematic review assessed whether, in comatose survivors of cardiac arrest, any drug therapy, compared to placebo or usual care, improves outcomes. Methods: We searched Medline, EMBASE, the Cochrane Central Register of Controlled Trials, and The Interna

Synchronizing ice-core and U/Th timescales in the Last Glacial Maximum using Hulu Cave 14C and new 10Be measurements from Greenland and Antarctica

Between 15 and 27kyrb2k (thousands of years before 2000CE) during the last glacial, Greenland experienced a prolonged cold stadial phase, interrupted by two short-lived warm interstadials. Greenland ice-core calcium data show two periods, preceding the interstadials, of anomalously high atmospheric dust loading, the origin of which is not well understood. At approximately the same time as the Gree

Genetic variability and cadmium metabolism and toxicity

Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING PÅ SVENSKA Kadmium är en giftig metall vilken finns i mat som vi rekommenderas äta mycket av, exempelvis sädesprodukter, grönsaker och skaldjur. Våra matjordar är kontaminerade med kadmium och föroreningen kommer att kvarstå under mycket lång tid framöver. Kadmium skadar framförallt njurarna och skelettet och kan antagligen även orsaAbstract: Cadmium (Cd) is ubiquitous in the environment. Human exposure in non-smokers occurs mainly via intake of healthy food like vegetables, cereals, and shellfish. Adverse health effects on kidney and bone at low-level environmental Cd exposure are well-documented in adults. There is considerable inter-individual variation in both metabolism (toxicokinetics) and toxicity (toxicodynamics) of C

MKB i svenska CDM projekt

Ett för miljörätten tidigt uppkommet styrmedel som idag hyllas är miljökonsekvensbeskrivningen. Flertalet länder har infört MKB i sin lagstiftning och det har utformats internationella bestämmelser för gränsöverskridande miljöpåverkan. Även inom klimatregimen finns reglering för projekt i CDM systemet. I detta arbete har Sveriges CDM projekt studerats för att fastställa syfte med MKB inom CDM systA respected and early invention among the means of control in environmental law is the impact assessment. Numerous countries have implemented EIA in their national legislation and international treaties regulates transboundary environmental impacts. UNFCCC also contains EIA regulations for projects within the clean development mechanism. In this study Swedish projects are examined to establish the

Precambrian mafic dyke swarms in the Singhbhum craton (eastern India) and their links with dyke swarms of the eastern Dharwar craton (southern India)

Based on trend, cross-cutting relationships and U-Pb dating, Precambrian mafic dykes in the Singhbhum craton, earlier collectively identified as ‘Newer Dolerite Swarm’ have been separated into seven distinct swarms, which are thought to be the plumbing systems for Large Igneous Provinces (LIPs). These Singhbhum swarms range in age from ∼2.80 Ga to ∼1.76 Ga, and include the ∼2.80 Ga NE-SW trending

Re-positive Cases of Nucleic Acid Tests in Discharged Patients With COVID-19 : A Follow-Up Study

Background: The frequent emergence of the re-positive patients with COVID-19 is a potential threat worldwide. This study aimed to describe data from admission to follow-up for patients with COVID-19 and analyze the possible causes for re-positive nucleic acid tests to provide more scientific basis for reducing the numbers of re-positive patients after discharge. Methods: We retrospectively recorde

Comparison of Different Methods for Spatial Downscaling of GPM IMERG V06B Satellite Precipitation Product Over a Typical Arid to Semi-Arid Area

Spatial downscaling is an effective way to obtain precipitation with sufficient spatial details. The performance of downscaling is typically determined by the empirical statistical relationships between precipitation and the used auxiliary variables. In this study, we conducted a comprehensive comparison of five empirical statistical methods for spatial downscaling of GPM IMERG V06B monthly and an

Investigation of possible approaches for consequential electricity markets in ecoinvent

Version 3 av ecoinvent är den första databasen att erbjuda möjligheten att koppla samman livscykelinventeringar (LCI) utefter olika länkningsalgoritmer. Genom dessa länkningsalgoritmer tar ecoinvent nu fram bakgrundslivscykelinventeringar med både medeldata och långsiktig marginaldata (t.ex. över elmarknader i olika länder). Idealt sett representerar långsiktig marginaldata över elmarknader den ytVersion 3 of the ecoinvent database is the first background database to offer the possibility to link life cycle inventories (LCI) according to different linking algorithms. Using those algorithms, ecoinvent now provides both average and long-term, marginal background LCI data, (e.g. for electricity markets for different countries). Long-term, marginal data for electricity markets ideally represen

Spatial representativeness and uncertainty of eddy covariance carbon flux measurements for upscaling net ecosystem productivity to the grid scale

Eddy covariance (EC) measurements are often used to validate net ecosystem productivity (NEP) estimated from satellite remote sensing data and biogeochemical models. However, EC measurements represent an integrated flux over their footprint area, which usually differs from respective model grids or remote sensing pixels. Quantifying the uncertainties of scale mismatch associated with gridded flux

Global Disparities in Premature Mortality

Importance: Persistent disparities in mortality across countries suggest uneven improvements in living standards and access to life-extending health technologies, as well as context-specific obstacles. Studies have analyzed cross-country inequality in mortality but have not widely contextualized those disparities in terms of developmental progress relative to a frontier representing a level of mor

Interplay between astrocyte reactivity and APOE ε4 status is associated with accelerated pTau-related tau pathology in Alzheimer’s disease

Background: Various plasma phosphorylated tau species have been shown to be associated with amyloid-β (Aβ) PET and Tau PET in Alzheimer’s disease (AD), but whether APOE ε4 affects the interaction between glial fibrillary acidic protein (GFAP) and phosphorylated tau (pTau), and whether a three-way interaction exists among APOE ε4, GFAP, and pTau that influences AD progression remain unclear. Method

På AI-teknikens axlar : Om kunskapssociologin och stark artificiell intelligens

Popular Abstract in Swedish Avhandlingen diskuterar Sociologins position i debatten kring artificiell intelligens, d.v.s sådan AI som kan skapa kunskap på egen hand. Det påpekas att sociologin behöver göra en åtskillnad mellan två sätt att skapa AI system: Symbolisk AI (eller Klassisk AI) och Distribuerad AI – DAI. Den sociologiska litteraturen visar en i stort kritisk attityd till symbolisk AI viThis dissertation is concerned with Sociology’s stance in the debate on Strong Artificial Intelligence, i.e. such AI that is able to shape new knowledge without human interference. There is a need for sociologists to realize the difference between two approaches to constructing AI systems: Symbolic AI (or Classic AI) and Distributed AI – DAI. Sociological literature shows a largely critical attitu

Fish Lenses : Anatomy and Optics

How fish eyes may save yours?According to the World Health Organization, cataract was responsible for over half of the blindness world-wide in 2010. Getting a cataract means that the lens inside your eye gets clouded, preventing clear, sharp vision. Cataract can be caused by age, physical trauma, genetics, or even skin disease. It can virtually happen to everyone. It is possible to fix cataract byI have investigated some of the biological regulatory mechanisms governing the development of crystalline lenses. I used fish as model animals because they possess optically interesting lenses, while the geometrical simplicity of fish lenses allows for studies that are difficult or impossible with the lenses of other animals.First we have investigated lens optical plasticity by measuring longitudi