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The progressive accumulation, aggregation, and spread of α-synuclein (αSN) are common hallmarks of Parkinson’s disease (PD) pathology. Moreover, numerous proteins interact with αSN species, influencing its toxicity in the brain. In the present study, we extended analyses of αSN-interacting proteins to cerebrospinal fluid (CSF). Using coimmunoprecipitation, followed by mass spectrometry, we found t
A thermodynamic property model for the non-aqueous precipitating CO2 capture system 2-amino-2-methyl-1-propanol (AMP) in N-methyl-2-pyrrolidone (NMP) has been developed. The binary NRTL interaction parameters, electrolyte pair parameters, and equilibrium constant for the precipitation reaction were estimated from experimental data using the unsymmetrical electrolyte NRTL property method (ENRTL-RK)
Microorganisms in soil are commonly limited by available substrate, and removing the limitation will increase activity and growth, with predictable dynamics in growth. The initial phase with a lag period (λ) will usually be followed by exponential growth (also called log phase, with growth rate μ). These two growth phases may be differently affected by environmental conditions, like temperature an
Rivers have traditionally been viewed as negligible sources of iron (Fe) to marine waters, as most Fe gets lost during estuarine mixing. However, recent findings demonstrate that Fe from boreal rivers display a higher resistance towards salinity-induced aggregation, presumably due to stabilizing interactions with organic matter. Previous studies have shown that Fe (oxy)hydroxides are selectively r
On-line teaching situations where a tutor and their students are remote from each other mean that contact between them is reduced compared with teaching in a classroom. We report an initial study of two-way gaze sharing between a tutor and a group of students, who were in different locations. A 45-min class consisted of an introductory lecture followed by an exercise in using two software tools, o
OBJECTIVE: To determine the time required for a preclinical Alzheimer disease population to decline in a meaningful way, use estimates of decline to update previous clinical trial design assumptions, and identify factors that modify β-amyloid (Aβ)-related decline. METHODS: In 1,120 cognitively unimpaired individuals from 3 international cohorts, we estimated the relationship between Aβ status and
High-spin states in the Br73 nucleus have been populated via the Cr50(Si28,αp)Br73 fusion evaporation reaction with a beam energy of 90 MeV. The deexciting gamma rays were detected using the Indian National Gamma Array (INGA). Using the γ-γ coincidence technique, two new bands and eight new interconnecting transitions have been added. The strong interconnecting E1 transitions, between positive and
BACKGROUND: The dual-mobility acetabular cup (DMC) has an additional bearing consisting of a mobile polyethylene component between the prosthetic head and the outer metal shell. This design has gained popularity in revision total hip arthroplasty (THA) and in primary treatment of femoral neck fractures with the anticipation of a reduced risk of THA instability. Our primary aim was to evaluate the
Cryptochromes are blue-light photoreceptor proteins, which provide input to circadian clocks. The cryptochrome from Drosophila melanogaster (DmCry) modulates the degradation of Timeless and itself. It is unclear how light absorption by the chromophore and the subsequent redox reactions trigger these events. Here, we use nano- to millisecond time-resolved x-ray solution scattering to reveal the lig
Background: Pediatric anxiety disorders are highly prevalent and associated with significant functional disabilities and lifelong morbidity. Cognitive-behavioral therapy (CBT), sertraline, and their combination are effective treatments, but little is known about how these treatments exert their effects.Methods: Using network intervention analysis (NIA), we analyzed data from the largest randomized
Developing a place into ‘a good place to live’ for people of all ages is a prioritized issue in many municipalities in Sweden, as well as around the world. But what do we really mean by ‘a good place to live’? How do the residents themselves comprehend and perceive ‘a good place to live’? And how do municipalities view their place and what they offer to their residents? This thesis explores how ‘a
Since 2007, rural areas, particularly across the global south, have been ravaged by what has been dubbed a “global resource rush”. On the heels of this rush, a new wave of dispossession studies across the fields of agrarian political economy, human geography and political ecology is emerging. A decade into this wave, a series of conceptual challenges in the literature are identifiable, namely 1) t
The spatial distribution of organic soil nitrogen (N) in alpine tundra was studied along a natural environmental gradient, covering five plant communities, at the Latnjajaure Field Station, northern Swedish Lapland. The five communities (mesic meadow, meadow snowbed, dry heath, mesic heath, and heath snowbed) are the dominant types in this region and are differentiated by soil pH. Net N mineraliza
