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Gangliosides are sialic acid-containing glycosphingolipids that often are present in increased amounts on tumor cells. Since the gangliosides are hydroxy-acids, they can form lactones. The lactones have been suspected to be more immunogenic than the open forms, but are in practise poor immunogens due to their ease of hydrolysis. This thesis describes the synthesis of the hydrolytically stable lact
I en globaliserad värld står ICC inför svåra utmaningar i fullgörandet av sitt uppdrag att inte lämna de allvarligaste av brott, som angår det internationella samfundet, ostraffade. Stater som inte är parter i Romstadgan har uttalat att domstolen kränker deras statssuveränitet. Särskilt ICC:s agerande gällande deportationen av uigurer till Xinjiang och deportationen av rohingyer från Myanmar till
Objective Second language learning continues to be a field of growing interest both in academia and everyday life. As such, a more comprehensive understanding of the best learning methods remains an important area of focus. This study aimed to investigate single-session vocabulary acquisition and neural underpinnings of language learning through Diffusion Tensor Imaging (DTI), in relation to immer
Breast cancer incidence has markedly increased in Western countries for reasons that are not entirely understood. We characterized periodic and age-specific incidence trends of breast cancer in immigrants who migrated from low incidence areas to Sweden. The incidence in immigrants was compared to that in native Swedes and standardized incidence ratios (SIRs) were calculated, based on the Swedish F
This paper investigates the determinants of Climbing World Cup performance at a country level. An unbalanced panel of 76 countries over the years 2005 through 2008 is used. The focus of the paper is on the impact of the demographic, economic, geographic and historic predictors of the success at the Climbing World Cups. We measure the performance by the National Team rankings for each of the three
Core elements of countries’ clean energy industry success, as well as low-carbon economic development, have attracted various levels of interest from countries around the world. This thesis is based on an analysis of the EU Critical Raw Materials Act. With regard, it gives the background of what the regulation is about and its rationale. In a critical way, it has analyzed some elements of the chal
LEVTEK SWEDEN AB håller på att lansera en ny typ av elektriskt drivet fordon vid namn LEVKARTEN. Produkten ska med sina fyra hjul vara lätt och stabil att köra samtidigt som den erbjuder goda lastmöjligheter både inomhus och utomhus. Fordonet är utrustat med avancerade funktioner som möjliggör ökad säkerhet samt semi-autonom eller autonom körning. Innan Levtek lanserar deras nya produkt, vill de uThe start-up company LEVTEK is launching a new ultralight electric utility vehicle called the LEVKART. The Levkart uses a combination of robotics and AI-technology to offer semi-autonomous or autonomous riding and usage. The purpose of the vehicle is to serve as an alternative to cargo bikes and electric scooters designed for easy usage and as a more sustainable option to fossil-based transport. T
This thesis examines the interplay between gender and the perception of impoliteness in the Japanese workplace. Firstly, impoliteness is an area in sociolinguistics that discusses face-threatening acts, perceived in situations modified by different aspects, e.g. context and the gender of the interlocutors. Secondly, gendered language is another area within sociolinguistics which gained popularity
With the rapid advancement of urban renewal and the shift toward sustainable development, the integration of Transit-Oriented Development (TOD) and industrial heritage preservation has become a key strategy in revitalizing post-industrial cities. Rather than viewing industrial heritage sites as obsolete, new approaches now emphasize their adaptive reuse within the framework of transit-accessible,
Introduction: Emergency departments (ED) globally are addressing the coronavirus disease 2019 (COVID-19) pandemic with varying degrees of success. We leveraged the 17-country, Emergency Medicine Education & Research by Global Experts (EMERGE) network and non-EMERGE ED contacts to understand ED emergency preparedness and practices globally when combating the COVID-19 pandemic. Methods: We elect
Precipitation data at high spatio-temporal resolution are essential for hydrological, meteorological, and ecological research in local basins and regions. The coarse spatial resolution (0.25°) of Tropical Rainfall Measuring Mission (TRMM) 3B43 product is insufficient for practical requirements. In this paper, a multivariable geographically weighted regression (GWR) downscaling method was developed
Incidence of differentiated thyroid carcinoma (DTC) varies considerably between ethnic groups, with particularly high incidence rates in Pacific Islanders. DTC is one of the cancers with the highest familial risk suggesting a major role of genetic risk factors, but only few susceptibility loci were identified so far. In order to assess the contribution of known DTC susceptibility loci and to ident
The COVID-19 pandemic has wreaked havoc in every country in the world, with serious health-related, economic, and social consequences. Since its outbreak in March 2020, many researchers from different fields have joined forces to provide a wide range of solutions, and the support for this work from artificial intelligence (AI) and other emerging concepts linked to intelligent data analysis has bee
Both atmospheric nitrogen (N) deposition and precipitation can strongly impact below-ground biogeochemical processes. Soil extracellular enzymes activities (EEAs) and microorganisms are considered as the key agents in ecosystem nutrient cycling. However, how the interaction between increasing N deposition and precipitation may affect soil EEAs and microbes remain poorly understood. In a 5-year fie
Identifying where and when population ‘bottlenecks’ occur is critical to the conservation of migratory species, many of which are declining precipitously worldwide. Especially challenging is the evaluation of changes to staging sites. These sites are indispensable links in the migratory cycle but are typically used only briefly. We devised a field-based approach to assess the quality and carrying
